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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 11
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Research Article

Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics

M. Delaforge UA 400 CNRS, Université René Descartes, 45 Rue des Saints-Péres 75270, Paris, Cedex, 06, France
,
R. Rivière Service Hospitalier Frédéric Joliot, Département de Biologie, CEN-Saclay 91191, Gif-sur-Yvette, Cedex, France
,
E. Sartori UA 400 CNRS, Université René Descartes, 45 Rue des Saints-Péres 75270, Paris, Cedex, 06, France
,
J. L. Doignon Section de Pharmacologie et d'Immunologie, Département de Biologie, CEN-Saclay 91191, Gif-sur-Yvette, Cedex, France
&
J. M. Grognet Section de Pharmacologie et d'Immunologie, Département de Biologie, CEN-Saclay 91191, Gif-sur-Yvette, Cedex, France
Pages 1285-1295 | Received 13 Dec 1988, Accepted 04 May 1989, Published online: 22 Sep 2008

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Abigail L. Chua & Stephen Silberstein. (2016) Inhaled drug therapy development for the treatment of migraine. Expert Opinion on Pharmacotherapy 17:13, pages 1733-1743.
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C. Aninat, F. André & M. Delaforge. (2005) Oxidative metabolism by P450 and function coupling to efflux systems: Modulation of mycotoxin toxicity. Food Additives & Contaminants 22:4, pages 361-368.
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Dennis A. Smith. (1991) Species Differences in Metabolism and Pharmacokinetics: Are We Close to an Understanding?. Drug Metabolism Reviews 23:3-4, pages 355-373.
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Articles from other publishers (14)

Manjunath P. Pai. 2018. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions. Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions 57 86 .
Donald J. KellermanAmy ForstDaniel L. CombsScott BorlandShashidhar Kori. (2013) Assessment of the Consistency of Absorption of Dihydroergotamine Following Oral Inhalation: Pooled Results from Four Clinical Studies. Journal of Aerosol Medicine and Pulmonary Drug Delivery 26:5, pages 297-306.
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D Kellerman, S Kori, A Forst, J Chang, S Febbraro, L WuTann, T Thomas, G Taylor & DW Dodick. (2011) Lack of drug interaction between the migraine drug MAP0004 (orally inhaled dihydroergotamine) and a CYP3A4 inhibitor in humans. Cephalalgia 32:2, pages 150-158.
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Manjunath P. Pai. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 243 275 .
Kenneth Thummel & Mary Paine. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 421 451 .
Mervyn J. Eadie. (2001) Clinically Significant Drug Interactions with Agents Specific For Migraine Attacks. CNS Drugs 15:2, pages 105-118.
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C. Bensoussan, M. Delaforge & D. Mansuy. (1995) Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. Biochemical Pharmacology 49:5, pages 591-602.
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Marie-Anne PEYRONNEAU, Marcel DELAFORGE, Rene RIVIERE, Jean-Paul RENAUD & Daniel MANSUY. (1994) High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine. European Journal of Biochemistry 223:3, pages 947-956.
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Marcel Delaforge, Denis Servent, Philippe Wirsta, Claire Ducrocq, Daniel Mansuy & Maryse Lenfant. (1993) Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: Subsequent formation of nitric oxide. Chemico-Biological Interactions 86:2, pages 103-117.
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Jean-Luc Boucher, Agnès Genet, Sandrine Vadon, Marcel Delaforge, Yann Henry & Daniel Mansuy. (1992) Cytochrome P450 catalyzes the oxidation of Nω-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline. Biochemical and Biophysical Research Communications 187:2, pages 880-886.
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JM Grognet & E Ezan. (1991) Dosage des alcaloïdes de l'ergot de seigle. Apport de l'immunologie analytique. Immuno-analyse & Biologie Spécialisée 6:5, pages 25-30.
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Jean‐Paul RENAUD, Christophe CULLIN, Denis POMPON, Philippe BEAUNE & Daniel MANSUY. (2005) Expression of human liver cytochrome P 450 IIIA4 in yeast . European Journal of Biochemistry 194:3, pages 889-896.
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M. Delaforge & E. Sartori. (1990) In vivo effects of erythromycin, oleandomycin and erythralosamine derivatives on hepatic cytochrome P-450. Biochemical Pharmacology 40:2, pages 223-228.
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E. Sartori & M. Delaforge. (1990) Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16α-carbonitrile and macrolide antibiotics. Implications for drug interactions. Chemico-Biological Interactions 73:2-3, pages 297-307.
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