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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 1
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Research Article

Pharmacokinetics of nilvadipine, a new dihydropyridine calcium antagonist, in mice, rats, rabbits and dogs

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Pages 21-28 | Received 12 Dec 1986, Published online: 22 Sep 2008

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Amy C. Brown, Janet Onopa, Peter Holck, Pakieli Kaufusi, Derek Kabasawa, Winston J. Craig, Klaus Dragull, Arieh M. Levine & Jonathan D. Baker. (2007) Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii. Clinical Toxicology 45:5, pages 549-556.
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T. Teramura, T. Watanabe, S. Higuchi & K. Hashimoto. (1995) Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human. Xenobiotica 25:11, pages 1237-1246.
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A. G. Renwick. (1993) Data‐derived safety factors for the evaluation of food additives and environmental contaminants. Food Additives & Contaminants 10:3, pages 275-305.
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Sergey V. Geodakyan. (1993) Methodological Approach in the Study of Anticancer Drug Metabolism: Qualitative Considerations. Drug Metabolism Reviews 25:1-2, pages 153-172.
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A. G. Renwick. (1991) Safety factors and establishment of acceptable daily intakes. Food Additives & Contaminants 8:2, pages 135-149.
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Dennis A. Smith. (1991) Species Differences in Metabolism and Pharmacokinetics: Are We Close to an Understanding?. Drug Metabolism Reviews 23:3-4, pages 355-373.
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M. Pellegatti, P. Grossi, J. Ayrton, G. L. Evans & A. J. Harker. (1990) Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog. Xenobiotica 20:8, pages 765-777.
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B. K. Park & N. R. Kitteringham. (1990) Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications. Xenobiotica 20:11, pages 1171-1185.
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S. Terashita, Y. Tokuma, M. Sekiguchi & H. Noguchi. (1989) Sex differences in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats. Xenobiotica 19:11, pages 1221-1229.
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Articles from other publishers (9)

Toshiro SakaiKazuhiro SakoMasahiro Hayashi. (2011) Factors Affecting the Absorption of Nilvadipine from Disintegration-Controlled Matrix Tablet in Dogs. Biological and Pharmaceutical Bulletin 34:11, pages 1731-1736.
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Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, Satoshi Ueda, Yuji Tokunaga, Rinta Ibuki, Kazutaka Higaki & Toshikiro Kimura. (2006) Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation. Journal of Controlled Release 112:1, pages 51-56.
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Shahab Bohlooli, Fariborz Keyhanfar & Massoud Mahmoudian. (2004) Pharmacokinetics of mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats. Biopharmaceutics & Drug Disposition 25:4, pages 187-191.
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Daniel Paris, Amita Quadros, James Humphrey, Nikunj Patel, Robert Crescentini, Fiona Crawford & Michael Mullan. (2004) Nilvadipine antagonizes both Aβ vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic mice. Brain Research 999:1, pages 53-61.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Stefan Russmann, Yann Barguil, Pierre Cabalion, Marina Kritsanida, Daniel Duhet & Bernhard H Lauterburg. (2003) Hepatic injury due to traditional aqueous extracts of kava root in New Caledonia. European Journal of Gastroenterology & Hepatology 15:9, pages 1033-1036.
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Iftekhar Mahmood. (2002) Interspecies Scaling: Predicting Oral Clearance in Humans. American Journal of Therapeutics 9:1, pages 35-42.
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Toshiharu Sakai, Toshio Teramura, Hideaki Okamiya & Osamu Inagaki. (2007) A Review on Barnidipine: A Novel Calcium Antagonist. Cardiovascular Drug Reviews 15:4, pages 273-290.
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Yoji Tokuma & Hideyo Noguchi. (1995) Stereoselective pharmacokinetics of dihydropyridine calcium antagonists. Journal of Chromatography A 694:1, pages 181-193.
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