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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 3
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Research Article

Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: inhibition in vitro and time course of induction in vivo

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Pages 255-267 | Received 15 Jan 1988, Accepted 01 Oct 1988, Published online: 22 Sep 2008

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Buket Alpertunga, Mehtap Kara, Mahmoud Abudayyak, Ezgi Oztas, Sibel Ozden & Gül Özhan. (2014) Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro. Toxicology Mechanisms and Methods 24:4, pages 268-275.
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Kevin Dowling, Colin Seymour & Carmel Mothersill. (2005) Delayed cell death and bystander effects in the progeny of Chinook Salmon Embryo cells exposed to radiation and a range of aquatic pollutants. International Journal of Radiation Biology 81:1, pages 89-96.
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K. Chalvet-monfray, P. Auger, L.P. Belzunces, C. Fleche & P. Sabatier. (1996) Synergy Between Deltamethrin and Prochloraz in Bees: Different Mechanisms of Action Tested by Modeling. SAR and QSAR in Environmental Research 5:3, pages 185-211.
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Articles from other publishers (33)

Elisa Pal, Hanine Almasri, Laurianne Paris, Marie Diogon, Maryline Pioz, Marianne Cousin, Déborah Sené, Sylvie Tchamitchian, Daiana Tavares, Frédéric Delbac, Nicolas Blot, Jean-Luc Brunet & Luc Belzunces. (2022) Toxicity of the Pesticides Imidacloprid, Difenoconazole and Glyphosate Alone and in Binary and Ternary Mixtures to Winter Honey Bees: Effects on Survival and Antioxidative Defenses. Toxics 10:3, pages 104.
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Katia Pes, Juan B. Ortiz-Delgado, Carmen Sarasquete, Vincent Laizé & Ignacio Fernández. (2022) Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment. Environmental Toxicology and Pharmacology 90, pages 103822.
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Nadiia Mosiichuk, Viktor Husak, Kenneth B. Storey & Volodymyr Lushchak. (2021) Acute Exposure to the Penconazole-Containing Fungicide Topas Induces Metabolic Stress in Goldfish. Chemical Research in Toxicology 34:12, pages 2441-2449.
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Michele Gottardi & Nina Cedergreen. (2019) The synergistic potential of azole fungicides does not directly correlate to the inhibition of cytochrome P450 activity in aquatic invertebrates. Aquatic Toxicology 207, pages 187-196.
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Michele Gottardi, Jonathan D. Tyzack, Andreas Bender & Nina Cedergreen. (2018) Can the inhibition of cytochrome P450 in aquatic invertebrates due to azole fungicides be estimated with in silico and in vitro models and extrapolated between species?. Aquatic Toxicology 201, pages 11-20.
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Andrea Rösch, Michele Gottardi, Caroline Vignet, Nina Cedergreen & Juliane Hollender. (2017) Mechanistic Understanding of the Synergistic Potential of Azole Fungicides in the Aquatic Invertebrate Gammarus pulex . Environmental Science & Technology 51:21, pages 12784-12795.
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Michele Gottardi, Michala Rosa Birch, Kristoffer Dalhoff & Nina Cedergreen. (2017) The effects of epoxiconazole and α-cypermethrin on Daphnia magna growth, reproduction, and offspring size . Environmental Toxicology and Chemistry 36:8, pages 2155-2166.
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Kristoffer Dalhoff, Michele Gottardi, Andreas Kretschmann & Nina Cedergreen. (2016) What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?. Aquatic Toxicology 172, pages 95-102.
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Nina Cedergreen. (2014) Quantifying Synergy: A Systematic Review of Mixture Toxicity Studies within Environmental Toxicology. PLoS ONE 9:5, pages e96580.
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Viktoriia Burkina, Vladimir Zlabek & Galia Zamaratskaia. (2013) Clotrimazole, but not dexamethasone, is a potent in vitro inhibitor of cytochrome P450 isoforms CYP1A and CYP3A in rainbow trout. Chemosphere 92:9, pages 1099-1104.
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Inês Domingues, Rhaul Oliveira, Carolina Musso, Marco Cardoso, Amadeu M.V.M. Soares & Susana Loureiro. (2011) Prochloraz effects on biomarkers activity in zebrafish early life stages and adults. Environmental Toxicology 28:3, pages 155-163.
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Luc P. Belzunces, Sylvie Tchamitchian & Jean-Luc Brunet. (2012) Neural effects of insecticides in the honey bee. Apidologie 43:3, pages 348-370.
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Daniel L. Villeneuve, Gerald T. Ankley, Elizabeth A. Makynen, Lindsey S. Blake, Katie J. Greene, Eric B. Higley, John L. Newsted, John P. Giesy & Markus Hecker. (2007) Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals. Ecotoxicology and Environmental Safety 68:1, pages 20-32.
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K. Knauer, C. Lampert & J. Gonzalez-Valero. (2007) Comparison of in vitro and in vivo acute fish toxicity in relation to toxicant mode of action. Chemosphere 68:8, pages 1435-1441.
