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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 5
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Original Article

Effects of chemical and enzymic probes on microsomal covalent binding of bromobenzene and derivatives. Evidence for quinones as reactive metabolites

John A. Buben Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, 6045-2500, USA
,
N. Narasimhan Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, 6045-2500, USA
&
Robert P. Hanzlik Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, 6045-2500, USA
Pages 501-510 | Received 12 May 1987, Accepted 13 Dec 1987, Published online: 30 Sep 2009

Citations (16)

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Read on this site (2)

Nicholas E. Weber. (1990) Overview of Bound Residue Chemistry. Drug Metabolism Reviews 22:6-8, pages 611-615.
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Rune Becher, Jon E. Dahl, Kjell Aarstad, Odd C. Nilsen & Erik Dybing. (1989) Lung and Liver Damage in Mice After Bromobenzene Inhalation: Effects of Enzyme Inducers. Inhalation Toxicology 1:2, pages 181-196.
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Articles from other publishers (14)

Mi-Jin Yim, Grace Choi, Jeong Min Lee, Soon-Yeong Cho & Dae-Sung Lee. (2017) Protective effects of alginate-free residue of sea tangle against hyperlipidemic and oxidant activities in rats. Fisheries and Aquatic Sciences 20:1.
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Albert R. Vaughn, Caitlin B. Redman, Sophia M. Kang & Jisook Kim. (2013) Biological implications of 2-chlorocyclohexa-2,5-diene-1,4-dione toward ribonuclease A. Advances in Bioscience and Biotechnology 04:01, pages 22-28.
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Jong Cheol Park, Won Dong Han, Jeong Ro Park, Seong Hee Choi & Jong Won Choi. (2005) Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. Journal of Ethnopharmacology 102:3, pages 313-318.
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Bo Han Wang, Katherine A. Zuzel, Khalid Rahman & David Billington. (1999) Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices. Toxicology 132:2-3, pages 215-225.
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Bo Han Wang, Katherine A Zuzel, Khalid Rahman & David Billington. (1998) Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices. Toxicology 126:3, pages 213-222.
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P. Souček, B. Filipcova & I. Gut. (1994) Cytochrome P450 destruction and radical scavenging by benzene and its metabolites. Biochemical Pharmacology 47:12, pages 2233-2242.
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Cathaline den Besten, Marlies Ellenbroek, Marjan A.E. van der Ree, Ivonne M.C.M. Rietjens & Peter J. van Bladeren. (1992) The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes. Chemico-Biological Interactions 84:3, pages 259-275.
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Cherukury Madhu & Curtis D. Klaassen. (1992) Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats. Toxicology Letters 60:2, pages 227-236.
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Cathaline den Besten, Marjan C.C. Smink, Erik J. de Vries & Peter J. van Bladeren. (1991) Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: A major role for quinone metabolites. Toxicology and Applied Pharmacology 108:2, pages 223-233.
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W.C. Mennes, C.W.M. van Holsteijn, J. Noordhoek & B.J. Blaauboer. (1991) Comparative cytotoxicity of bromobenzene in primary cultures of rat and hamster hepatocytes and its relation to biotransformation. Toxicology in Vitro 5:1, pages 63-70.
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Catarina Eriksson & Eva B. Brittebo. (1991) Metabolic activation of the herbicide dichlobenil in the olfactory mucosa of mice and rats. Chemico-Biological Interactions 79:2, pages 165-177.
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Eva B. Brittebo, Catarina Eriksson & Ingvar Brandt. (1990) Activation and toxicity of bromobenzene in nasal tissues in mice. Archives of Toxicology 64:1, pages 54-60.
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C. den Besten, M.M.C.G. Peters & P.J. van Bladeren. (1989) The metabolism of pentachlorobenzene by rat liver microsomes: The nature of the reactive intermediates formed. Biochemical and Biophysical Research Communications 163:3, pages 1275-1281.
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Michael Buonarati, Dexter Morin, Charles Plopper & Alan Buckpitt. (1989) Glutathione depletion and cytotoxicity by naphthalene 1,2-oxide in isolated hepatocytes. Chemico-Biological Interactions 71:2-3, pages 147-165.
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