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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 7
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Original Article

Effects of induction on the metabolism and cytochrome P-450 binding of harman and other β-carbolines

Donald J. Tweedie Department of Biochemistry, University of Louisville, School of Medicine, Louisville, Ky, 40292, USA
,
Russell A. Prough Department of Biochemistry, University of Louisville, School of Medicine, Louisville, Ky, 40292, USA
&
M. Danny Burke Department of Pharmacology, University of Aberdeen, Aberdeen, AB9 1AS, Scotland, UK
Pages 785-796 | Received 01 May 1987, Accepted 04 Dec 1987, Published online: 30 Sep 2009

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Sueli Moreira Mello, Paula Christiane Soubhia, Gabriela Silveira, Nelson Francisco Corrêa-Neto, Rafael Lanaro, José Luiz Costa & Alessandra Linardi. (2019) Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users. Journal of Psychoactive Drugs 51:1, pages 3-11.
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Articles from other publishers (13)

Neda Ahmadinejad & Mostafa Talebi Tari. (2017) Nuclear magnetic and nuclear quadrupole resonance parameters of β-carboline derivatives calculated using density functional theory. Russian Journal of Physical Chemistry A 91:4, pages 733-738.
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Lei Zhao & Michael Wink. (2013) The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype. PeerJ 1, pages e174.
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Hans Rommelspacher, Catrin Wernicke & Jochen Lehmann. 2012. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants 105 113 .
Yoshio Nakagawa, Toshinari Suzuki, Hidemi Ishii, Akio Ogata & Dai Nakae. (2010) Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes. Chemico-Biological Interactions 188:3, pages 393-403.
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Tomás Herraiz, Hugo Guillén & Vicente J. Arán. (2008) Oxidative Metabolism of the Bioactive and Naturally Occurring β-Carboline Alkaloids, Norharman and Harman, by Human Cytochrome P450 Enzymes. Chemical Research in Toxicology 21:11, pages 2172-2180.
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Judith Jiménez, Leticia Riverón-Negrete, Fikrat Abdullaev, Javier Espinosa-Aguirre & Rosario Rodríguez-Arnaiz. (2008) Cytotoxicity of the β-carboline alkaloids harmine and harmaline in human cell assays in vitro. Experimental and Toxicologic Pathology 60:4-5, pages 381-389.
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Ai-Ming Yu. (2008) Indolealkylamines: Biotransformations and Potential Drug–Drug Interactions. The AAPS Journal 10:2.
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Jörg Hümmerich, Christoph Zohm & Wolfgang Pfau. (2004) Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines. Toxicology 199:2-3, pages 231-240.
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W Pfau & K Skog. (2004) Exposure to β-carbolines norharman and harman. Journal of Chromatography B 802:1, pages 115-126.
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Wimal Herath, Julie Rakel Mikell, Daneel Ferreira & Ikhlas Ahmad Khan. (2003) Microbial Metabolites of Harman Alkaloids. Chemical and Pharmaceutical Bulletin 51:6, pages 646-648.
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Jane Marlei Boeira, Alice Fialho Viana, Jaqueline Nascimento Picada & João Antonio Pêgas Henriques. (2002) Genotoxic and recombinogenic activities of the two β-carboline alkaloids harman and harmine in Saccharomyces cerevisiae. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 500:1-2, pages 39-48.
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H. Tsuchiya & T. Hayashi. (2000) A possible link between β -carboline metabolism and infantile autism. Medical Hypotheses 55:3, pages 215-217.
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T. Robinson. 2000. Bioactive Natural Products (Part C). Bioactive Natural Products (Part C) 3 54 .

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