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Xenobiotica

the fate of foreign compounds in biological systems

Volume 19, 1989 - Issue 9

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Research Article

Disposition of a new tetrahydrocarbazole analgesic drug in laboratory animals and man

J. A. Scatina Drug Metabolism Division, Wyeth-Ayerst Research, Inc., CN 8000 Princeton, New Jersey 08547-8000, USA

D. R. Hicks Drug Metabolism Division, Wyeth-Ayerst Research, Inc., CN 8000 Princeton, New Jersey 08547-8000, USA

M. Kraml Drug Metabolism Division, Wyeth-Ayerst Research, Inc., CN 8000 Princeton, New Jersey 08547-8000, USA

M. N. Cayen Drug Metabolism Division, Wyeth-Ayerst Research, Inc., CN 8000 Princeton, New Jersey 08547-8000, USA

Pages 991-1002 | Received 10 Oct 1988, Accepted 10 May 1989, Published online: 22 Sep 2008

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https://doi.org/10.3109/00498258909043156

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Dermot F. McGinnity & Ken Grime. 2023. The Handbook of Medicinal Chemistry. The Handbook of Medicinal Chemistry 298 323 .

Liqiang Su, Jiahui Li, Zhen Zhou, Dongxia Huang, Yuanjin Zhang, Haixiang Pei, Weikai Guo, Haigang Wu, Xin Wang, Mingyao Liu, Cai-Guang Yang & Yihua Chen. (2019) Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. European Journal of Medicinal Chemistry 162, pages 203-211.
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Sujay Ghosh, Amrit Krishna Mitra, Uttam Pal, Samita Basu & Chandan Saha. (2017) Evidence of two structurally related solvatochromic probes complexed with β-cyclodextrin by using spectroscopic methods. Journal of Molecular Structure 1130, pages 810-817.
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D.F. McGinnity & K. Grime. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 34 44 .

Kenneth H. Grime, Patrick Barton & Dermot F. McGinnity. (2013) Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics. Molecular Pharmaceutics 10:4, pages 1191-1206.
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Ken Grime & Stuart W. Paine. (2013) Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement. Drug Metabolism and Disposition 41:2, pages 372-378.
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Marilyn E. Morris, Xinning Yang, Yash A. Gandhi, Suraj G. Bhansali & Lisa J. Benincosa. (2012) Interspecies scaling: prediction of human biliary clearance and comparison with QSPKR. Biopharmaceutics & Drug Disposition 33:1, pages 1-14.
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Huadong Tang, Azher Hussain, Mauricio Leal, Eric Fluhler & Michael Mayersohn. (2011) Controversy in the Allometric Application of Fixed- Versus Varying-Exponent Models: A Statistical and Mathematical Perspective. Journal of Pharmaceutical Sciences 100:2, pages 402-410.
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Neal M. Davies, Jody K. Takemoto, Dion R. Brocks & Jaime A. Yáñez. (2010) Multiple Peaking Phenomena in Pharmacokinetic Disposition. Clinical Pharmacokinetics 49:6, pages 351-377.
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Iftekhar Mahmood. (2009) Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?. Journal of Pharmaceutical Sciences 98:7, pages 2472-2493.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Iftekhar Mahmood. (2005) Interspecies Scaling of Biliary Excreted Drugs: A Comparison of Several Methods**The views expressed in this article are those of the author and do not reflect the official policy of the FDA. No official support or endorsement by the FDA is intended or should be inferred.. Journal of Pharmaceutical Sciences 94:4, pages 883-892.
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Giuseppe Giannini, Mauro Marzi, Gian Piero Moretti, Sergio Penco, Maria Ornella Tinti, Silvia Pesci, Francesco Lazzaro & Francesco De Angelis. (2004) Synthesis of Cycloalkanoindoles by an Unusual DAST‐Triggered Rearrangement Reaction. European Journal of Organic Chemistry 2004:11, pages 2411-2420.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Iftekhar Mahmood & Chandra Sahajwalla. (2002) Interspecies scaling of biliary excreted drugs. Journal of Pharmaceutical Sciences 91:8, pages 1908-1914.
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Iftekhar Mahmood. (2002) Interspecies Scaling: Predicting Oral Clearance in Humans. American Journal of Therapeutics 9:1, pages 35-42.
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Disposition of a new tetrahydrocarbazole analgesic drug in laboratory animals and man

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Disposition of a new tetrahydrocarbazole analgesic drug in laboratory animals and man

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