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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen

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Pages 737-745 | Published online: 30 Sep 2009

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Read on this site (3)

Urs A. Boelsterli, Hyman J. Zimmerman & Anke Kretz-Rommel. (1995) Idiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and Pathology. Critical Reviews in Toxicology 25:3, pages 207-235.
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R. Jover, X. Ponsoda, M. J. Gómez-lechón & J. V. Castell. (1992) Potentiation of heroin and methadone hepatotoxicity by ethanol: an in vitro study using cultured human hepatocytes. Xenobiotica 22:4, pages 471-478.
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Steven A. Hamburger & Paul B. McCay. (1990) Spin Trapping of Ibuprofen Radicals: Evidence That Ibuprofen is a Hydroxyl Radical Scavenger. Free Radical Research Communications 9:3-6, pages 337-342.
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Articles from other publishers (21)

Conor Young & William Eggleston. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 443 447 .
Emanuela Ferretti, Eric Tremblay, Marie-Pierre Thibault, Sepideh Fallah, David Grynspan, Karolina M. Burghardt, Marcos Bettolli, Corentin Babakissa, Emile Levy & Jean-François Beaulieu. (2018) Impaired antimicrobial response and mucosal protection induced by ibuprofen in the immature human intestine. Pediatric Research 84:6, pages 813-820.
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K.D. Rainsford. 2015. Ibuprofen. Ibuprofen 132 236 .
James H. Lewis & Jonathan G. Stine. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 369 401 .
Spomenko Ilic, Domagoj Drmic, Kamelija Zarkovic, Danijela Kolenc, Luka Brcic, Bozo Radic, Viktor Djuzel, Alenka Boban Blagaic, Zeljko Romic, Senka Dzidic, Livije Kalogjera, Sven Seiwerth & Predrag Sikiric. (2011) Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats. European Journal of Pharmacology 667:1-3, pages 322-329.
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Radu M. Nanau & Manuela G. Neuman. (2010) Ibuprofen-induced hypersensitivity syndrome. Translational Research 155:6, pages 275-293.
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. 2010. Drug Safety Evaluation. Drug Safety Evaluation 788 860 .
Shayne Cox Gad. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
María J. Gómez‐Lechón, Teresa Donato, Ramiro Jover, Cristina Rodriguez, Xavier Ponsoda, Denize Glaise, José V. Castell & Christiane Guguen‐Guillouzo. (2002) Expression and induction of a large set of drug‐metabolizing enzymes by the highly differentiated human hepatoma cell line BC2. European Journal of Biochemistry 268:5, pages 1448-1459.
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Maria José Gómez-Lechón, Ramiro Jover, Teresa Donato, Xavier Ponsoda & José V. Castell. 2000. Signaling Through the Cell Matrix. Signaling Through the Cell Matrix 89 104 .
Robert E. Kimura, Sally Ann D. Dy, Michael R. Uhing, David W. A. Beno, Vanida A. Jiyamapa & John D. Lloyd-Still. (1999) The Effects of High-Dose Ibuprofen and Pancreatic Enzymes on the Intestine of the Rat. Journal of Pediatric Gastroenterology and Nutrition 29:2, pages 178-183.
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Mario Gonzalez-de la Parra, Carlos Ramos-Mundo, Manuel Jimenez-Estrada, Claudia Ponce-de Leon, R. Castillo, Veronica Tejeda, Karla G. Cuevas & Raul G. Enriquez. (2020) A Germination Bioassay as a Toxicological Screening System for Studying the Effects of Potential Prodrugs of Naproxen. Alternatives to Laboratory Animals 26:5, pages 635-647.
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JOSÉ V. CASTELL, MARÍA JOSÉ GÓMEZ-LECHÓN, XAVIER PONSODA & ROQUE BORT. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 375 410 .
ALISON E.M. VICKERS. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 103 127 .
M. Jurima-Romet, K. Crawford & H.S. Huang. (1994) Comparative cytotoxicity of non-steroidal anti-inflammatory drugs in primary cultures of rat hepatocytes. Toxicology in Vitro 8:1, pages 55-66.
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Kathleen M. Knights & Roger Drew. (1992) The effects of ibuprofen enantiomers on hepatocyte intermediary metabolism and mitochondrial respiration. Biochemical Pharmacology 44:7, pages 1291-1296.
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M.T. Donato, F. Goethals, M.J. Gómez-Lechón, D. Deboyser, I. De Coster, M. Roberfroid & J.V. Castell. (1992) Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicology in Vitro 6:4, pages 295-302.
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X. Ponsoda, R. Jover, J.V. Castell & M.J. Gómez-Lechón. (1992) Potentiation of cocaine hepatotoxicity in human hepatocytes by ethanol. Toxicology in Vitro 6:2, pages 155-158.
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Ramiro Jover, Xavier Ponsoda, M.José Gómez-Lechón, Conrado Herrero, Javier Del Pino & JoséV. Castell. (1991) Potentiation of cocaine hepatotoxicity by ethanol in human hepatocytes. Toxicology and Applied Pharmacology 107:3, pages 526-534.
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X. Ponsoda, R. Jover, M.J. Gómez-Lechón, R. Fabra, R. Trullenque & J.V. Castell. (1991) The effects of buprenorphine on the metabolism of human hepatocytes. Toxicology in Vitro 5:3, pages 219-224.
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C.N. Allen, E.S. Harpur, T.J.B. Gray & B.H. Hirst. (1991) Toxic effects of non-steroidal anti-inflammatory drugs in a human intestinal epithelial cell line (HCT-8), as assessed by the MTT and neutral red assays. Toxicology in Vitro 5:3, pages 183-191.
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