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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 4
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Research Article

Studies on the Biotransformation of Lonazolac, Bromerguride, Lisuride and Terguride in Laboratory Animals and their Hepatocytes

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Pages 361-377 | Received 27 Mar 1988, Accepted 01 Nov 1988, Published online: 22 Sep 2008

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José A G Agúndez, Elena García-Martín, Hortensia Alonso-Navarro & Félix Javier Jiménez-Jiménez. (2013) Anti-Parkinson's disease drugs and pharmacogenetic considerations. Expert Opinion on Drug Metabolism & Toxicology 9:7, pages 859-874.
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D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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K. Lavrijsen, J. Van Houdt, D. Van Dyck, J. Hendrickx, M. Bockx, R. Hurkmans, W. Meuldermans, L. Le Jeune, W. Lauwers & J. Heykants. (1992) Comparative metabolism of flunarizine in rats, dogs and man: an in vitro study with subcellular liver fractions and isolated hepatocytes. Xenobiotica 22:7, pages 815-836.
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Wolfram Engst, Ulrike Pabel & Hansruedi Glatt. (2002) Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases. Environmental Toxicology and Pharmacology 11:3-4, pages 243-250.
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Martin K. Bayliss & David M. Cross. 2000. The Hepatocyte Review. The Hepatocyte Review 365 389 .
H. Gieschen & M. Hildebrand. 1998. Forschung ohne Tierversuche 1997. Forschung ohne Tierversuche 1997 47 53 .
Reimund Rauschenbach, Hille Gieschen, Birgit Salomon, Christian Kraus, Gerhard Kühne & Michael Hildebrand. (1997) Development of a V79 cell line expressing human cytochrome P450 2D6 and its application as a metabolic screening tool. Environmental Toxicology and Pharmacology 3:1, pages 31-39.
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R. Gebhardt, H. Wegner & J. Alber. (1996) Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro. Cell Biology and Toxicology 12:2, pages 57-68.
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Reimund Rauschenbach, Hille Gieschen, Manfred Husemann, Birgit Salomon & Michael Hildebrand. (1995) Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives. European Journal of Pharmacology: Environmental Toxicology and Pharmacology 293:3, pages 183-190.
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Rolf Gebhardt. 1994. Alternatives to Animal Testing. Alternatives to Animal Testing 141 146 .
M. Hildebrand, M. Hümpel, H. Gieschen & C. Kraus. 1994. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research 1 19 .
Michael N. Berry, Heather J. Halls & Marlene B. Grivell. (1992) Techniques for pharmacological and toxicological studies with isolated hepatocyte suspensions. Life Sciences 51:1, pages 1-16.
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L. Qi-Gui, Z. Ming-Da & M. Hümpel. (1991) Investigations on the in vitro metabolism of five synthetic 19-norprogestins using hepatocyte suspensions isolated from five laboratory animal species. European Journal of Drug Metabolism and Pharmacokinetics 16:2, pages 93-102.
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. 1991. Isolated Hepatocytes Preparation, Properties and Applications. Isolated Hepatocytes Preparation, Properties and Applications 409 439 .
Gabriel A. Kyerematen, Monica Morgan, Genevieve Warner, Louis F. Martin & Elliot S. Vesell. (1990) Metabolism of nicotine by hepatocytes. Biochemical Pharmacology 40:8, pages 1747-1756.
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