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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 2
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Original Article

Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism

G. Muralidharan College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
,
K. K. Midha College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
,
G. McKay College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
,
E. M. Hawes College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 0W0, Canada
&
T. Inaba Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
Pages 189-197 | Received 30 Mar 1988, Accepted 05 Oct 1988, Published online: 30 Sep 2009

Citations (9)

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G. Muralidharan, E. M. Hawes, G. McKay & K. K. Midha. (1991) Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase. Xenobiotica 21:11, pages 1441-1450.
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Articles from other publishers (8)

Atsushi Kawase, Akiyuki Fujii, Makiko Negoro, Ryosuke Akai, Miki Ishikubo, Hiroshi Komura & Masahiro Iwaki. (2008) Differences in Cytochrome P450 and Nuclear Receptor mRNA Levels in Liver and Small Intestines between SD and DA Rats. Drug Metabolism and Pharmacokinetics 23:3, pages 196-206.
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Nuggehally R. Srinivas. (2006) Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications. Biomedical Chromatography 20:6-7, pages 466-491.
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Hiroshi Komura & Masahiro Iwaki. (2005) Pharmacokinetics and Metabolism of Metoprolol and Propranolol in the Female DA and Female Wistar Rat: The Female DA Rat Is Not Always an Animal Model for Poor Metabolizers of CYP2D6. Journal of Pharmaceutical Sciences 94:2, pages 397-408.
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Fraser B Ross, Steven C Wallis & Maree T Smith. (2000) Co-administration of sub-antinociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain 84:2, pages 421-428.
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Charles V. Vorhees, Tracy M. Reed, Mary A. Schilling, J.Edward Fisher, Mary S. Moran, Gregg D. Cappon & Daniel W. Nebert. (1998) Cyp2d1 Polymorphism in Methamphetamine-Treated Rats. Neurotoxicology and Teratology 20:3, pages 265-273.
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Brian C. Foster, D. Lynden Wilson, Terry D. Cyr, James Moffatt & Harpal S. Buttar. (1995) The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice. Biopharmaceutics & Drug Disposition 16:1, pages 1-11.
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H.M. Barham, M.S. Lennard & G.T. Tucker. (1994) An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: Relevance to its use as a model of the CYP2d6 poor metaboliser phenotype. Biochemical Pharmacology 47:8, pages 1295-1307.
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G. Muralidharan, E. M. Hawes, G. McKay, E. D. Korchinski & K. K. Midha. (1991) Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase. European Journal of Clinical Pharmacology 41:5, pages 471-474.
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