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Xenobiotica

the fate of foreign compounds in biological systems

Volume 18, 1988 - Issue 6

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Original Article

The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes

V. Rogiers Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium

Y. Vandenberghe Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium

A. Callaerts Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium

W. Sonck Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium

V. Maes Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium; Department of Clinical Chemistry, Free University Brussels, Laarbeeklaan 103, B-1090, Brussels, Belgium

A. Vercruysse Department of Toxicology, Laarbeeklaan 103, B-1090, Brussels, Belgium

Pages 665-673 | Published online: 30 Sep 2009

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https://doi.org/10.3109/00498258809041705

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Şule Seçkin, Canan Başaran-Küçükgergin & Müjdat Uysal. (1999) Effect of Acute and Chronic Administration of Sodium Valproate on Lipid Peroxidation and Antioxidant System in Rat Liver. Pharmacology & Toxicology 85, pages 294-298.
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Georges de Sousa, Florence Nicolas, Michel Placidi, Roger Rahmani, Marc Benicourt, Bernard Vannier, Giocondo Lorenzon, Karine Mertens, Sandra Coecke, Andre Callaerts, Vera Rogiers, Shamas Khan, Phil Roberts, Paul Skett, Alain Fautrel, Christophe Chesne & Andre Guillouzo. (1999) A multi-laboratory evaluation of cryopreserved monkey hepatocyte functions for use in pharmaco–toxicology. Chemico-Biological Interactions 121:1, pages 77-97.
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Vera Rogiers, May Akrawi, Antoine Vercruysse, Ian R. Phillips & Elizabeth A. Shephard. (1995) Effects of the Anticonvulsant, Valproate, on the Expression of Components of the Cytochrome-P-450-Mediated Monooxygenase System and Glutathione S-Transferases. European Journal of Biochemistry 231:2, pages 337-343.
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Vera Rogiers, May Akrawi, Antoine Vercruysse, Ian R. Phillips & Elizabeth A. Shephard. (2008) Effects of the Anticonvulsant, Valproate, on the Expression of Components of the Cytochrome‐ P ‐450‐Mediated Monooxygenase System and Glutathione S ‐Transferases . European Journal of Biochemistry 231:2, pages 337-343.
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V. Rogiers & A. Vercruysse. (1993) Rat hepatocyte cultures and co-cultures in biotransformation studies of xenobiotics. Toxicology 82:1-3, pages 193-208.
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Hsiu‐Ying Yu, Mei‐Sue Wu & Yu‐Zen Shen. (2006) Nonlinear elimination and hepatic concentration of conjugation‐ metabolite of valproate in guinea‐pigs. Biopharmaceutics & Drug Disposition 14:4, pages 297-312.
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Gail D. Anderson, Andrew A. Acheampong, Alan J. Wilensky & René H. Levy. (2005) Effect of Valproate Dose on Formation of Hepatotoxic Metabolites. Epilepsia 33:4, pages 736-742.
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V. Rogiers, A. Callaerts, A. Vercruysse, M. Akrawi, E. Shephard & I. Phillips. (1992) Effects of valproate on xenobiotic biotransformation in rat liver. Pharmaceutisch Weekblad Scientific Edition 14:3, pages 127-131.
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V. Rogiers, M. Akrawi, Y. Vandenberghe, E. Shephard, I. Phillips & A. Vercruysse. 1992. Medical Toxicology. Medical Toxicology 156 159 .

J. Edward Fisher, Heinz Nau & Wolfgang Löscher. (2007) Alterations in the Renal Excretion of Valproate and Its Metabolites After Chronic Treatment. Epilepsia 32:1, pages 146-150.
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Vera Rogiers, Yves Vandenberghe, André Callaerts, Gino Verleye, Miranda Cornet, Karine Mertens, Walter Sonck & Antoine Vercruysse. (1990) Phase I and phase II xenobiotic biotransformation in cultures and co-cultures of adult rat hepatocytes. Biochemical Pharmacology 40:8, pages 1701-1706.
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A. Viani, A. Temellini, G. Tusini & G.M. Pacifici. (2016) Human Brain Sulphotransferase and Glucuronyltransferase. Human & Experimental Toxicology 9:2, pages 65-69.
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V. Rogiers, Y. Vandenberghe, A. Callaerts, W. Sonck & A. Vercruysse. (1990) Effects of dimethylsulphoxide on phase I and II biotransformation in cultured rat hepatocytes. Toxicology in Vitro 4:4-5, pages 439-442.
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The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes

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The inducing and inhibiting effects of sodium valproate in vivo on the biotransformation systems of xenobiotics in isolated rat hepatocytes

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