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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 3
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Research Article

A New Method for the Measurement of Nitrosoureas in Plasma: an H.P.L.C. Procedure for the Measurement of Fotemustine Kinetics

B. H. Gordon Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
R. P. Richards Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
M. P. Hiley Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
A. J. Gray Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
,
R. M. J. Ings Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
&
D. B. Campbell Servier Research and Development Ltd., Fulmer Hall, Windmill Road, Fulmer, Slough, SL3 6HH, UK
Pages 329-339 | Received 06 Sep 1988, Accepted 10 Nov 1988, Published online: 22 Sep 2008

Citations (17)

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Gaëlle Quéreux & Brigitte Dréno. (2011) Fotemustine for the treatment of melanoma. Expert Opinion on Pharmacotherapy 12:18, pages 2891-2904.
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David Khayat, Bruno Giroux, Jocelyne Berille, Véronique Cour, Béatrice Gerard, Marlis Sarkany, Philippe Bertrand & Jean-Pierre Bizzari. (1994) Fotemustine in the Treatment of Brain Primary Tumors and Metastases. Cancer Investigation 12:4, pages 414-420.
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A. Lemoine, C. Lucas & R. M. J. Ings. (1991) Metabolism of the chloroethylnitrosoureas. Xenobiotica 21:6, pages 775-791.
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I. Bartosek, M. Corada, S. Dallarda, C. Lucas, P. Deloffre & A. Guaitani. (1991) Pharmacokinetic profile of fotemustine in rat plasma by electrochemical detection. Xenobiotica 21:2, pages 235-242.
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Articles from other publishers (13)

Lijiao Zhao, Lili Li, Jie Xu & Rugang Zhong. (2014) Comparative investigation of the DNA inter-strand crosslinks induced by ACNU, BCNU, CCNU and FTMS using high-performance liquid chromatography?electrospray ionization tandem mass spectrometry. International Journal of Mass Spectrometry 368, pages 30-36.
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Susanne Nussbaumer, Pascal Bonnabry, Jean-Luc Veuthey & Sandrine Fleury-Souverain. (2011) Analysis of anticancer drugs: A review. Talanta 85:5, pages 2265-2289.
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Celeste Lindley, Thomas Shea, Jeannine McCune, Stacy Shord, Jodi Decker, Donald Harvey, William P. Petros, Don Garbriel, Jonathan Serody, Suzanne Kirby & Joseph Wiley. (2004) Intraindividual variability in busulfan pharmacokinetics in patients undergoing a bone marrow transplant: assessment of a test dose and first dose strategy. Anti-Cancer Drugs 15:5, pages 453-459.
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C. Dumontet, J. Jaubert, C. Sebban, F. Bouafia, C. Ardiet, B. Tranchand, E. Berger, C. Lucas, D. Guyotat & B. Coiffier. (2003) Clinical and pharmacokinetic phase II study of fotemustine in refractory and relapsing multiple myeloma patients. Annals of Oncology 14:4, pages 615-622.
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T Dine, F Khalfi, B Gressier, M Luyckx, C Brunet, L Ballester, F Goudaliez, J Kablan, M Cazin & J.C Cazin. (1998) Stability study of fotemustine in PVC infusion bags and sets under various conditions using a stability-indicating high-performance liquid chromatographic assay. Journal of Pharmaceutical and Biomedical Analysis 18:3, pages 373-381.
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J.T Hartmann, E Schmoll, C Bokemeyer, R Fety, C Lucas, B Giroux & H.-J Schmoll. (1998) Phase I pharmacological study of intra-arterially infused fotemustine for colorectal liver metastases. European Journal of Cancer 34:1, pages 87-91.
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A. Iliadis, M.-C. Launay-Iliadis, C. Lucas, R. Fety, F. Lokiec, B. Tranchand & G. Milano. (1996) Pharmacokinetics and pharmacodynamics of nitrosourea fotemustine: A French cancer centre multicentric study. European Journal of Cancer 32:3, pages 455-460.
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J.G. Supko, L.R. Phillips & L. Malspeis. (1996) Specific high-performance liquid chromatographic assay with ultraviolet detection for the determination of 1-(2-chloroethyl)-3-sarcosinamide-1-nitrosourea in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 677:2, pages 351-362.
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A. Le Cesne, G. Chabot, J. B?rille, C. Lucas, M. Baud, A. Gouyette, M. Marty & T. Le Chevalier. (1995) Phase I?II and pharmacokinetic study of a new fotemustine schedule in advanced non-small cell lung cancer. Lung Cancer 13:1, pages 69-78.
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Philippe Rougier, Guy G. Chabot, Jacques Bonneterre, Jean-Marie Tigaud, Catherine Lucas, Mariette Baud, Jocelyne B?rille & Alain Gouyette. (1993) Phase II and pharmacokinetic study of fotemustine in inoperable colorectal cancer. European Journal of Cancer 29:2, pages 288-289.
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B. Tranchand, C. Lucas, P. Biron, B. Giroux, B. Gordon, R. Richards, P. Solere, N. Roux, E. Evene, F. Mornex, M. Clavel & C. Ardiet. (1993) Phase I pharmacokinetics study of high-dose fotemustine and its metabolite 2-chloroethanol in patients with high-grade gliomas. Cancer Chemotherapy and Pharmacology 32:1, pages 46-52.
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R. Fety, C. Lucas, P. Solere, V. Cour & J. Vignoud. (1992) Hepatic intra-arterial infusion of fotemustine: pharmacokinetics. Cancer Chemotherapy and Pharmacology 31:2, pages 118-122.
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R.M.J. Ings, A.J. Gray, A.R. Taylor, B.H. Gordon, M. Breen, M. Hiley, R. Brownsill, N. Marchant, R. Richards, D. Wallace, T. Hughes, R. Thomas, J. Williams, C. Lucas & D.B. Campbell. (1990) Disposition, pharmacokinetics, and metabolism of 14C-fotemustine in cancer patients. European Journal of Cancer and Clinical Oncology 26:7, pages 838-842.
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