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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 9
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Research Article

Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat

Werner Lenk Walther Straub-Institut für Pharmakologie und Toxikologie der Universität München, D-8000, München 2, Nusbaumstr 26, FRG
,
Doris Löhr Walther Straub-Institut für Pharmakologie und Toxikologie der Universität München, D-8000, München 2, Nusbaumstr 26, FRG
&
Johann Sonnenbichler Max Planck-Institut für Biochemie, D-8033, Martinsried, Am Klopferspitz 18a, FRG
Pages 961-979 | Received 03 Sep 1988, Accepted 05 May 1989, Published online: 22 Sep 2008

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Courtney N. Jamison, Robert D. Dayton, Brian Latimer, Mary P. McKinney, Hannah G. Mitchell & Kenneth E. McMartin. (2021) Neurotoxic effects of nephrotoxic compound diethylene glycol. Clinical Toxicology 59:9, pages 810-821.
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Corie N. Robinson, Brian Latimer, Fleurette Abreo, Kiera Broussard & Kenneth E. McMartin. (2017) In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol. Clinical Toxicology 55:3, pages 196-205.
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Jeffrey A. Kraut. (2015) Diagnosis of toxic alcohols: limitations of present methods. Clinical Toxicology 53:7, pages 589-595.
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Leo J. Schep, Robin J. Slaughter, Wayne A. Temple & D. Michael G. Beasley. (2009) Diethylene glycol poisoning. Clinical Toxicology 47:6, pages 525-535.
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E. D. Booth, O. Dofferhoff, P. J. Boogaard & W. P. Watson. (2004) Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver. Xenobiotica 34:1, pages 31-48.
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Articles from other publishers (34)

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Kristi J. Reed, Dylan T. Freeman & Greg M. Landry. (2021) Diethylene glycol and its metabolites induce cell death in SH-SY5Y neuronal cells in vitro. Toxicology in Vitro 75, pages 105196.
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Miriam E. Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Thomas J. Flynn, Paddy L. Wiesenfeld & Robert L. Sprando. (2018) Diglycolic acid induces HepG2/C3A liver cell toxicity in vitro. Toxicology in Vitro 52, pages 87-93.
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Jeff Fowles, Marcy Banton, Joanna Klapacz & Hua Shen. (2017) A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action. Toxicology Letters 278, pages 66-83.
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William M. Snellings, Kenneth E. McMartin, Marcy I. Banton, Fred Reitman & Joanna Klapacz. (2017) Human health assessment for long-term oral ingestion of diethylene glycol. Regulatory Toxicology and Pharmacology 87, pages S1-S20.
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Miriam E. Mossoba, Sanah Vohra, Howard Toomer, Shelia Pugh-Bishop, Zachary Keltner, Vanessa Topping, Thomas Black, Nicholas Olejnik, Ana Depina, Kathleen Belgrave, Jessica Sprando, Joyce Njorge, Thomas J. Flynn, Paddy L. Wiesenfeld & Robert L. Sprando. (2017) Comparison of diglycolic acid exposure to human proximal tubule cells in vitro and rat kidneys in vivo. Toxicology Reports 4, pages 342-347.
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Loretta T Ford & Jonathan D Berg. (2015) Five-year review of a UK 24 hour testing service for plasma ethylene glycol and diethylene glycol. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 53:4, pages 459-465.
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Kelly W. Hall. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 419 444 .
Greg M. Landry, Cody L. Dunning, Fleurette Abreo, Brian Latimer, Elysse Orchard & Kenneth E. McMartin. (2015) Diethylene glycol-induced toxicities show marked threshold dose response in rats. Toxicology and Applied Pharmacology 282:3, pages 244-251.
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Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose & Makoto Hayashi. (2014) Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether. Regulatory Toxicology and Pharmacology 70:3, pages 711-719.
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Kalipatnapu Rao. 2012. Forensic Toxicology. Forensic Toxicology 211 246 .
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Greg M. Landry, Sarah Martin & Kenneth E. McMartin. (2011) Diglycolic Acid Is the Nephrotoxic Metabolite in Diethylene Glycol Poisoning Inducing Necrosis in Human Proximal Tubule Cells In Vitro. Toxicological Sciences 124:1, pages 35-44.
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Lauren M. Besenhofer, Marie C. McLaren, Brian Latimer, Michael Bartels, Mark J. Filary, Adam W. Perala & Kenneth E. McMartin. (2011) Role of Tissue Metabolite Accumulation in the Renal Toxicity of Diethylene Glycol. Toxicological Sciences 123:2, pages 374-383.
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Lauren M. Besenhofer, Patrick A. Adegboyega, Michael Bartels, Mark J. Filary, Adam W. Perala, Marie C. McLaren & Kenneth E. McMartin. (2010) Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats. Toxicological Sciences 117:1, pages 25-35.
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Xiaoping Xing, Xue Shi, Haitao Zhang, Weiyu Wang & Jiannong Ye. (2009) Determination of diethylene glycol in toothpaste by capillary electrophoresis with electrochemical detection. Microchimica Acta 167:3-4, pages 297-302.
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Josh Schier, Laura Conklin, Raquel Sabogal, Damon Dell’Aglio, Carlos Sanchez & James Sejvar. (2008) Medical toxicology and public health—Update on research and activities at the centers for disease control and prevention and the agency for toxic substances and disease registry. Journal of Medical Toxicology 4:1, pages 40-42.
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Bing-Liang Lin, Zhi-Xin Zhao, Yu-Tian Chong, Jian-Guo Li, Xing Zuo, Yu Tao, Tan-Qi Lou & Zhi-Liang Gao. (2008) Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China. World Journal of Gastroenterology 14:20, pages 3236.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Luis A. Ferrari & Leda Giannuzzi. (2005) Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol. Forensic Science International 153:1, pages 45-51.
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R. A. Corley, M. J. Bartels, E. W. Carney, K. K. Weitz, J. J. Soelberg, R. A. Gies & K. D. Thrall. (2005) Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans. Toxicological Sciences 85:1, pages 476-490.
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. (2004) NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of propylene glycol. Reproductive Toxicology 18:4, pages 533-579.
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Edward W. Carney, Ashley B. Liberacki, Michael J. Bartels & William J. Breslin. (1996) Identification of proximate toxicant for ethylene glycol developmental toxicity using rat whole embryo culture. Teratology 53:1, pages 38-46.
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Edward W. Carney. (1994) An integrated perspective on the developmental toxicity of ethylene glycol. Reproductive Toxicology 8:2, pages 99-113.
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R. Heilmair, W. Lenk & D. Löhr. (1993) Toxicokinetics of diethylene glycol (DEG) in the rat. Archives of Toxicology 67:10, pages 655-666.
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