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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 1
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Original Article

The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats

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Pages 25-32 | Received 30 Aug 1987, Accepted 03 Jul 1988, Published online: 30 Sep 2009

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Erik Bannert, Tanja Tesch, Jeannette Kluess, Janine Winkler, Jana Frahm, Susanne Kersten, Stefan Kahlert, Lydia Renner, Hermann-Josef Rothkötter & Sven Dänicke. (2018) On the distribution and metabolism of Fusarium-toxins along the gastrointestinal tract of endotoxaemic pigs. Archives of Animal Nutrition 72:3, pages 163-177.
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Qinghua Wu, Vlastimil Dohnal, Lingli Huang, Kamil Kuča & Zonghui Yuan. (2010) Metabolic pathways of trichothecenes. Drug Metabolism Reviews 42:2, pages 250-267.
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JamesJ. Pestka & AlexaT. Smolinski. (2005) Deoxynivalenol: Toxicology and Potential Effects on Humans. Journal of Toxicology and Environmental Health, Part B 8:1, pages 39-69.
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R. Hedman, H. Pettersson & J.E. Lindberg. (1997) Absorption and metabolism of nivalenol in pigs. Archiv für Tierernaehrung 50:1, pages 13-24.
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Articles from other publishers (31)

Yu Sun, Jun Jiang, Peiqiang Mu, Ruqin Lin, Jikai Wen & Yiqun Deng. (2022) Toxicokinetics and metabolism of deoxynivalenol in animals and humans. Archives of Toxicology 96:10, pages 2639-2654.
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Francesco Crudo, Georg Aichinger, Jovana Mihajlovic, Elisabeth Varga, Luca Dellafiora, Benedikt Warth, Chiara Dall’Asta, David Berry & Doris Marko. (2021) In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship. Archives of Toxicology 95:7, pages 2533-2549.
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Lingling Wang, Jun Wu, Zhiwen Liu, Yutao Shi, Jinqiu Liu, Xiaofan Xu, Shuxian Hao, Peiqiang Mu, Fengru Deng & Yiqun Deng. (2019) Aflatoxin B1 Degradation and Detoxification by Escherichia coli CG1061 Isolated From Chicken Cecum. Frontiers in Pharmacology 9.
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Bingxuan Jia, Song Yu, Qinghua Wu & Aibo Wu. 2019. Food Safety & Mycotoxins. Food Safety & Mycotoxins 79 100 .
Winnie-Pui-Pui Liew & Sabran Mohd-Redzwan. (2018) Mycotoxin: Its Impact on Gut Health and Microbiota. Frontiers in Cellular and Infection Microbiology 8.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Sarah De Saeger, Gunnar Sundstøl Eriksen, Peter Farmer, Jean‐Marc Fremy, Yun Yun Gong, Karsten Meyer, Hanspeter Naegeli, Dominique Parent‐Massin, Ivonne Rietjens, Hans van Egmond, Andrea Altieri, Mari Eskola, Petra Gergelova, Luisa Ramos Bordajandi, Bistra Benkova, Barbara Dörr, Athanasios Gkrillas, Nicklas Gustavsson, Mathijs van Manen & Lutz Edler. (2017) Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFSA Journal 15:9.
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James Pestka, Erica Clark, Heidi Schwartz-Zimmermann & Franz Berthiller. (2017) Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse. Toxins 9:8, pages 240.
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Cheng Ji, Yu Fan & Lihong Zhao. (2016) Review on biological degradation of mycotoxins. Animal Nutrition 2:3, pages 127-133.
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Kun Lu, Ridwan Mahbub & James G. Fox. (2015) Xenobiotics: Interaction with the Intestinal Microflora. ILAR Journal 56:2, pages 218-227.
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Heidi E. Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Veronika Slavik, Wulf-Dieter Moll & Franz Berthiller. (2014) Deoxynivalenol (DON) sulfonates as major DON metabolites in rats: from identification to biomarker method development, validation and application. Analytical and Bioanalytical Chemistry 406:30, pages 7911-7924.
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Marc Maresca. (2013) From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol. Toxins 5:4, pages 784-820.
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Takumi Yoshizawa. (2013) Thirty-five Years of Research on Deoxynivalenol, a Trichothecene Mycotoxin: with Special Reference to Its Discovery and Co-occurrence with Nivalenol in Japan. Food Safety 1:1, pages 2013002-2013002.
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Veronika Nagl, Heidi Schwartz, Rudolf Krska, Wulf-Dieter Moll, Siegfried Knasmüller, Mathias Ritzmann, Gerhard Adam & Franz Berthiller. (2012) Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. Toxicology Letters 213:3, pages 367-373.
