Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
Submit an article Journal homepage
31
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Metabolism of a New Positive Inotropic Agent, 3,4-Dihydro-6-[4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl]-2(1H)-Quinolinone (Opc-8212) in the Rat, Mouse, Dog, Monkey and Human

Gohachiro Miyamoto Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
,
Hiroyuki Sasabe Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
,
Noriko Tominaga Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
,
Noriyoshi Uegaki Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
,
Michiaki Tominaga Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
&
Takefumi Shimizu Laboratories of Drug Metabolism and Analytical Research, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-01, Japan
Pages 1143-1155 | Received 01 Sep 1987, Accepted 19 Apr 1988, Published online: 30 Sep 2009

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
Read now
P. J. Jackson, R. D. Brownsill, A. R. Taylor, G. Resplandy, B. Walther & H. R. Schwietert. (1996) Identification of trimetazidine metabolites in human urine and plasma. Xenobiotica 26:2, pages 221-228.
Read now

Articles from other publishers (10)

T. Ramesh, P. Nageswara Rao, R. Nageswara Rao & K. V. V. Satyanarayana. (2013) Hydrophilic interaction liquid chromatography for the determination of vesnarinone on dried blood spots; application to pharmacokinetics in rats. New Journal of Chemistry 37:10, pages 3092.
Crossref
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
Crossref
Randall R. Miller, George A. Doss & Ralph A. Stearns. (2004) IDENTIFICATION OF A HYDROXYLAMINE GLUCURONIDE METABOLITE OF AN ORAL HYPOGLYCEMIC AGENT. Drug Metabolism and Disposition 32:2, pages 178-185.
Crossref
Kumara S Sekar & Steven L Bramer. (2003) Extended application of an LC–MS/MS method for the analysis of vesnarinone and its metabolites in human urine and dialysate fluid. Journal of Pharmaceutical and Biomedical Analysis 33:4, pages 711-717.
Crossref
PrasadN.V. Tata, KarlS. Schorno, T.Douglas Cowart & StevenL. Bramer. (1999) LC/MS/MS analysis of vesnarinone and its principal metabolites in plasma and urine. Journal of Pharmaceutical and Biomedical Analysis 18:6, pages 1037-1045.
Crossref
Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow & A. Kluge. 1999. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 713 726 .
Christoph Wandel, Chim C. Lang, Doug C. Cowart, Armand F. Girard, Steve Bramer, David A. Flockhart & Alastair J.J. Wood. (1998) Effect of CYP3A inhibition on vesnarinone metabolism in humans*. Clinical Pharmacology & Therapeutics 63:5, pages 506-511.
Crossref
Michael J. Parnham, Vera M. Kolb, Shradha Sinha, Sudha Jain, A. Das, J. H. Wang, E. J. Lien, Berend Olivier, Jan Mos, Maikel Raghoebar, Paul de Koning, Marianne Mak, H. Hugh Fudenberg, Giancarlo Pizza & Caterina de VinciBerend Olivier, Jan Mos, Maikel Raghoebar, Paul de Koning & Marianne Mak. 1994. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques 167 308 .
Martin Rudolph & Gerhard Schmiedel. (1992) Analysis of [14C]-saterinone and its metabolites in dog plasma, urine and bile by high-performance liquid chromatography with radioactivity and fluorescence detection and by mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 10:4, pages 295-302.
Crossref
N. de Lange & Μ. Raghoebar. (1990) DISTRIBUTION OF RADIOACTIVELY LABELLED ELTOPRAZINE IN RAT AND DOG. Drug Metabolism and Drug Interactions 8:1-2.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.