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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans

A. N. Kotake Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
,
S. K. Kuwahara Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
,
E. Burton Department of Drug Metabolism, G. D. Searle & Co., 4901 Searle Parkway, Skokie, IL, 60077, USA
,
C. E. McCoy Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
&
L. I. Goldberg Committee on Clinical Pharmacology, Departments of Pharmacological and Physiological Sciences and Medicine, The University of Chicago, 947 East 58th Street, Chicago, IL, 60637, USA
Pages 1247-1254 | Received 24 Nov 1988, Accepted 04 May 1989, Published online: 22 Sep 2008

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Dan Zhang, Jing-Yi Ma, Man Yang, Ming Deng & Huichen Liu. (2018) Pharmacokinetic study of methylnaltrexone after single and multiple subcutaneous administrations in healthy Chinese subjects. Xenobiotica 48:8, pages 804-808.
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Wojciech Leppert. (2015) Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Design, Development and Therapy 9, pages 2215-2231.
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Sabine Bader, Thorsten Dürk & Gerhild Becker. (2013) Methylnaltrexone for the treatment of opioid-induced constipation. Expert Review of Gastroenterology & Hepatology 7:1, pages 13-26.
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Yakov Rotshteyn, Thomas A Boyd & Chun-Su Yuan. (2011) Methylnaltrexone bromide: research update of pharmacokinetics following parenteral administration. Expert Opinion on Drug Metabolism & Toxicology 7:2, pages 227-235.
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Katri Elina Clemens & Eberhard Klaschik. (2010) Managing opioid-induced constipation in advanced illness: focus on methylnaltrexone bromide. Therapeutics and Clinical Risk Management 6, pages 77-82.
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Michael D Kraft. (2008) Methylnaltrexone, a new peripherally acting mu-opioid receptor antagonist being evaluated for the treatment of postoperative ileus. Expert Opinion on Investigational Drugs 17:9, pages 1365-1377.
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Beverley Greenwood-Van Meerveld. (2007) Emerging drugs for postoperative ileus. Expert Opinion on Emerging Drugs 12:4, pages 619-626.
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Peter Holzer. (2007) Treatment of opioid-induced gut dysfunction. Expert Opinion on Investigational Drugs 16:2, pages 181-194.
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Chun-Su Yuan & Robert J Israel. (2006) Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects. Expert Opinion on Investigational Drugs 15:5, pages 541-552.
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Syed Z Ali & Andrea Kurz. (2004) Methylnaltrexone and alvimopan: economic management of opioid-induced bowel dysfunction. Expert Review of Pharmacoeconomics & Outcomes Research 4:2, pages 153-157.
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Articles from other publishers (42)

Sarah Jepkes, Marie Josee-Lemoy, Heather Knych, Thiago de Lucena, Amir Ardeshir & Diane E Stockinger. (2023) The Pharmacokinetics of Subcutaneous Methylnaltrexone Bromide in Rhesus Macaques ( Macaca mulatta ) . Journal of the American Association for Laboratory Animal Science 62:3, pages 260-266.
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Kim Juhani Blomqvist, Katarzyna Anna Dudek, Hanna Viisanen, Kert Mätlik, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Anneli Kalso, Pekka Veli Rauhala & Tuomas Olavi Lilius. (2020) Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats. Journal of Neuroscience Research 100:1, pages 329-338.
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Donald J. AbrahamChristopher R. McCurdy & Thomas E. Prisinzano. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 171 .
D. Matthew Walentiny, Essie Komla, Léa T. Moisa, Mohammed A. Mustafa, Justin L. Poklis, Hamid I. Akbarali & Patrick M. Beardsley. (2021) Methylnaltrexone crosses the blood-brain barrier and attenuates centrally-mediated behavioral effects of morphine and oxycodone in mice. Neuropharmacology 185, pages 108437.
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Essie Komla, David L. Stevens, Yi Zheng, Yan Zhang, William L. Dewey & Hamid I. Akbarali. (2019) Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine via Peripheral Opioid Receptors. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 504-513.
