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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 1
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Original Article

Comparative microsomal oxidation of febantel and its metabolite fenbendazole in various animal species

Clara Montesissa Institute of Veterinary Phamacology and Toxicology University of Milan, Via Celoria 10, 20133, Milan, Italy
,
Jose Malvisi Stracciari Institute of Pharmacology, Pharmacokinetics and Toxicology, Fac. of Vet. Medicine, Strada Maggiore 45, 40125, Bologna, Italy
,
Luigi Fadini Institute of Veterinary Phamacology and Toxicology University of Milan, Via Celoria 10, 20133, Milan, Italy
&
Carlo Beretta Institute of Veterinary Phamacology and Toxicology University of Milan, Via Celoria 10, 20133, Milan, Italy
Pages 97-100 | Received 24 Apr 1988, Accepted 18 Aug 1988, Published online: 30 Sep 2009

Citations (15)

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Young-Heun Jung, Dong-Cheol Lee, Jong Oh Kim & Ju-Hyun Kim. (2022) Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes. Xenobiotica 52:9-11, pages 986-996.
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Federica Vacondio, Claudia Silva, Marco Mor & Bernard Testa. (2010) Qualitative structure-metabolism relationships in the hydrolysis of carbamates. Drug Metabolism Reviews 42:4, pages 551-589.
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Carlos E. Lanusse & Roger K. Prichard. (1993) Clinical Pharmacokinetics and Metabolism of Benzimidazole Anthelmintics in Ruminants. Drug Metabolism Reviews 25:3, pages 235-279.
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Articles from other publishers (12)

Paula Ichinose, María Victoria Miró, Karen Larsen, Carlos Lanusse, Adrián Lifschitz & Guillermo Virkel. (2022) Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine. Veterinary Research Communications 47:2, pages 803-815.
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Fatemeh Mohammadnejad, Fatemeh Ghaffarifar, Abdolhossein Dalimi & Zuhair Mohammad Hassan. (2015) The development of new treatment options for echinococcosis. Reviews in Medical Microbiology 26:4, pages 154-162.
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Tatiana Küster, Britta Stadelmann, Denise Aeschbacher & Andrew Hemphill. (2014) Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. International Journal of Antimicrobial Agents 43:4, pages 335-342.
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Zhexue Wu, Doohyun Lee, Jeongmin Joo, Jung-Hoon Shin, Wonku Kang, Sangtaek Oh, Do Yup Lee, Su-Jun Lee, Sung Su Yea, Hye Suk Lee, Taeho Lee & Kwang-Hyeon Liu. (2013) CYP2J2 and CYP2C19 Are the Major Enzymes Responsible for Metabolism of Albendazole and Fenbendazole in Human Liver Microsomes and Recombinant P450 Assay Systems. Antimicrobial Agents and Chemotherapy 57:11, pages 5448-5456.
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Gunnar Carlsson, Johan Patring, Jenny Kreuger, Leif Norrgren & Agneta Oskarsson. (2013) Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos. Aquatic Toxicology 126, pages 30-41.
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Bettencourt P.S. Capece, Guillermo L. Virkel & Carlos E. Lanusse. (2009) Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications. The Veterinary Journal 181:3, pages 241-250.
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G. Virkel, A. Lifschitz, J. Sallovitz, A. Pis & C. Lanusse. (2004) COMPARATIVE HEPATIC AND EXTRAHEPATIC ENANTIOSELECTIVE SULFOXIDATION OF ALBENDAZOLE AND FENBENDAZOLE IN SHEEP AND CATTLE. Drug Metabolism and Disposition 32:5, pages 536-544.
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Miwa OkamuraTakao Watanabe, Yoko Kashida, Noboru Machida & Kunitoshi Mitsumori. (2016) Possible Mechanisms Underlying the Testicular Toxicity of Oxfendazole in Rats. Toxicologic Pathology 32:1, pages 1-8.
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C. NEBBIA. (2001) Biotransformation Enzymes as Determinants of Xenobiotic Toxicity in Domestic Animals. The Veterinary Journal 161:3, pages 238-252.
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Mads Bjelke Petersen & Christian Friis. (2000) Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs. American Journal of Veterinary Research 61:5, pages 573-576.
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L. BAERT, S. VAN POUCKE, H. VERMEERSCH, J. P. REMON, J. VERCRUYSSE, P. BASTIAENSEN & P. DE BACKER. (2008) Pharmacokinetics and anthelmintic efficacy of febantel in the racing pigeon (Columba livia). Journal of Veterinary Pharmacology and Therapeutics 16:2, pages 223-231.
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C. E. LANUSSE, B. NARE, L. H. GASCON & R. K. PRICHARD. (1992) Bioconversion of netobimin pro-drug by gastrointestinal fluids of ruminants. European Journal of Drug Metabolism and Pharmacokinetics 17:2, pages 121-128.
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