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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 5
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Research Article

The Measurement of D-Fenfluramine and Its Metabolite, D-Norfenfluramine in Plasma and Urine with an Application of the Method to Pharmacokinetic Studies

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Pages 547-553 | Received 15 Jan 1987, Published online: 22 Sep 2008

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Vincent Setola & Bryan L Roth. (2005) Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on ‘fen–phen’. Expert Opinion on Drug Metabolism & Toxicology 1:3, pages 377-387.
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Amal Kaddoumi, Mihoko N. Nakashima, Mitsuhiro Wada, Naotaka Kuroda, Yuji Nakahara & Kenichiro Nakashima. (2001) HPLC OF (±)-FENFLURAMINE AND PHENTERMINE IN PLASMA AFTER DERIVATIZATION WITH DANSYL CHLORIDE. Journal of Liquid Chromatography & Related Technologies 24:1, pages 57-67.
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Articles from other publishers (35)

M. Bernik, R.T. Ramos, L.A.B. Hetem & F. Graeff. (2019) Effect of single doses of pindolol and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients. Behavioural Brain Research 357-358, pages 82-87.
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Robin J. Tyacke & David J. Nutt. (2015) Optimising PET approaches to measuring 5-HT release in human brain. Synapse 69:10, pages 505-511.
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Donald G. Barceloux. 2012. Medical Toxicology of Drug Abuse. Medical Toxicology of Drug Abuse 255 274 .
Richard W. Foltin. (2011) Consumption of palatable food decreases the anorectic effects of serotonergic, but not dopaminergic drugs in baboons. Physiology & Behavior 103:5, pages 493-500.
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Amal Kaddoumi, Mitsuhiro Wada, Mihoko N. Nakashima & Kenichiro Nakashima. (2004) Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion. Forensic Science International 146:1, pages 39-46.
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Eric Doucet, Sylvie St-Pierre, Natalie Alméras & Angelo Tremblay. (2003) Relation between appetite ratings before and after a standard meal and estimates of daily energy intake in obese and reduced obese individuals. Appetite 40:2, pages 137-143.
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Amal Kaddoumi, Mihoko N Nakashima & Kenichiro Nakashima. (2001) Fluorometric determination of dl-fenfluramine, dl-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 763:1-2, pages 79-90.
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Amal Kaddoumi, Ai Kubota, Mihoko N. Nakashima, Masakatsu Takahashi & Kenichiro Nakashima. (2001) High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4‐(4,5‐diphenyl‐1 H ‐imidazole‐2‐yl)benzoyl chloride as a label . Biomedical Chromatography 15:6, pages 379-388.
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Akira Namera, Mikio Yashiki, Junting Liu, Kazuo Okajima, Kenji Hara, Tohru Imamura & Tohru Kojima. (2000) Simple and simultaneous analysis of fenfluramine, amphetamine and methamphetamine in whole blood by gas chromatography–mass spectrometry after headspace–solid phase microextraction and derivatization. Forensic Science International 109:3, pages 215-223.
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Fabrice Duval, Marie-Claude Mokrani, Paul Bailey, Humberto Correa, Than-Son Diep, Marc-Antoine Crocq & Jean-Paul Macher. (1999) Thyroid axis activity and serotonin function in major depressive episode. Psychoneuroendocrinology 24:7, pages 695-712.
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James D Christensen, Deborah A Yurgelun-Todd, Suzann M Babb, Staci A Gruber, Bruce M Cohen & Perry F Renshaw. (1999) Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy. Brain Research 834:1-2, pages 1-5.
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Bernabas Desta, Scott Steed, Denis Ravel, Nicole Laudignon, Paul M Vanhoutte & Chantal M Boulanger. (1998) Acute and Chronic Effects of Dexfenfluramine on the Porcine Pulmonary Artery. General Pharmacology: The Vascular System 30:3, pages 403-410.
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James D. Christensen, Suzann M. Babb, Bruce M. Cohen & Perry F. Renshaw. (2005) Quantitation of dexfenflurainine/d‐norfenfluramine concentration in primate brain using 19 F NMR spectroscopy . Magnetic Resonance in Medicine 39:1, pages 149-154.
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S. Rose, J. G. Hindmarsh, P. Collins & P. Jenner. (1997) The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. Journal of Neural Transmission 104:11-12, pages 1339-1351.
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Krishna P Datla & Gerald Curzon. (1997) The effect of d-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats. European Journal of Pharmacology 333:1, pages 27-31.
