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Hidetaka Kamimura & Satoshi Ito. (2016) Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound. Xenobiotica 46:6, pages 557-569.
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Johann W. Faigle, Irmgard BÖttcher, Jacques Godbillon, Hans P. Kriemler, Erich Schlumpf, Werner Schneider, Alfred Schweizer, Hiltrud Stierlin & Tammo Winkler. (1988) A New Metabolite of Diclofenac Sodium in Human Plasma. Xenobiotica 18:10, pages 1191-1197.
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Articles from other publishers (20)
Angela A. M. Kämpfer, Ume-Kulsoom Shah, Shui L. Chu, Mathias Busch, Veronika Büttner, Ruiwen He, Barbara Rothen-Rutishauser, Roel P. F. Schins & Gareth J. Jenkins. (2022) Interlaboratory comparison of an intestinal triple culture to confirm transferability and reproducibility. In vitro models.
Crossref
Crossref
Yingying Ma, Shuhua Zhang, Yu Wang, Zhenlin Jiang, Nengshuo Fu, Zhuo Yang & Yongjun Mao. (2020) The Structure and Release Kinetics of Ca–Al Layered Double Hydroxide by Intercalating with Diclofenac Sodium. Nano 15:03, pages 2050028.
Crossref
Crossref
Christoph Thiel, Ines Smit, Vanessa Baier, Henrik Cordes, Brigida Fabry, Lars Mathias Blank & Lars Kuepfer. (2018) Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations. npj Systems Biology and Applications 4:1.
Crossref
Crossref
C. E. Wilson, A. P. Dickie, K. Schreiter, R. Wehr, E. M. Wilson, J. Bial, N. Scheer, I. D. Wilson & R. J. Riley. (2018) The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice. Archives of Toxicology 92:6, pages 1953-1967.
Crossref
Crossref
Hidetaka Kamimura, Satoshi Ito, Kohei Nozawa, Shota Nakamura, Hiroyuki Chijiwa, Shin-ichiro Nagatsuka, Miyuki Kuronuma, Yasuyuki Ohnishi, Hiroshi Suemizu & Shin-ichi Ninomiya. (2015) Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice with Humanized Livers. Drug Metabolism and Disposition 43:3, pages 309-316.
Crossref
Crossref
Takako Ohkura, Kunihiro Ohta, Takuya Nagao, Kumiko Kusumoto, Akiko Koeda, Tadayoshi Ueda, Tomoko Jomura, Takeshi Ikeya, Emiko Ozeki, Kazuki Wada, Kazushi Naitoh, Yukiko Inoue, Naoki Takahashi, Hisakazu Iwai, Hiroshi Arakawa & Takuo Ogihara. (2014) Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism. Drug Metabolism and Pharmacokinetics 29:5, pages 373-378.
Crossref
Crossref
Jan Simon Boerma, Nico P.E. Vermeulen & Jan N.M. Commandeur. (2014) One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2′-(glutathion-S-yl)-deschloro-diclofenac. Chemico-Biological Interactions 207, pages 32-40.
Crossref
Crossref
Kirstin Thelen, Katrin Coboeken, Stefan Willmann, Rolf Burghaus, Jennifer B. Dressman & Jörg Lippert. (2011) Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions. Journal of Pharmaceutical Sciences 100:12, pages 5324-5345.
Crossref
Crossref
Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
Crossref
Crossref
A.C. Johnson, V. Keller, R.J. Williams & A. Young. (2007) A practical demonstration in modelling diclofenac and propranolol river water concentrations using a GIS hydrology model in a rural UK catchment. Environmental Pollution 146:1, pages 155-165.
Crossref
Crossref
Yusuke Hara, Miki Nakajima, Ken-ichi Miyamoto & Tsuyoshi Yokoi. (2007) Morphine Glucuronosyltransferase Activity in Human Liver Microsomes is Inhibited by a Variety of Drugs that are Co-administered with Morphine. Drug Metabolism and Pharmacokinetics 22:2, pages 103-112.
Crossref
Crossref
Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du & Hua Zhong. (2005) DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES. Drug Metabolism and Disposition 33:6, pages 706-713.
Crossref
Crossref
Ronald Esser, Carol Berry, Zhengming Du, Janet Dawson, Alyson Fox, Roger A Fujimoto, William Haston, Earl F Kimble, Julie Koehler, Jane Peppard, Elizabeth Quadros, Joseph Quintavalla, Karen Toscano, Laszlo Urban, John van Duzer, Xiaoli Zhang, Siyuan Zhou & Paul J Marshall. (2005) Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. British Journal of Pharmacology 144:4, pages 538-550.
Crossref
Crossref
David J. Carlile, Nancy Hakooz, Martin K. Bayliss & J. Brian Houston. (2001)
Microsomal prediction of
in vivo
clearance of CYP2C9 substrates in humans
. British Journal of Clinical Pharmacology 47:6, pages 625-635.
Crossref
Crossref
Hanspeter E. Killer, François X. Borruat, Bruno K. Blumer, Carl P. Herbort & Arthur Jauch. (1998) Corneal penetration of diclofenac from a fixed combination of diclofenac-gentamicin eyedrops. Journal of Cataract and Refractive Surgery 24:10, pages 1365-1370.
Crossref
Crossref
J.O. Auler Jr.E.B. Espada, E. Crivelli, T.B.G. Quintavalle, A. Kurata, N.A.G. Stolf, A.M. Issy, O.E.D. Paschoa, M. Danhof, D.D. Breimer, D.A.F. Chamone & S.R.C.J. Santos. (1997) Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass. Brazilian Journal of Medical and Biological Research 30:3, pages 369-374.
Crossref
Crossref
Dorene A. O'Hara. (1993) INJECTABLE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS. Anesthesiology Clinics of North America 11:4, pages 815-829.
Crossref
Crossref
I. Wiesenberg-Boettcher, J. Pfeilschifter, A. Schweizer, A. Sallmann & P. Wenk. (1991) Pharmacological properties of five diclofenac metabolites identified in human plasma. Agents and Actions 34:1-2, pages 135-137.
Crossref
Crossref
A. Salama, B. Göttsche & C. Mueller-Eckhardt. (2008) Autoantibodies and drug-or metabolite-dependent antibodies in patients with diclofenac-induced immune haemolysis. British Journal of Haematology 77:4, pages 546-549.
Crossref
Crossref
K.W.M. Zuurbier, A.R.J. Bakkenist, R.H. Fokkens, N.M.M. Nibbering, R. Wever & A.O. Muijsers. (1990) Interaction of myeloperoxidase with diclofenac. Biochemical Pharmacology 40:8, pages 1801-1808.
Crossref
Crossref