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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

The use of porcine hepatocytes for biotransformation studies of veterinary drugs

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Pages 1207-1219 | Received 25 Sep 1988, Accepted 01 Jun 1989, Published online: 22 Sep 2008

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Jiin-Ju Guo, Hong-Nong Chou & I. Chiu Liao. (2003) Disposition of 3-(4-cyano-2-oxobutylidene amino)-2-oxazolidone, a cyano-metabolite of furazolidone, in furazolidone-treated grouper. Food Additives & Contaminants 20:3, pages 229-236.
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Koebe Hg, Mueller-Hoecker J, Koebe S & Schildberg Fw. (1995) Viable Porcine Hepatocytes from Slaughterhouse Organs. Artificial Cells, Blood Substitutes, and Biotechnology 23:5, pages 613-626.
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L. A. P. Hoogenboom, Th. H. G. Polman, A. Lommen, M. B. M. Huveneers & J. Van Rhijn. (1994) Biotransformation of furaltadone by pig hepatocytes and Salmonella typhimurium TA 100 bacteria, and the formation of protein-bound metabolites. Xenobiotica 24:8, pages 713-727.
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G. A. E. Van't Klooster, F. M. A. Woutersen-Van Nijnanten, B. J. Blaauboer, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1994) Applicability of cultured hepatocytes derived from goat, sheep and cattle in comparative drug metabolism studies. Xenobiotica 24:5, pages 417-428.
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G. A. E. Van ‘t Klooster, F. M. A. Woutersen-Van Nijnanten, W. R. Klein, B. J. Blaauboer, J. Noordhoek & A. S. J. P. A. M. Van Miert. (1992) Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies. Xenobiotica 22:5, pages 523-534.
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Articles from other publishers (25)