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Victoria S Haritos, Michael S Ching, Hany Ghabrial & Jorma T Ahokas. (1997) Measurement of dexfenfluramine metabolism in rat liver microsomes by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 693:2, pages 327-336.
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Peter Clausing, Larry G. Rushing, Glenn D. Newport & John F. Bowyer. (1997) Determination of d-fenfluramine, d-norfenfluramine and fluoxetine in plasma, brain tissue and brain microdialysate using high-performance liquid chromatography after precolumn derivatization with dansyl chloride. Journal of Chromatography B: Biomedical Sciences and Applications 692:2, pages 419-426.
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S. B. G. Park, D. J. Williamson & P. J. Cowen. (2009) 5-HT neuroendocrine function in major depression: prolactin and cortisol responses to D-fenfluramine. Psychological Medicine 26:6, pages 1191-1196.
Crossref
Thomas H. Schürmeyer, Götz Brademann & Alexander von zur Mühlen. (2006) Effect of fenfluramine on episodic ACTH and cortisol secretion. Clinical Endocrinology 45:1, pages 39-45.
Crossref
Robert J. Handa, Magdelena George, Ben H. Gordon, D.Bruce Campbell & Stanley A. Lorens. (1996) Responses to novelty stress in female F344 rats: Effects of age and d-fenfluramine treatment. Pharmacology Biochemistry and Behavior 53:3, pages 641-647.
Crossref
Nicholas J. Delva, David R. Matthews & Philip J. Cowen. (1996) Brain serotonin (5-HT) neuroendocrine function in patients taking cholesterol-lowering drugs. Biological Psychiatry 39:2, pages 100-106.
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D. J. Williamson, S. F. B. McTavish, S. B. G. Park & P. J. Cowen. (2018) Effect of Valine on 5-HT-mediated Prolactin Release in Healthy Volunteers, and on Mood in Remitted Depressed Patients. British Journal of Psychiatry 167:2, pages 238-242.
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M. Franklin, P.J. Cowen & R.D. Craven. (2016) The effects of a low tryptophan diet on brain 5 -HT metabolism and 5-HT-mediated neuroendocrine responses in the male rat. Journal of Psychopharmacology 9:4, pages 336-341.
Crossref
S. B. G. Park & P. J. Cowen. (1995) Effect of pindolol on the prolactin response tod-denfluramine. Psychopharmacology 118:4, pages 471-474.
Crossref
A.E.S. Walsh, A.D. Oldman, M. Franklin, C.G. Fairburn & P.J. Cowen. (1995) Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in women but not men. Journal of Affective Disorders 33:2, pages 89-97.
Crossref
Neil E. Rowland. (1994) Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: Body weight and brain serotonin changes. Pharmacology Biochemistry and Behavior 49:2, pages 287-294.
Crossref
Jia-ning Zeng, Lin Dou, Michael Duda & Hans H. Stuting. (1994) New chiral high-performance liquid chromatographic methodology used for the pharmacokinetic evaluation of dexfenfluramine. Journal of Chromatography B: Biomedical Sciences and Applications 654:2, pages 231-248.
Crossref
Ademola O. Oluyomi, Krishna P. Datla & Gerald Curzon. (1994) Effects of d-fenfluramine on feeding and hypothalamic 5-hydroxytryptamine and dopamine in male and female rats. European Journal of Pharmacology 255:1-3, pages 175-183.
Crossref
Annette S. Gross, Amanda C. Phillips, John Boutagy & Gillian M. Shenfield. (1993) Determination of dexfenfluramine and nordexfenfluramine in urine by high-performance liquid chromatography using ultraviolet detection. Journal of Chromatography B: Biomedical Sciences and Applications 621:1, pages 115-120.
Crossref
E. M. Goodall, P. J. Cowen, M. Franklin & T. Silverstone. (1993) Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers. Psychopharmacology 112:4, pages 461-466.
Crossref
Robert J. Handa, Molly K. Cross, Magdelena George, Ben H. Gordon, Lloyd H. Burgess, Theresa M. Cabrera, Norio Hata, D.Bruce Campbell & Stanley A. Lorens. (1993) Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: Effects of d-fenfluramine treatment. Pharmacology Biochemistry and Behavior 46:1, pages 101-109.
Crossref
J.P.H. Wilding, S.G. Gilbey, P.M. Jones, M.M. Mannan, M.A. Ghatei & S.R. Bloom. (1992) Dexfenfluramine treatment and hypothalamic neuropeptides in diet-induced obesity in rats. Peptides 13:3, pages 557-563.
Crossref
Errol B. De Souza, Robert Zaczek, Steven Culp, Nathan M. Appel & Joseph F. Contrera. (1991) Comparison of the effects of repeated oral versus subcutaneous fenfluramine administration on rat brain monoamine neurons: Pharmacokinetic and dose-response data. Pharmacology Biochemistry and Behavior 39:4, pages 963-969.
Crossref
J. ClancyJr.Jr., L.M. Petrovic, B.H. Gordon, R.J. Handa, D.B. Campbell & S.A. Lorens. (1991) Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female fischer 344 rats. International Journal of Immunopharmacology 13:8, pages 1203-1212.
Crossref
L. M. Petrovic, S. A. Lorens, M. George, T. Cabrera, B. H. Gordon, R. J. Handa, D. B. Campbell & J. Clancy. 1991. Serotonin: Molecular Biology, Receptors and Functional Effects. Serotonin: Molecular Biology, Receptors and Functional Effects 389 397 .

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