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Petr Karlovsky. (2011) Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives. Applied Microbiology and Biotechnology 91:3, pages 491-504.
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Veronica M.T. Lattanzio, Michele Solfrizzo, Annalisa De Girolamo, Sofía N. Chulze, Adriana M. Torres & Angelo Visconti. (2011) LC–MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat. Journal of Chromatography B 879:11-12, pages 707-715.
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Paul C. Turner, Richard P. Hopton, Kay L.M. White, Julie Fisher, Janet E. Cade & Christopher P. Wild. (2011) Assessment of deoxynivalenol metabolite profiles in UK adults. Food and Chemical Toxicology 49:1, pages 132-135.
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Jiří Skládanka, Jan Nedělník, Vojtěch Adam, Petr Doležal, Hana Moravcová & Vlastimil Dohnal. (2010) Forage as a Primary Source of Mycotoxins in Animal Diets. International Journal of Environmental Research and Public Health 8:1, pages 37-50.
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Hai Yu, Ting Zhou, Jianhua Gong, Christopher Young, Xiaojun Su, Xiu-Zhen Li, Honghui Zhu, Rong Tsao & Raymond Yang. (2010) Isolation of deoxynivalenol-transforming bacteria from the chicken intestines using the approach of PCR-DGGE guided microbial selection. BMC Microbiology 10:1.
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J. Pestka. (2010) Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol. World Mycotoxin Journal 3:4, pages 323-347.
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Paul C. Turner, Richard P. Hopton, Yannick Lecluse, Kay L. M. White, Julie Fisher & Pierre Lebailly. (2010) Determinants of Urinary Deoxynivalenol and De-epoxy Deoxynivalenol in Male Farmers from Normandy, France. Journal of Agricultural and Food Chemistry 58:8, pages 5206-5212.
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Anna Vasatkova, Sarka Krizova, Vojtech Adam, Ladislav Zeman & Rene Kizek. (2009) Changes in Metallothionein Level in Rat Hepatic Tissue after Administration of Natural Mouldy Wheat. International Journal of Molecular Sciences 10:3, pages 1138-1160.
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James J. Pestka & Chidozie J. Amuzie. (2008) Tissue distribution and proinflammatory cytokine gene expression following acute oral exposure to deoxynivalenol: Comparison of weanling and adult mice. Food and Chemical Toxicology 46:8, pages 2826-2831.
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Xianai Wu, Patricia Murphy, Joan Cunnick & Suzanne Hendrich. (2007) Synthesis and characterization of deoxynivalenol glucuronide: Its comparative immunotoxicity with deoxynivalenol. Food and Chemical Toxicology 45:10, pages 1846-1855.
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James J. Pestka. (2007) Deoxynivalenol: Toxicity, mechanisms and animal health risks. Animal Feed Science and Technology 137:3-4, pages 283-298.
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M.E. Gouze, J. Laffitte, P. Rouimi, N. Loiseau, I.P. Oswald & P. Galtier. (2006) Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. Food and Chemical Toxicology 44:4, pages 476-483.
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R. Shapira & N. Paster. 2004. Mycotoxins in Food. Mycotoxins in Food 190 223 .
F.A Meky, P.C Turner, A.E Ashcroft, J.D Miller, Y.-L Qiao, M.J Roth & C.P Wild. (2003) Development of a urinary biomarker of human exposure to deoxynivalenol. Food and Chemical Toxicology 41:2, pages 265-273.
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Nick G Coldham, Laurence C Howells, Annalisa Santi, Clara Montesissa, Claudia Langlais, Laurence J King, David D Macpherson & Maurice J Sauer. (1999) Biotransformation of genistein in the rat: elucidation of metabolite structure by product ion mass fragmentologyn. The Journal of Steroid Biochemistry and Molecular Biology 70:4-6, pages 169-184.
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Petr Karlovsky. (1999) Biological detoxification of fungal toxins and its use in plant breeding, feed and food production. Natural Toxins 7:1, pages 1-23.
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D. Deepak, J. F. Grove, E. Haslam, A. Khare, N. K. Khare & S. SrivastavaJ. F. Grove. 1996. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products 1 70 .
Birgit Kollarczik, Manfred Gareis & Monika Hanelt. (2006) In vitro transformation of the Fusarium mycotoxins deoxynivalenol and zearalenone by the normal gut microflora of pigs . Natural Toxins 2:3, pages 105-110.
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