Martin Krøyer Rasmussen, Galia Zamaratskaia & Bo Ekstrand. (2014) Comparable constitutive expression and activity of cytochrome P450 between the lobes of the porcine liver. Toxicology in Vitro 28:7, pages 1190-1195.
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Michael Maringka, Shibashish Giri & Augustinus Bader. (2010) Preclinical characterization of primary porcine hepatocytes in a clinically relevant flat membrane bioreactor. Biomaterials 31:1, pages 156-172.
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Angelika Langsch, Shibashish Giri, Ali Acikgöz, Inka Jasmund, Bernd Frericks & Augustinus Bader. (2009) Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture. Toxicology Letters 188:3, pages 173-179.
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C. Montesissa, F. Capolongo, A. Santi, G. Biancotto & M. Dacasto. (2004) Metabolism of tilmicosin by rabbit liver microsomes and hepatocytes. The Veterinary Journal 167:1, pages 87-94.
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S.L. Abrahamse, M.-P. Van De Kerkhove, M.N. Sosef, R. Hartman, R.A.F.M. Chamuleau & T.M. Van Gulik. (2018) Treatment of Acute Liver Failure in Pigs Reduces Hepatocyte Function in a Bioartificial Liver Support System. The International Journal of Artificial Organs 25:10, pages 966-974.
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C Eeckhoutte, A Giuliano Albo, M Carletti, A Rossetto Giaccherino, P Galtier, C Nebbia & M Dacasto. (2002) Time-dependent variations of drug-metabolising enzyme activities (DMEs) in primary cultures of rabbit hepatocytes. Toxicology in Vitro 16:4, pages 375-382.
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Laurentius A.P Hoogenboom, Gerard D van Bruchem, Kim Sonne, Ilona C Enninga, Johannes A van Rhijn, Henri Heskamp, Margot B.M Huveneers-Oorsprong, Jan C.M van der Hoeven & Harry A Kuiper. (2002) Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone. Environmental Toxicology and Pharmacology 11:3-4, pages 273-287.
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Inka Jasmund & Augustinus Bader. 2002. Tools and Applications of Biochemical Engineering Science. Tools and Applications of Biochemical Engineering Science 99 109 .
Angelika Langsch & Augustinus Bader. (2001) Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors. Biotechnology and Bioengineering 76:2, pages 115-125.
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Martínez‐Larrañaga, Anadón, Fernandez‐Cruz, Díaz, Martinez, Frejo, Martínez & Tafur. (2008) Cytotoxicity in pig hepatocytes induced by 8‐quinolinol, chloramine‐T and natamycin. Journal of Veterinary Pharmacology and Therapeutics 23:1, pages 37-44.
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John M. Brameld, R. Stewart Gilmour & Peter J. Buttery. (1999) Glucose and Amino Acids Interact with Hormones to Control Expression of Insulin-Like Growth Factor-I and Growth Hormone Receptor mRNA in Cultured Pig Hepatocytes. The Journal of Nutrition 129:7, pages 1298-1306.
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M. Monshouwer, G.A.E. van't Klooster, S.M. Nijmeijer, R.F. Witkamp & A.S.J.P.A.M. van Miert. (1998) Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes. Toxicology in Vitro 12:6, pages 715-723.
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M.B.M. Huveneers-Oorsprong, L.A.P. Hoogenboom & H.A. Kuiper. (1997) The use of the MTT test for determining the cytotoxicity of veterinary drugs in pig hepatocytes. Toxicology in Vitro 11:4, pages 385-392.
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L.A.P. Hoogenboom & H.A. Kuiper. (1997) The use of in vitro models for assessing the presence and safety of residues of xenobiotics in food. Trends in Food Science & Technology 8:5, pages 157-166.
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Elisabeth G. Jensen, Rune Thauland & Nils E. Soli. (2020) Measurement of Xenobiotic Metabolising Enzyme Activities in Primary Monolayer Cultures of Immature Rainbow Trout Hepatocytes at Two Acclimatisation Temperatures. Alternatives to Laboratory Animals 24:5, pages 727-740.
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H.G. Koebe & F.W. Schildberg. (2018) Isolation of Porcine Hepatocytes from Slaughterhouse Organs. The International Journal of Artificial Organs 19:1, pages 53-60.
Crossref
C. Montesissa, P. Anfossi, G. Van't Klooster & M. Mengelers. (1996) The use of cultured hepatocytes from goats and cattle to investigate xenobiotic oxidative metabolism. Veterinary Research Communications 20:5, pages 449-460.
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Anje A te Velde, Nita C.J.J. Ladiges, Leonard M. Flendrig & Robert A.F.M. Chamuleau. (1995) Functional activity of isolated pig hepatocytes attached to different extracellular matrix substrates. Implication for application of pig hepatocytes in a bioartificial liver. Journal of Hepatology 23:2, pages 184-192.
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I. De Angelis, L.A.P. Hoogenboom, M.B.M. Huveneers-Oorsprong, F. Zucco & A. Stammati. (1994) Established cell lines for safety assessment of food contaminants: Differing furazolidone toxicity to V 79, HEp-2 and Caco-2 cells. Food and Chemical Toxicology 32:5, pages 481-488.
Crossref
C. Montesissa, M.B.M. Huveneers, L.A.P. Hoogenboom, M. Amorena, M. De Liguoro & A. Lucisano. (1994) THE OXIDATIVE METABOLISM OF ALDICARB IN PIGS: IN VIVO - IN VITRO COMPARISON. Drug Metabolism and Drug Interactions 11:2.
Crossref
G. A. E. VAN T KLOOSTER, B.J. BLAAUBOER, J‐ NOORDHOEK & A. S.J. P. A. M. VAN MIERT. (2008) Sulfadimidine metabolism in vitro: II. comparative studies in cultured rat, goat, sheep and cattle hepatocytes. Journal of Veterinary Pharmacology and Therapeutics 16:4, pages 454-461.
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L.A.P. Hoogenboom, M. van Kammen, M.B.M. Huveneers-Oorsprong & H.A. Kuiper. (1992) Study on the role of glutathione in the biotransformation and toxicity of furazolidone using pig hepatocytes. Toxicology in Vitro 6:3, pages 227-237.
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L.A.P. Hoogenboom, M.B.M. Oorsprong, T. van Vliet & H.A. Kuiper. (1991) The use of pig hepatocytes for cytotoxicity studies of veterinary drugs: A comparative study with furazolidone and other nitrofurans. Toxicology in Vitro 5:1, pages 31-38.
Crossref
L.A.P. Hoogenboom, M. van Kammen, M.C.J. Berghmans, J.H. Koeman & H.A. Kuiper. (1991) The use of pig hepatocytes to study the nature of protein-bound metabolites of furazolidone: a new analytical method for their detection. Food and Chemical Toxicology 29:5, pages 321-328.
Crossref
L.A.P. Hoogenboom, O. Tomassini, M.B.M. Oorsprong & H.A. Kuiper. (1991) Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone. Food and Chemical Toxicology 29:3, pages 185-191.
Crossref

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