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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 9
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Research Article

The degradation of haem by carbon tetrachloride: Metabolic activation requires a free axial coordination site on the haem iron and electron donation

M. Manno Biochemical Pharmacology Section, Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, SM5 4EF, UK
,
L. J. King Department of Biochemistry, University of Surrey, Guildford, Surrey, GU2 5XH, UK
&
F. De Matteis Biochemical Pharmacology Section, Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey, SM5 4EF, UK
Pages 1023-1035 | Received 28 Mar 1988, Accepted 15 Mar 1989, Published online: 22 Sep 2008

Citations (14)

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R. Tolando, R. Ferrara, N. I. Eldirdiri, A. Albores, L. J. King & M. Manno. (1996) Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450. Xenobiotica 26:4, pages 425-435.
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Arnold R. Goeptar, Heleen Scheerens & Nico P. E. Vermeulen. (1995) Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 25:1, pages 25-65.
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Articles from other publishers (12)

J. Fujimoto & Y. Iimuro. 2010. Comprehensive Toxicology. Comprehensive Toxicology 437 455 .
Enika NagababuJoseph M. Rifkind. (2004) Heme Degradation by Reactive Oxygen Species. Antioxidants & Redox Signaling 6:6, pages 967-978.
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Scott S. Billecke, Andrew T. Bender, Kimon C. Kanelakis, Patrick J.M. Murphy, Ezra R. Lowe, Yasuhiko Kamada, William B. Pratt & Yoichi Osawa. (2002) hsp90 Is Required for Heme Binding and Activation of Apo-Neuronal Nitric-oxide Synthase. Journal of Biological Chemistry 277:23, pages 20504-20509.
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Maurizio Manno, Roberto Tolando, Roberta Ferrara, Michela Rezzadore & Stefano Cazzaro. (1995) Suicidal inactivation of haemoproteins by reductive metabolites of halomethanes: a structure-activity relationship study. Toxicology 100:1-3, pages 175-183.
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Pei-Chun. Chiu & Martin. Reinhard. (2002) Metallocoenzyme-Mediated Reductive Transformation of Carbon Tetrachloride in Titanium(III) Citrate Aqueous Solution. Environmental Science & Technology 29:3, pages 595-603.
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Roberto Tolando, Stefano Cazzaro, Roberta Ferrara, Michela Rezzadore & Maurizio Manno. (1995) Reductive activation of halothane by human haemoglobin results in the modification of the prosthetic haem. Biochemical Pharmacology 49:2, pages 233-241.
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Howard D. Colby, Harold Purcell, Shiro Kominami, Shigeki Takemori & Kossor David C.. (1994) Adrenal activation of carbon tetrachloride: role of microsomal P450 isozymes. Toxicology 94:1-3, pages 31-40.
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Roberta Ferrara, Michela Rezzadore, Stefano Cazzaro, Roberto Tolando & Maurizio Manno. (2020) Reductive Activation of Carbon Tetrachloride by Human Haemoglobin. Alternatives to Laboratory Animals 21:1, pages 57-64.
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M. Manno, R. Ferrara, S. Cazzaro, P. Rigotti & E. Ancona. (2009) Suicidal Inactivation of Human Cytochrome P‐450 by Carbon Tetrachloride and Halothane in Vitro . Pharmacology & Toxicology 70:1, pages 13-18.
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Maurizio Manno, Stefano Cazzaro & Michela Rezzadore. (1991) The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane. Archives of Toxicology 65:3, pages 191-198.
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Maurizio Manno, Michela Rezzadore & Stefano Cazzaro. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 329 332 .
Paul R. Ortiz de Montellano. (1990) Free radical modification of prosthetic heme groups. Pharmacology & Therapeutics 48:1, pages 95-120.
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