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T. Sobolevsky, Y. Kucherova & B. Ahrens. (2018) Identification of oxymorphone as decomposition product of the permitted drug methylnaltrexone. Drug Testing and Analysis 10:5, pages 892-895.
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Christina Jagla, Peter Martus & Christoph Stein. (2014) Peripheral opioid receptor blockade increases postoperative morphine demands—A randomized, double-blind, placebo-controlled trial. Pain 155:10, pages 2056-2062.
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Michael Schäfer. 2011. Anesthetic Pharmacology. Anesthetic Pharmacology 493 508 .
Scott R. Armstrong, Christina B. Campbell, Carrie L. Richardson, Ross G. Vickery, Pamela R. Tsuruda, Daniel D. Long, Sharath S. Hegde & David T. Beattie. (2013) The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity. Naunyn-Schmiedeberg's Archives of Pharmacology 386:6, pages 471-478.
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S. BaderK. JaroslawskiH.E. BlumG. Becker. (2011) Opioid-Induced Constipation in Advanced Illness: Safety and Efficacy of Methylnaltrexone Bromide. Clinical Medicine Insights: Oncology 5, pages CMO.S4867.
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Donald J. AbrahamChristopher R. McCurdy & Thomas E. Prisinzano. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 569 736 .
Appavu Chandrasekaran, Zeen Tong, Hongshan Li, John C. L. Erve, William DeMaio, Igor Goljer, Oliver McConnell, Yakov Rotshteyn, Theresa Hultin, Rasmy Talaat & JoAnn Scatina. (2010) Metabolism of Intravenous Methylnaltrexone in Mice, Rats, Dogs, and Humans. Drug Metabolism and Disposition 38:4, pages 606-616.
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Francisco M. Abarca, Theodore J. SaclaridesMarc I. Brand. (2010) A Review of the Treatment of Opioid-induced Constipation with Methylnaltrexone Bromide. Clinical Medicine Insights: Therapeutics 2, pages CMT.S1168.
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Chun-Su Yuan, Joseph F. Foss, Wade A. Williams & Jonathan Moss. (2009) Development and use of methylnaltrexone, a peripherally acting opioid antagonist, to treat side effects related to opioid use. Drug Development Research 70:6, pages 403-416.
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Eugene R. Viscusi, Tong J. Gan, John B. Leslie, Joseph F. Foss, Mark D. Talon, Wei Du & Gay Owens. (2009) Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability. Anesthesia & Analgesia 108:6, pages 1811-1822.
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Peter Holzer. (2009) Opioid receptors in the gastrointestinal tract. Regulatory Peptides 155:1-3, pages 11-17.
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Gerhild Becker & Hubert E Blum. (2009) Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus. The Lancet 373:9670, pages 1198-1206.
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David R. P. Guay. (2009) <b>Methylnaltrexone Methobromide: The First Peripherally Active, Centrally Inactive Opioid Receptor-Antagonist Clinical Review</b>. The Consultant Pharmacist 24:3, pages 210-226.
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Chun-Su Yuan & Robert J. Israel. 2009. Opiate Receptors and Antagonists. Opiate Receptors and Antagonists 175 198 .
Jonathan Moss & Carl E. Rosow. (2008) Development of Peripheral Opioid Antagonists: New Insights Into Opioid Effects. Mayo Clinic Proceedings 83:10, pages 1116-1130.
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Evan D. Kharasch. (2008) Mutations in a Molecule: The Virtues of Antagonism. Mayo Clinic Proceedings 83:10, pages 1083-1086.
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Peter Holzer. (2008) Methylnaltrexone for the management of unwanted peripheral opioid effects. Therapy 5:4, pages 531-543.
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Diane L. DeHaven-Hudkins, Robert N. DeHaven, Patrick J. Little & Lee M. Techner. (2008) The involvement of the μ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor. Pharmacology & Therapeutics 117:1, pages 162-187.
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Michael D. Kraft. (2007) Emerging pharmacologic options for treating postoperative ileus. American Journal of Health-System Pharmacy 64:20_Supplement_13, pages S13-S20.
