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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 6
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Original Article

Hepatotoxicity and molecular aspects of hepatocyte function in primary culture

C. Guguen-Guillouzo Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
,
P. Gripon Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
,
Y. Vandenberghe Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
,
F. Lamballe Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
,
D. Ratanasavanh Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
&
A. Guillouzo Unité de Recherches, Hépatologiques U 49 de TINSERM, Hôpital, de Pontchaillou, 35033, Rennes Cedex, France
Pages 773-783 | Published online: 30 Sep 2009

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H.-G. Koebe, S. Pahernik, P. Eyer & F.-W. Schildberg. (1994) Collagen gel immobilization: A useful cell culture technique for long-term metabolic studies on human hepatocytes. Xenobiotica 24:2, pages 95-107.
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Articles from other publishers (17)

Hyunyoung Jeong & Catherine S. Stika. (2020) Methods to study mechanisms underlying altered hepatic drug elimination during pregnancy. Seminars in Perinatology 44:3, pages 151228.
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Erik Eschbach, Shyam S. Chatterjee, Michael Nöldner, Eric Gottwald, Hermann Dertinger, Karl-Friedrich Weibezahn & Gudrun Knedlitschek. (2005) Microstructured scaffolds for liver tissue cultures of high cell density: Morphological and biochemical characterization of tissue aggregates. Journal of Cellular Biochemistry 95:2, pages 243-255.
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GERALDINE A. HAMILTON, CARL WESTMORELAND & ELISABETH GEORGE. (2001) EFFECTS OF MEDIUM COMPOSITION ON THE MORPHOLOGY AND FUNCTION OF RAT HEPATOCYTES CULTURED AS SPHEROIDS AND MONOLAYERS. In Vitro Cellular & Developmental Biology - Animal 37:10, pages 656.
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C. Selden, M. Khalil & H. Hodgson. (2018) Three Dimensional Culture Upregulates Extracellular Matrix Protein Expression in Human Liver Cell Lines - a Step towards Mimicking the Liver in Vivo?. The International Journal of Artificial Organs 23:11, pages 774-781.
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A Denardou-Queneherve, D Grzebyk, Y.F Pouchus, M.P Sauviat, E Alliot, J.F Biard, B Berland & J.F Verbist. (1999) Toxicity of French strains of the dinoflagellate Prorocentrum minimum experimental and natural contaminations of mussels. Toxicon 37:12, pages 1711-1719.
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Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
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H Spielmann, N P Bochkov, L Costa, L Gribaldo, A Guillouzo, J J Heindel, M Karol, R Parchment, W Pfaller, P P Peraita & T Zacharewski. (1998) 13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for organ toxicity.. Environmental Health Perspectives 106:suppl 2, pages 427-439.
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M.B. Thompson. (2016) Bile Acids in the Assessment of Hepatocellular Function. Toxicologic Pathology 24:1, pages 62-71.
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Guo Xinbiao, Ohno Yasuo, Kawanishi Toru, Sunouchi Momoko & Takanaka Akira. (1992) Indium inhibits gap junctional communication between rat hepatocytes in primary culture. Toxicology Letters 60:1, pages 99-106.
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Michael N. Berry, Heather J. Halls & Marlene B. Grivell. (1992) Techniques for pharmacological and toxicological studies with isolated hepatocyte suspensions. Life Sciences 51:1, pages 1-16.
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Jamal Bayad, Denyse Bagrel, Nicole Sabolovic, Jacques Magdalou & Gerard Siest. (1991) Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line. Biochemical Pharmacology 42:7, pages 1345-1351.
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J. Bayad, N. Sabolovic, D. Bagrel, J. Magdalou & G. Siest. (1991) Influence of the isolation method on the stability of differentiated phenotype in cultured rat hepatocytes. Journal of Pharmacological Methods 25:1, pages 85-94.
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L.A.P. Hoogenboom, M.B.M. Oorsprong, T. van Vliet & H.A. Kuiper. (1991) The use of pig hepatocytes for cytotoxicity studies of veterinary drugs: A comparative study with furazolidone and other nitrofurans. Toxicology in Vitro 5:1, pages 31-38.
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Curtis D. Klaassen & Jie Liu. 1991. Metallobiochemistry Part B Metallothionein and Related Molecules. Metallobiochemistry Part B Metallothionein and Related Molecules 567 574 .
Peter R. Sinclair, Erin G. Schuetz, William J. Bement, Sally A. Haugen, Jacqueline F. Sinclair, Brian K. May, Donna Li & Philip S. Guzelian. (1990) Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix. Archives of Biochemistry and Biophysics 282:2, pages 386-392.
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