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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
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Original Article

Oxidative metabolism of propylthiouracil by peroxidases from rat bone marrow

Eibai Lee Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe, 673, Japan
,
Yasuhiro Miki Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe, 673, Japan
,
Mikio Hosokawa Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe, 673, Japan
,
Hiroteru Sayo Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe, 673, Japan
&
Kimio Kariya Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Ikawadani-cho, Nishi-ku, Kobe, 673, Japan
Pages 1135-1142 | Received 08 Dec 1987, Accepted 10 Jun 1988, Published online: 30 Sep 2009

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Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi & Hossein Niknahad. (2019) Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology 42:6, pages 615-623.
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Jack P. Uetrecht. (1996) Section Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Drug-induced lupus: Possible mechanisms and their implications for prediction of which new drugs may induce lupus. Expert Opinion on Investigational Drugs 5:7, pages 851-860.
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J. P. Uetrecht. (1992) The Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug Reactions. Drug Metabolism Reviews 24:3, pages 299-366.
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H. Sayo & M. Saito. (1991) Hydrogen peroxide-dependent oxidative metabolism of 1-methy1-2-mercaptoimidazole (methimazole) catalysed by myeloperoxidase. Xenobiotica 21:9, pages 1217-1224.
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Jack Uetrecht. (1990) Drug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug Reactions. Critical Reviews in Toxicology 20:4, pages 213-235.
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Articles from other publishers (15)

Min Li, Qingfeng He, Li Yao, Xiaofeng Wang, Zhijia Tang, Xiao Zhu, Hai-Shu Lin & Xiaoqiang Xiang. (2021) Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study. Pharmaceuticals 14:11, pages 1194.
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J. Q. Dong, M. V. Varma, A. Wolford, T. Ryder, L. Di, B. Feng, S. G. Terra, K. Sagawa & A. S. Kalgutkar. (2015) Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug Metabolism and Disposition 44:2, pages 209-219.
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Min Chen, Ying Gao, Xiao-Hui Guo & Ming-Hui Zhao. (2012) Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. Nature Reviews Nephrology 8:8, pages 476-483.
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Dana E. Vanderwall, Nancy Yuen, Mohammad Al-Ansari, James Bailey, David Fram, Darren V.S. Green, Stephen Pickett, Giovanni Vitulli, Juan I. Luengo & June S. Almenoff. (2011) Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery – the GSK experience. Drug Discovery Today 16:15-16, pages 646-653.
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Ai-Hua Zhang, Min Chen, Ying Gao, Ming-Hui Zhao & Hai-Yan Wang. (2007) Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. Clinical Immunology 122:2, pages 187-193.
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Lisa Waldhauser & Jack Uetrecht. (1996) Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat. Toxicology 114:2, pages 155-162.
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J. P. Uetrecht & S. P. Spielberg. (1993) Mechanisms of neutropenia: The role of Neutrophil-specific pathways of drug metabolism. Pharmacoepidemiology & Drug Safety 2:S7, pages S37-S42.
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Angela H. Hofstra & Jack P. Uetrecht. (1993) Myeloperoxidase-mediated activation of xenobiotics by human leukocytes. Toxicology 82:1-3, pages 221-242.
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Eibai Lee, Mitsugu Fujita & Kimio Kariya. (1991) Stimulation of phagocytosis in rat polymorphonuclear leukocytes by A23187 is accompanied by activation of myeloperoxidase. Biochemical and Biophysical Research Communications 176:1, pages 364-370.
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A. L. Parke, C. Ioannides, D. F. V. Lewis & D. V. Parke. (1991) Molecular pathology of drug-disease interactions in chronic autoimmune inflammatory diseases. Inflammopharmacology 1:1, pages 3-36.
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Mark A. Sanner & Terry J. Higgins. 1991. 181 190 .
Jack Uetrecht. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 121 132 .
Eibai Lee, Yasuhiro Miki, Hidemi Katsljra & Kimio Kariya. (1990) Mechanism of inactivation of myeloperoxidase by propylthiouracil. Biochemical Pharmacology 39:9, pages 1467-1471.
Crossref
Kimio KARIYA, Yasuhiro MIKI, Yukiko TSURUOKA, Satoko KITANO & Eibai LEE. (1990) Bone Marrow Peroxidases of Spontaneously Hypertensive Rats. Japanese Journal of Pharmacology 53:1, pages 19-23.
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Jack Uetrecht. (1989) Mechanism of hypersensitivityreactions: proposed involvement of reactive metabolites generated by activated leukocytes. Trends in Pharmacological Sciences 10:11, pages 463-467.
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