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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 7
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Original Article

The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat

R. Craig Kammerer Department of Pharmacology, The Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California, 90024-1735, USA
,
Debra A. Schmitz Department of Pharmacology, The Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California, 90024-1735, USA
,
Marilyn A. Lampe Department of Pharmacology, The Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California, 90024-1735, USA
&
Kenneth Kloc Department of Pharmacology, The Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California, 90024-1735, USA
Pages 869-881 | Received 07 Sep 1987, Accepted 12 Feb 1988, Published online: 30 Sep 2009

Citations (10)

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Read on this site (4)

B. C. Chung, D. H. Kim, B. H. Jung, K. Eom, W. Slikker & J. Park. (1994) Identification of urinary metabolites of pyrilamine after oral administration to man. Xenobiotica 24:5, pages 451-459.
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D. W. Kelly, C. L. Holder, W. A. Korfmacher, T. A. Getek, J. O. Lay, D. A. Casciano, J. G. Shaddock, H. M. Duhart & W. Slikker. (1992) Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. Xenobiotica 22:12, pages 1367-1381.
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M. A. Lampe & R. C. Kammerer. (1990) Species differences in the metabolism and macromolecular binding of methapyrilene: a comparison of rat, mouse and hamster. Xenobiotica 20:12, pages 1269-1280.
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R. Craig Kammerer & Debra A. Schmitz. (1988) A Comparativel in Vitro Metabolic Study of Methaphenilene and Pyribenzamine. Xenobiotica 18:9, pages 1085-1096.
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Articles from other publishers (6)

Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams & B. Kevin Park. (2008) Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. Journal of Pharmacology and Experimental Therapeutics 326:2, pages 657-671.
Crossref
. 2001. Metabolic Maps. Metabolic Maps 288 295 .
Gurpreet S Ratra, Christopher J Powell, B.Kevin Park, James L Maggs & Suzanne Cottrell. (2000) Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation. Chemico-Biological Interactions 129:3, pages 279-295.
Crossref
Gurpreet S Ratra, Winston A Morgan, Jenny Mullervy, Christopher J Powell & Matthew C Wright. (1998) Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. Toxicology 130:2-3, pages 79-93.
Crossref
Susan M. Bjorge. 1997. Stable Isotopes in Pharmaceutical Research. Stable Isotopes in Pharmaceutical Research 233 242 .
Jeffery B. Press. 1991. Chemistry of Heterocyclic Compounds. Chemistry of Heterocyclic Compounds 397 502 .

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