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C E Rosow, P Gomery, T Y Chen, P Stefanovich, N Stambler & R Israel. (2007) Reversal of Opioid-Induced Bladder Dysfunction by Intravenous Naloxone and Methylnaltrexone. Clinical Pharmacology & Therapeutics 82:1, pages 48-53.
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D. T. Beattie, M. Cheruvu, N. Mai, M. O’Keefe, S. Johnson-Rabidoux, C. Peterson, E. Kaufman & R. Vickery. (2007) The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone. Naunyn-Schmiedeberg's Archives of Pharmacology 375:3, pages 205-220.
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Hiroyuki Fukuda, Kiyotaka Suenaga, Daisuke Tsuchida, Christopher R. Mantyh, Theodore N. Pappas, Gareth A. Hicks, Diane L. DeHaven-Hudkins & Toku Takahashi. (2006) The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats. Brain Research 1102:1, pages 63-70.
Crossref
B. Greenwood-Van Meerveld, C. J. Gardner, P. J. Little, G. A. Hicks & D. L. Dehaven-Hudkins. (2004) Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterology and Motility 16:s2, pages 46-53.
Crossref
Han H Aung, Sangeeta R Mehendale, Jing-Tian Xie, Jonathan Moss & Chun-Su Yuan. (2004) Methylnaltrexone prevents morphine-induced kaolin intake in the rat. Life Sciences 74:22, pages 2685-2691.
Crossref
John J. Bates, Joseph F. Foss & Damian B. Murphy. (2004) Are Peripheral Opioid Antagonists the Solution to Opioid Side Effects?. Anesthesia & Analgesia, pages 116-122.
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Brian Behm & Neil Stollman. (2003) Postoperative ileus: Etiologies and interventions. Clinical Gastroenterology and Hepatology 1:2, pages 71-80.
Crossref
Donald J. AbrahamJane V. Aldrich & Sandra C. Vigil‐Cruz. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 331 482 .
Andrea Kurz & Daniel I Sessler. (2003) Opioid-Induced Bowel Dysfunction. Drugs 63:7, pages 649-671.
Crossref
Youn Seon Choi & J.Andrew Billings. (2002) Opioid Antagonists. Journal of Pain and Symptom Management 24:1, pages 71-90.
Crossref
Joseph F Foss. (2001) A Review of the Potential Role of Methylnaltrexone in Opioid Bowel Dysfunction. The American Journal of Surgery 182:5, pages S19-S26.
Crossref
Chun-Su Yuan & Joseph F. Foss. (2000) Methylnaltrexone: Investigation of clinical applications. Drug Development Research 50:2, pages 133-141.
Crossref
Joseph F. Foss, Eric Orelind & Leon I. Goldberg. (1996) Effects of methylnaltrexone on morphine-induced cough suppression in guinea pigs. Life Sciences 59:15, pages PL235-PL238.
Crossref
Chun-Su Yuan, Joseph F. Foss, Michael O'Connor, Alicia Toledano, Michael F. Roizen & Jonathan Moss. (1996) Methylnaltrexone prevents morphine-induced delay in oral-cecal transit time without affecting analgesia: A double-blind randomized placebo-controlled trial*. Clinical Pharmacology & Therapeutics 59:4, pages 469-475.
Crossref
Joseph F. Foss, Alan S. Bass & Leon I. Goldberg. (2013) Dose‐Related Antagonism of the Emetic Effect of Morphine by Methylnaltrexone in Dogs. The Journal of Clinical Pharmacology 33:8, pages 747-751.
Crossref
A. B. L. Lanting, A. P. Bruins, B. F. H. Drenth, K. de Jonge, K. Ensing, R. A. de Zeeuw & D. K. F. Meijer. (1993) Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomersN-methyl dextrorphan andN-methyl levorphanol after rat liver perfusion. Biological Mass Spectrometry 22:4, pages 226-234.
Crossref
Andrew Barber & Rudolf Gottschlich. (1992) Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation. Medicinal Research Reviews 12:5, pages 525-562.
Crossref
K. W. Bentley. (1991) β-Phenylethylamines and the isoquinoline alkaloids. Nat. Prod. Rep. 8:4, pages 339-366.
Crossref

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