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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
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Original Article

Induction of monooxygenase and transferase activities in rat by dietary administration of flavonoids

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Pages 1379-1386 | Received 28 Jan 1989, Accepted 10 Jun 1989, Published online: 30 Sep 2009

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Silvia Wein, Rainer Cermak, Siegfried Wolffram & Peter Langguth. (2012) Chronic quercetin feeding decreases plasma concentrations of salicylamide phase II metabolites in pigs following oral administration. Xenobiotica 42:5, pages 477-482.
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MistyR. Saracino & JohannaW. Lampe. (2007) Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention. Nutrition and Cancer 59:2, pages 121-141.
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V. Breinholt, S. T. Lauridsen & L. O. Dragsted. (1999) Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. Xenobiotica 29:12, pages 1227-1240.
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S. E. NIELSEN, V. BREINHOLT, U. JUSTESEN, C. CORNETT & L. O. DRAGSTED. (1998) In vitro biotransformation of flavonoids by rat liver microsomes. Xenobiotica 28:4, pages 389-401.
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S. Gradelet, J. Leclerc, M-H. Siess & P. O. Astorg. (1996) β-Apo-8′-carotenal, but not β-carotene, is a strong inducer of liver cytochromes P4501A1 and 1A2 in rat. Xenobiotica 26:9, pages 909-919.
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Catherine Chaumontet, Marc Suschetet, Esther Honikman‐Leban, VladimirA. Krutovskikh, Raymond Berges, Anne‐Marie Le Bon, Christine Heberden, MajdiM. Shahin, Hiroshi Yamasaki & Paule Martel. (1996) Lack of tumor‐promoting effects of flavonoids: Studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Nutrition and Cancer 26:3, pages 251-263.
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RaymondW. Nims & RonaldA. Lubet. (1995) Induction of cytochrome p‐450 in the norway rat, rattus norvegicus, following exposure to potential environmental contaminants. Journal of Toxicology and Environmental Health 46:3, pages 271-292.
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M. T. Obermeier, R. E. White & C. S. Yang. (1995) Effects of bioflavonoids on hepatic P450 activities. Xenobiotica 25:6, pages 575-584.
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M.-C. Canivenc-Lavier, C. Brunold, M.-H. Siess & M. Suschetet. (1993) Evidence for tangeretin O-demethylation by rat and human liver microsomes. Xenobiotica 23:3, pages 259-266.
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Marie‐Hélène Siess, Anne Marie Le Bon & Marc Suschetet. (1992) Dietary modification of drug‐metabolizing enzyme activities: Dose‐response effect of flavonoids. Journal of Toxicology and Environmental Health 35:3, pages 141-152.
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Articles from other publishers (33)

