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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 10
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Original Article

Medicinal Azides. Part 3. The Metabolism of the Investigational Antitumour Agent Meta-Azidopyrimethamine in Mouse Tissue in vitro

Farhad Kamali Cancer Research Campaign Experimental Chemotherapy Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, B4 7ET, UK
,
Andreas Gescher Cancer Research Campaign Experimental Chemotherapy Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, B4 7ET, UK
&
John A. Slack Cancer Research Campaign Experimental Chemotherapy Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham, B4 7ET, UK
Pages 1157-1164 | Received 04 May 1988, Accepted 24 Jun 1988, Published online: 30 Sep 2009

Citations (15)

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D. Nicholls, A. Gescher & R. J. Griffin. (1991) Medicinal azides. Part 8. The in vitro metabolism of p-substituted phenyl azides. Xenobiotica 21:7, pages 935-943.
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Articles from other publishers (14)

Jiali Sun, Zhilin Liu, Haochen Yao, Honglei Zhang, Mengfei Zheng, Na Shen, Jianjun Cheng, Zhaohui Tang & Xuesi Chen. (2023) Azide‐Masked Resiquimod Activated by Hypoxia for Selective Tumor Therapy. Advanced Materials 35:29.
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Federica Borghi, Ibrahim E. Çelik, Phillip Biallas, Fabia Mittendorf & Stefan F. Kirsch. (2020) Expanding the Versatile Reactivity of Diazido Malonic Acid Esters and Amides: Decarboxylation and Imine Formation. European Journal of Organic Chemistry 2020:28, pages 4389-4398.
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Liam J. O’ConnorIshna N. MistrySarah L. CollinsLisa K. FolkesGraham BrownStuart J. Conway & Ester M. Hammond. (2016) CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes. ACS Central Science 3:1, pages 20-30.
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Pijus K. Sasmal, Susana Carregal‐Romero, Alice A. Han, Craig N. Streu, Zhijie Lin, Kazuhiko Namikawa, Samantha L. Elliott, Reinhard W. Köster, Wolfgang J. Parak & Eric Meggers. (2012) Catalytic Azide Reduction in Biological Environments. ChemBioChem 13:8, pages 1116-1120.
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Štefan Bezek, Marián Kukan & Pavol Bohov. (1994) Hepatobiliary Disposition of 3′-Azido-3′-deoxythymidine (AZT) in the Rat: Effect of Phenobarbitone Induction. Journal of Pharmacy and Pharmacology 46:7, pages 575-580.
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F Kamali & C Edwards. (1993) Conversion of flosequinan to the sulphone metabolite in subcellular fractions of human liver, in-vitro. Journal of Pharmacy and Pharmacology 45:6, pages 578-580.
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V.A. Eagling, J.L. Howe, M.J. Barry & D.J. Back. (1994) The metabolism of zidovudine by human liver microsomes in vitro: Formation of 3′-amino-3′-deoxythymidine. Biochemical Pharmacology 48:2, pages 267-276.
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Roger J. Griffin. 1994. 121 232 .
F. Kamali. (1993) The effect of probenecid on paracetamol metabolism and pharmacokinetics. European Journal of Clinical Pharmacology 45:6, pages 551-553.
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A. Naik, W.J. Irwin & R.J. Griffin. (1993) The reduction of azidoprofen: A model for a soft anti-inflammatory drug for topical application. International Journal of Pharmaceutics 89:1, pages 51-63.
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F. Kamali & M. D. Rawlins. (2006) Influence of probenecid and paracetamol (acetaminophen) on zidovudine glucuronidation in human liver in vitro . Biopharmaceutics & Drug Disposition 13:6, pages 403-409.
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Neil D. Baker, Roger J. Griffin, William J. Irwin, Uwe Reichert & Rainer Schmidt. (1991) Uptake, cytotoxicity and metabolism of m-azidopyrimethamine and related lipophilic antifolates in SV-K14 human keratinocytes in vivo. Biochemical Pharmacology 42, pages S39-S46.
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N.D. Baker, R.J. Griffin & W.J. Irwin. (1990) The percutaneous absorption of m-azidopyrimethamine: A soft antifolate for topical use. International Journal of Pharmaceutics 65:1-2, pages 115-125.
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N.D. Baker, R.J. Griffin, W.J. Irwin & J.A. Slack. (1989) The reduction of aryl azides by dithiothreitol: a model for bioreduction of aromatic azido-substituted drugs. International Journal of Pharmaceutics 52:3, pages 231-238.
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