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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 5
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Research Article

Formation of Ortho-Phenylphenol Glutathione Conjugates in the Rat Liver

Yoshio Naka Gawa Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo, 169, Japan
&
Sumiko Tayama Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo, 169, Japan
Pages 499-507 | Received 16 Aug 1988, Accepted 10 Jan 1989, Published online: 22 Sep 2008

Citations (13)

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E.M. Bomhard, S.Y. Brendler-Schwaab, A. Freyberger, B.A. Herbold, K.H. Leser & M. Richter. (2002) O-Phenylphenol and its Sodium and Potassium Salts: A Toxicological Assessment. Critical Reviews in Toxicology 32:6, pages 551-626.
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J. P. CRAVEDI, A. LAFUENTE, M. BARADAT, A. HILLENWECK & E. PERDU-DURAND. (1999) Biotransformation of pentachlorophenol, aniline and biphenyl in isolated rainbow trout (Oncorhynchus mykiss) hepatocytes: comparison with in vivo metabolism. Xenobiotica 29:5, pages 499-509.
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M. J. Ackland. (1993) Correlation between site specificity and electrophilic frontier values in the metabolic hydroxylation of biphenyl, di-aromatic and CYP2D6 substrates: a molecular modelling study. Xenobiotica 23:10, pages 1135-1144.
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Y. Nakagawa, S. Tayama, G. Moore & P. Moldéus. (1993) Effects of diethyl maleate on phenyl-hydroquinone-induced cytotoxicity in isolated rat hepatocytes. Xenobiotica 23:2, pages 205-213.
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Articles from other publishers (9)

Winfried A. Suske, Martin Held, Andreas Schmid, Thomas Fleischmann, Marcel G. Wubbolts & Hans-Peter E. Kohler. (1997) Purification and Characterization of 2-Hydroxybiphenyl 3-Monooxygenase, a Novel NADH-dependent, FAD-containing Aromatic Hydroxylase from Pseudomonas azelaica HBP1. Journal of Biological Chemistry 272:39, pages 24257-24265.
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Yoshio Nakagawa & Sumiko Tayama. (1996) Induction of 8-hydroxy-2′-deoxyguanosine in CHO-K1 cells exposed to phenyl-hydroquinone, a metabolite of ortho-phenylphenol. Cancer Letters 101:2, pages 227-232.
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Sumiko Tayama & Yoshio Nakagawa. (1994) Effect of scavengers of active oxygen species on cell damage caused in CHO-K1 cells by phenylhydroquinone, an o-phenylphenol metabolite. Mutation Research Letters 324:3, pages 121-131.
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David A. Eastmond. (1993) Induction of micronuclei and aneuploidy by the quinone-forming agents benzene and o-phenylphenol. Toxicology Letters 67:1-3, pages 105-118.
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Nakagawa Yoshio, Tayama Sumiko, Gregory Moore & Peter Moldéus. (1993) Cytotoxic effects of biphenyl and hydroxybiphenyls on isolated rat hepatocytes. Biochemical Pharmacology 45:10, pages 1959-1965.
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Nakagawa Yoshio & Peter Moldéust. (1992) Cytotoxic effects of phenyl-hydroquinone and some hydroquinones on isolated rat hepatocytes. Biochemical Pharmacology 44:6, pages 1059-1065.
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Yoshio Nakagawa, Sumiko Tayama, Gregory A. Moore & Peter Moldéus. (1992) Relationship between metabolism and cytotoxicity of ortho-phenylphenol in isolated rat hepatocytes. Biochemical Pharmacology 43:7, pages 1431-1437.
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Nakagawa Yoshio, Peter Moldéus & Gregory A. Moore. (1992) Cytotoxicity of orthro-phenylphenol in isolated rat hepatocytes. Biochemical Pharmacology 43:2, pages 159-165.
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Sumiko Tayama & Yoshio Nakagawa. (1991) Sulfhydryl compounds inhibit the cyto- and geno-toxicity of o-phenylphenol metabolites in CHO-K1 cells. Mutation Research/Genetic Toxicology 259:1, pages 1-12.
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