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Leah D. Stuchal, Kevin M. Kleinow, John J. Stegeman & Margaret O. James. (2006) DEMETHYLATION OF THE PESTICIDE METHOXYCHLOR IN LIVER AND INTESTINE FROM UNTREATED, METHOXYCHLOR-TREATED, AND 3-METHYLCHOLANTHRENE-TREATED CHANNEL CATFISH ( ICTALURUS PUNCTATUS ): EVIDENCE FOR ROLES OF CYP1 AND CYP3A FAMILY ISOZYMES . Drug Metabolism and Disposition 34:6, pages 932-938.
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José María Navas, Antonio Chana, Bernardo Herradón & Helmut Segner. (2009) Induction of CYP1A by the N ‐imidazole derivative, 1‐benzylimidazole . Environmental Toxicology and Chemistry 22:4, pages 830-836.
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L. Debrauwer, E. Rathahao, G. Boudry, M. Baradat & J. P. Cravedi. (2001) Identification of the Major Metabolites of Prochloraz in Rainbow Trout by Liquid Chromatography and Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry 49:8, pages 3821-3826.
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Kevin Dowling & Carmel Mothersill. (2001) The further development of rainbow trout primary epithelial cell cultures as a diagnostic tool in ecotoxicology risk assessment. Aquatic Toxicology 53:3-4, pages 279-289.
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A Sturm, J.P Cravedi, E Perdu, M Baradat & H Segner. (2001) Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: a comparative in vitro/in vivo-assessment using cultured hepatocytes. Aquatic Toxicology 53:3-4, pages 229-245.
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A Sturm, J.P Cravedi & H Segner. (2001) Prochloraz and nonylphenol diethoxylate inhibit an mdr1-like activity in vitro, but do not alter hepatic levels of P-glycoprotein in trout exposed in vivo. Aquatic Toxicology 53:3-4, pages 215-228.
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J.P Cravedi, G Boudry, M Baradat, D Rao & L Debrauwer. (2001) Metabolic fate of 2,4-dichloroaniline, prochloraz and nonylphenol diethoxylate in rainbow trout: a comparative in vivo/in vitro approach. Aquatic Toxicology 53:3-4, pages 159-172.
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Chrisovalantis Papaefthimiou & George Theophilidis. (2001) The Cardiotoxic Action of the Pyrethroid Insecticide Deltamethrin, the Azole Fungicide Prochloraz, and Their Synergy on the Semi-Isolated Heart of the Bee Apis mellifera macedonica. Pesticide Biochemistry and Physiology 69:2, pages 77-91.
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S. Tar?s, J.-B. Berg?M. Amichot. (2000) Cloning and Expression of Cytochrome P450 Genes Belonging to the CYP4 Family and to a Novel Family, CYP48, in Two Hymenopteran Insects, Trichogramma cac?ciae and Apis mellifera. Biochemical and Biophysical Research Communications 268:3, pages 677-682.
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Steven L. Levine, James T. Oris & Michael S. Denison. (1999) Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propiconazole. Environmental Toxicology and Chemistry 18:11, pages 2565-2573.
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Steven L Levine & James T Oris. (1999) Noncompetitive mixed-type inhibition of rainbow trout CYP1A catalytic activity by clotrimazole. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 122:2, pages 205-210.
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Maggy Meled, Andreas Thrasyvoulou & Luc P. Belzunces. (1998) Seasonal variations in susceptibility of Apis mellifera to the synergistic action of prochloraz and deltamethrin . Environmental Toxicology and Chemistry 17:12, pages 2517-2520.
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R?my Vandame & Luc P Belzunces. (1998) Joint actions of deltamethrin and azole fungicides on honey bee thermoregulation. Neuroscience Letters 251:1, pages 57-60.
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Steven L. Levine, Hillary Czosnyka & James T. Oris. (2009) Effect of the fungicide clotrimazole on the bioconcentration of benzo[ a ]pyrene in gizzard shad ( Dorosoma cepedianum ): In vivo and in vitro inhibition of cytochrome P4501A activity . Environmental Toxicology and Chemistry 16:2, pages 306-311.
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Karine Chalvet‐Monfray, Philippe Sabatier, Luc P. Belzunces, Marc E. Colin & Cécile Fléché. (2009) Synergy between deltamethrin and prochloraz in bees: Modeling approach. Environmental Toxicology and Chemistry 15:4, pages 525-534.
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Margaret O. James. 1994. Pesticides in Ground and Surface Water. Pesticides in Ground and Surface Water 153 189 .
Gilles Monod, Am?lie De Mones & Alexis Fostier. (1993) Inhibition of ovarian microsomal aromatase and follicular oestradiol secretion by imidazole fungicides in Rainbow trout. Marine Environmental Research 35:1-2, pages 153-157.
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Marc‐Edouard Colin & Luc P. Belzunces. (2006) Evidence of synergy between prochloraz and deltamethrin in apis mellifera L.: a convenient biological approach . Pesticide Science 36:2, pages 115-119.
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Jacques Snegaroff & Jocelyne Bach. (1990) The effects of temperature on the basal activity of cytochrome P-450 in rainbow trout (Salmo gairdneri). Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 95:3, pages 515-519.
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