Gary Williamson, Colin D. Kay & Alan Crozier. (2018) The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective. Comprehensive Reviews in Food Science and Food Safety 17:5, pages 1054-1112.
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Tseye-Oidov Odbayar, Toshinori Kimura, Tojiro Tsushida & Takashi Ide. (2009) Isoenzyme-specific up-regulation of glutathione transferase and aldo-keto reductase mRNA expression by dietary quercetin in rat liver. Molecular and Cellular Biochemistry 325:1-2, pages 121-130.
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Sang K. Kim, Mohamed A. Abdelmegeed & Raymond F. Novak. (2006) THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK. Drug Metabolism and Disposition 34:4, pages 683-689.
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Jadwiga Jodynis-Liebert, Irena Matławska, Wiesława Bylka & Marek Murias. (2005) Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. Journal of Ethnopharmacology 97:2, pages 351-358.
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A.M. Le Bon, L. Ziegler & M. Suschetet. 2005. Food and Cancer Prevention. Food and Cancer Prevention 217 222 .
Yun-Jeong Hong & Alyson E. Mitchell. (2004) Metabolic Profiling of Flavonol Metabolites in Human Urine by Liquid Chromatography and Tandem Mass Spectrometry. Journal of Agricultural and Food Chemistry 52:22, pages 6794-6801.
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S.A. Andújar, M.A. Filippa, F.H. Ferretti & S.E. Blanco. (2003) Isomerization of 4′-methoxy-flavanone in alkaline medium. Determination of the enolate formation constant. Journal of Molecular Structure: THEOCHEM 636:1-3, pages 157-166.
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Ahmet Kahraman & Mine Erden Inal. (2002) Protective effects of quercetin on ultraviolet A light‐induced oxidative stress in the blood of rat. Journal of Applied Toxicology 22:5, pages 303-309.
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C Teyssier, M.-J Amiot, N Mondy, J Auger, R Kahane & M.-H Siess. (2001) Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food and Chemical Toxicology 39:10, pages 981-987.
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Alicja Mortensen, Vibeke Breinholt, Tórur Dalsgaard, Henrik Frandsen, Søren T. Lauridsen, Jennie Laigaard, Bent Ottesen & Jens-Jørgen Larsen. (2001) 17β-Estradiol but not the phytoestrogen naringenin attenuates aortic cholesterol accumulation in WHHL rabbits. Journal of Lipid Research 42:5, pages 834-843.
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Miroslav Machala, Renata Kubínová, Pavla Hořavová & Václav Suchý. (2001) Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari : modulations of drug‐metabolizing enzymes and antioxidant activity . Phytotherapy Research 15:2, pages 114-118.
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P Debersac, M.-F Vernevaut, M.-J Amiot, M Suschetet & M.-H Siess. (2001) Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food and Chemical Toxicology 39:2, pages 109-117.
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Gary W Barone, Bill J Gurley, Beverley L Ketel, Meredith L Lightfoot & Sameh R Abul-Ezz. (2016) Drug Interaction between St. John's Wort and Cyclosporine. Annals of Pharmacotherapy 34:9, pages 1013-1016.
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Taro Kishida, Kunitaka Nashiki, Toru Izumi & Kiyoshi Ebihara. (2000) Soy Isoflavonoid Aglycons Genistein and Daidzein Do Not Increase the Cytochrome P-450 Content of the Liver Microsomes of Mice. Journal of Agricultural and Food Chemistry 48:9, pages 3872-3875.
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B. Premalatha & P. Sachdanandam. (2000) Potency of Semecarpus anacardium Linn. Nut milk extract against aflatoxin B1-induced hepatocarcinogenesis: reflection on microsomal biotransformation enzymes. Pharmacological Research 42:2, pages 161-166.
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A.C. Devia, F.H. Ferretti, C.A. Ponce & F. Tomás. (1999) Conformational equilibrium and intramolecular hydrogen bond of 4′X and 4X substituted 2′(OH)chalcones. Journal of Molecular Structure: THEOCHEM 493:1-3, pages 187-197.
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E.Hazel Rodgers & M.Helen Grant. (1998) The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells. Chemico-Biological Interactions 116:3, pages 213-228.
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Michael Aviram & Bianca Fuhrman. (1998) Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 137, pages S45-S50.
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Toshihiko Makino, Shinya Sehata, Isao Igarashi, Toshiyuki Watanabe, Yoshihiko Ohashi, Sunao Manabe & Takashi Yamoto. (1998) Induction of Glutathione S-Transferases and Hepatocellular Proliferating Activities in the Rat Liver Treated with tert-Butylated Hydroxyanisole, 1,2-Bis(2-Pyridyl)Ethylene, and Phenobarbital.. Journal of Toxicologic Pathology 11:3, pages 183-189.
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CA Musonda, N. Helsby & JK Chipman. (2016) Effects of quercetin on drug metabolizing enzymes and oxidation of 2', 7-dichlorofluorescin in HepG2 cells. Human & Experimental Toxicology 16:12, pages 700-708.
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Marie-Chantal Canivenc-Lavier, Marie-France Vernevaut, Muriel Totis, Marie-Hélène Siess, Jacques Magdalou & Marc Suschetet. (1996) Comparative effects of flavonoids and model inducers on drug-metabolizing enzymes in rat liver. Toxicology 114:1, pages 19-27.
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Claudine Manach, Françoise Regerat, Odile Texier, Georgine Agullo, Christian Demigne & Christian Remesy. (1996) Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids. Nutrition Research 16:3, pages 517-544.
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Jorma T. Kumpulainen & Jukka T. SalonenLars O. Dragsted. 1996. Natural antioxidants and food quality in atherosclerosis and cancer prevention. Natural antioxidants and food quality in atherosclerosis and cancer prevention 365 372 .
Marie-Hélène Siess, Anne-Marie Le Bon, Marie-Chantal Canivenc-Lavier, Marie-Josèphe Amiot, Sylvie Sabatier, Serge Y. Aubert & Marc Suschetet. (1996) Flavonoids of Honey and Propolis:  Characterization and Effects on Hepatic Drug-Metabolizing Enzymes and Benzo[ a ]pyrene−DNA Binding in Rats . Journal of Agricultural and Food Chemistry 44:8, pages 2297-2301.
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A.A. Andrianaivo-Rafehivola, M.-H. Siess & E.M. Gaydou. (1995) Modifications of hepatic drug metabolizing enzyme activities in rats fed baobab seed oil containing cyclopropenoid fatty acids. Food and Chemical Toxicology 33:5, pages 377-382.
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Jean A. Boutin. (1994) Tyrosine protein kinase inhibition and cancer. International Journal of Biochemistry 26:10-11, pages 1203-1226.
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Pierre Astorg, Raymond Bergès & Marc Suschetet. (1994) Induction of γGT- and GST-P positive foci in the liver of rats treated with 2-nitropropane or propane 2-nitronate. Cancer Letters 79:1, pages 101-106.
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P. Astorg, S. Gradelet, J. Leclerc, M.-C. Canivenc & M.-H. Siess. (1994) Effects of β-Carotene and canthaxanthin on liver xenobiotic-metabolizing enzymes in the rat. Food and Chemical Toxicology 32:8, pages 735-742.
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Junming Cao, Jean-Paul Blond & Jean Bézard. (1993) Inhibition of fatty acid Δ6- and Δ5-desaturation by cyclopropene fatty acids in rat liver microsomes. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1210:1, pages 27-34.
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Yamada Hydeyuki, Fujisaki Hiroshi, Kaneko Hayato, Ishii Yuji, Hamaguchi Tomoyuki & Oguri Kazuta. (1993) Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2b1 and CYP2b2. Biochemical Pharmacology 45:9, pages 1783-1789.
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Anne-Marie Le Bon, Marie-Helene Siess & Marc Suschetet. (1992) Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. Chemico-Biological Interactions 83:1, pages 65-71.
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Michael R. Franklin. (1991) Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450. Toxicology and Applied Pharmacology 111:1, pages 24-32.
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Dorothy C. Gosting, M. Ellin Doyle, Carol E. Steinhart & Barbara A. Cochrane. 1991. Food Safety 1990. Food Safety 1990 3 43 .

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