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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 1
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Research Article

Metabolism of chlorpromazine and promazine in vitro: Isolation and characterization of N-oxidation products

A. H. Beckett Chelsea Department of Pharmacy, King's College London (KQC), University of London, Manresa Road, London, SW3 6LX, UK
,
G. E. Navas Chelsea Department of Pharmacy, King's College London (KQC), University of London, Manresa Road, London, SW3 6LX, UK; Department of Pharmaceutical Analysis, Universidad de Panama, Panama, Republic of Panama
&
A. J. Hutt Chelsea Department of Pharmacy, King's College London (KQC), University of London, Manresa Road, London, SW3 6LX, UK; Department of Pharmacy, Brighton Polytechnic, Moulsecoomb, Brighton, BN2 4GJ, UK
Pages 61-74 | Received 24 Dec 1986, Published online: 22 Sep 2008

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M. C. Dumasia. (2003) Identification of some -hydroxylated metabolites of (±)-3,4-methylenedioxymethamphetamine in horse urine by gas chromatography-mass spectrometry. Xenobiotica 33:10, pages 1013-1025.
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Articles from other publishers (17)

Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Surachai NgamratanapaiboonPracha Yambangyang. (2021) Quantification of antipsychotic biotransformation in brain microvascular endothelial cells by using untargeted metabolomics. Drug Discoveries & Therapeutics 15:6, pages 317-324.
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Babiker M. EH-Haj. (2021) Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors. Molecules 26:7, pages 1917.
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Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Kenji Tsujikawa, Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko T. Iwata & Hiroyuki Inoue. (2009) Degradation of N-hydroxy-3,4-methylenedioxymethamphetamine in aqueous solution and its prevention. Forensic Science International 193:1-3, pages 106-111.
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Claire Davis. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 6 .
Donald J. AbrahamC. Anthony Altar, Arnold R. Martin & Andrew Thurkauf. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 599 672 .
Ellen W. Baxter & Allen B. Reitz. 2004. Organic Reactions. Organic Reactions 1 714 .
R. Whelpton. 1997. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists 451 480 .
William H. Halliwell. (2016) Cationic Amphiphilic Drug-Induced Phospholipidosis. Toxicologic Pathology 25:1, pages 53-60.
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Urmila P. Kodavanti, Virginia G. Lockard & Harihara M. Mehendale. (1990) In vivo toxicity and pulmonary effects of promazine and chlorpromazine in rats. Journal of Biochemical Toxicology 5:4, pages 245-251.
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Marja‐Liisa Dahl‐Puustinen, Anna Åberg‐Wistedt & Leif Bertilsson. (2009) Glucuronidation of Amitriptyline in Man in Vivo . Pharmacology & Toxicology 65:1, pages 37-39.
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R. T. Coutts & G. B. Baker. (1989) Implications of chirality and geometric isomerism in some psychoactive drugs and their metabolites. Chirality 1:2, pages 99-120.
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Gun Il Kang & Suk Kil Hong. (1988) Biotransformation of tranylcypromine in rat liver microsomes. Archives of Pharmacal Research 11:4, pages 292-300.
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Marja-Liisa Dahl-Puustinen & Leif Bertilsson. (1987) Formation of a Quaternary N-Glucuronide of Amitriptyline in Human Liver Microsomes. Pharmacology & Toxicology 61:5, pages 342-346.
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Etienne Dumont, Christer von Bahr, Thomas L. PerryJr.Jr. & Leif Bertilsson. (1987) Glucuronidation of the Enantiomers of E-10-Hydroxynortriptyline in Human and Rat Liver Microsomes. Pharmacology & Toxicology 61:5, pages 335-341.
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C. A. A. van Boeckel. (2013) Some recent applications of carbohydrates and their derivatives in the pharmaceutical industry. Recueil des Travaux Chimiques des Pays-Bas 105:2, pages 35-53.
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