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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 5
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Original Article

The influence of diaziquone free radicals on the in vitro activity of diaziquone

Binh Nguyen University of Maryland Cancer Center, Division of Developmental Therapeutics, 655 West Baltimore Street, Baltimore, Maryland, 21201, USA
,
Sandip Biswal University of Maryland Cancer Center, Division of Developmental Therapeutics, 655 West Baltimore Street, Baltimore, Maryland, 21201, USA
&
Peter L. Gutierrez University of Maryland Cancer Center, Division of Developmental Therapeutics, 655 West Baltimore Street, Baltimore, Maryland, 21201, USA
Pages 593-602 | Received 06 Jul 1987, Accepted 01 Jan 1988, Published online: 30 Sep 2009

Citations (8)

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P.A. Amstad, H. Liu, M. Ichimiya, I.K. Berezesky, B.F. Trump, I.A. Buhimschi & P.L. Gutierrez. (2001) BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production. Redox Report 6:6, pages 351-362.
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Articles from other publishers (7)

R. Mecke, H.H. Jäger & M. Jäger. 2004. Nitrogen and Oxygen Centered Radicals. Nitrogen and Oxygen Centered Radicals 475 480 .
George H. Harrison, Elizabeth K. Balcer-Kubiczek & Peter L. Gutierrez. (1996) In vitro mechanisms of chemopotentiation by tone-burst ultrasound. Ultrasound in Medicine & Biology 22:3, pages 355-362.
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Geoffrey R. Fisher, Joshua Donis & Peter L. Gutierrez. (1992) Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. Biochemical Pharmacology 44:8, pages 1625-1635.
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Geoffrey R. Fisher & Peter L. Gutierrez. (1991) Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase. Free Radical Biology and Medicine 11:6, pages 597-607.
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James H. Doroshow, Steven Akman, Fong-Fong Chu & Steven Esworthy. (1990) Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones. Pharmacology & Therapeutics 47:3, pages 359-370.
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Klaas J. Lusthof, Nicolaas J. De Mol, Lambert H.M. Janssen, Richard J.M. Egberink, Willem Verboom & David N. Reinhoudt. (1990) Covalent binding studies on the 14C-labeled antitumour compound 2,5-bis(1-aziridinyl)-1,4-benzoquinone. Involvement of semiquinone radical in binding to DNA, and binding to proteins and bacterial macromolecules in situ. Chemico-Biological Interactions 76:2, pages 193-209.
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Peter L. Gutierrez. (1989) Mechanism(s) of bioreductive activation. Free Radical Biology and Medicine 6:4, pages 405-445.
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