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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 5
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Original Article

The pharmacokinetics and metabolism of idazoxan in the rat

C. J. Lewis Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
,
M. E. Havler Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
,
M. J. Humphrey Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
,
J. G. Lloyd-Jones Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
,
M. A. McCleavy Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
,
N. C. Muir Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
&
K. Waltham Department of Biochemistry, Pharmaceutical Division, Reckitt and Colman, Dansom Lane, Hull, HU8 7DS
 show all
Pages 519-532 | Received 27 May 1987, Accepted 18 Dec 1987, Published online: 30 Sep 2009

Citations (11)

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W. R. Rush, D. J. Hall, D. J. M. Graham & I. A. Selby. (1992) The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica 22:2, pages 237-246.
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Articles from other publishers (10)

Philippe Becquet, Mercedes Vazquez-Anon, Yves Mercier, Karen Wedekind, Tahir Mahmood, Dolores I. Batonon-Alavo & Frances Yan. (2023) A systematic review of metabolism of methionine sources in animals: One parameter does not convey a comprehensive story. Animal Nutrition 13, pages 31-49.
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Philippe Becquet, Mercedes Vazquez-Anon, Yves Mercier, Dolores I. Batonon-Alavo, Frances Yan, Karen Wedekind & Tahir Mahmood. (2023) Absorption of methionine sources in animals—is there more to know?. Animal Nutrition 12, pages 159-170.
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Louise K. Refsgaard, Kia Haubro, Darryl S. Pickering, Sarah A. Stuart, Emma S. J. Robinson & Jesper T. Andreasen. (2016) Effects of sertraline, duloxetine, vortioxetine, and idazoxan in the rat affective bias test. Psychopharmacology 233:21-22, pages 3763-3770.
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Joaquim Valles, Rossend Obach, Angel Menargues, Joan Pruñonosa & Francesc Jane. (1995) A Pharmacokinetic-pharmacodynamic Linking Model for the α2-Adrenergic Antagonism of Idazoxan on Clonidine-induced Mydriasis in the Rat. Journal of Pharmacy and Pharmacology 47:2, pages 157-161.
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J Vallès, J Pruñonosa, A Menargues, M Nomen & R Obach. (1989) Pharmacokinetic Profile of Idazoxan in the Beagle Dog. Journal of Pharmacy and Pharmacology 41:6, pages 384-387.
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Christopher L. Shaffer, Mithat Gunduz, Bruce A. Thornburgh & Gwendolyn D. Fate. (2006) Using a Tritiated Compound to Elucidate Its Preclinical Metabolic and Excretory Pathways in Vivo: Exploring Tritium Exchange Risk. Drug Metabolism and Disposition 34:9, pages 1615-1623.
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Susan H. Fox, Brian Henry, Micheal P. Hill, David Peggs, Alan R. Crossman & Jonathan M. Brotchie. (2001) Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: Evidence from the effects of the alpha2 adrenoceptor antagonist idazoxan. Movement Disorders 16:4, pages 642-650.
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. 2001. Metabolic Maps. Metabolic Maps 288 295 .
Daniel Antier, Florence Franconi & Frédéric Sannajust. (1999) Idazoxan does not prevent but worsens focal hypoxic-ischemic brain damage in neonatal Wistar rats. Journal of Neuroscience Research 58:5, pages 690-696.
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Helen C. Jackson, I.J. Griffin & D.J. Nutt. (2012) The effects of idazoxan and other α 2 ‐adrenoceptor antagonists on food and water intake in the rat . British Journal of Pharmacology 104:1, pages 258-262.
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