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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
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Original Article

Metabolism of a new dihydropyridine calcium antagonist in rats and dogs

F. Takayama Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, 9-3 2-chome, Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
Y. Iwasawa Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, 9-3 2-chome, Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
K. Saito Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, 9-3 2-chome, Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
K. Shiratori Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, 9-3 2-chome, Shimomeguro, Meguro-ku, Tokyo, 153, Japan
&
M. Ohtawa Central Research Laboratories, Banyu Pharmaceutical Co. Ltd, 9-3 2-chome, Shimomeguro, Meguro-ku, Tokyo, 153, Japan
Pages 1407-1420 | Received 13 Feb 1989, Accepted 14 Jul 1989, Published online: 30 Sep 2009

Citations (7)

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H. KOBAYASHI*S. KOBAYASHI. (1998) Absorption, distribution, metabolism and excretion of 14C-labelled enantiomers of the calcium channel blocker benidipine after oral administration to rat. Xenobiotica 28:2, pages 179-197.
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H. Nakabeppu, M. Asada, T. Oda, Y. Shinozaki & T. Yajima. (1996) Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica 26:2, pages 229-239.
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N. Ogawa, K. Mizuno, K. Fukushima, T. Suwa & T. Satoh. (1993) Metabolic fate of a new dihydropyridine calcium antagonist, CD-349, in rat and dog. Xenobiotica 23:7, pages 747-759.
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P. Grossi, M. Pellegatti, G. Vigelli, J. Ayrton, B. A. Duncan & J. Maltas. (1992) Lacidipine metabolism in rat and dog: identification and synthesis of main metabolites. Xenobiotica 22:8, pages 899-916.
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F. Takayama, K. Saito, Y. Ishii, K. Shiratori & M. Ohtawa. (1991) Sex difference in the stereoselective metabolism of a new dihydropyridine calcium channel blocker, in rat studies in vivo and in vitro. Xenobiotica 21:5, pages 557-568.
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Articles from other publishers (2)

M. Stefek, V. Faberova, S. Musil & I. Kakalik. (2001) Urinary excretion of the 1,4-dihydropyridine calcium antagonist VULM 993 and its metabolites in the rat. European Journal of Drug Metabolism and Pharmacokinetics 26:4, pages 221-226.
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Yuichi Hattori & Morio Kanno. (2007) Pharmacology and Therapeutic Potential of Lemildipine, a Highly Vasculoselective Dihydropyridine Derivative with Slow Onset and Long Duration of Action. Cardiovascular Drug Reviews 14:4, pages 317-333.
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