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Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
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Original Article

The isolation, identification and structure of a new hydroxylated metabolite of benzbromarone in man

J. X. De Vries Abteilung Klinische Pharmakologie, Medizinische Klinik der Universität, Bergheimerstr, 58, 6900, Heidelberg, FRG
,
I. Walter-Sack Abteilung Klinische Pharmakologie, Medizinische Klinik der Universität, Bergheimerstr, 58, 6900, Heidelberg, FRG
,
A. Ittensohn Abteilung Klinische Pharmakologie, Medizinische Klinik der Universität, Bergheimerstr, 58, 6900, Heidelberg, FRG
&
E. Weber Abteilung Klinische Pharmakologie, Medizinische Klinik der Universität, Bergheimerstr, 58, 6900, Heidelberg, FRG
Pages 1461-1470 | Received 17 Jan 1989, Accepted 15 Jun 1989, Published online: 30 Sep 2009

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J. X. De Vries, I. Walter-Sack, A. Voss, W. Forster, P. Ilisistegui Pons, F. Stoetzer, M. Spraul, M. Ackermann & G. Moyna. (1993) Metabolism of benzbromarone in man: structures of new oxidative metabolites, 6-hydroxy- and 1″-oxo-benzbromarone, and the enantioselective formation and elimination of 1″-hydroxybenzbromarone. Xenobiotica 23:12, pages 1435-1450.
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Articles from other publishers (13)

Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan & Eric Chun Yong Chan. (2021) Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone. Molecular Pharmacology 99:4, pages 266-276.
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Kaoru Kobayashi, Eri Kajiwara, Masayuki Ishikawa, Hanaka Mimura, Hidenobu Oka, Yoko Ejiri, Masaya Hosoda & Kan Chiba. (2013) Cytotoxic Effects of Benzbromarone and Its 1′-Hydroxy Metabolite in Human Hepatocarcinoma FLC4 Cells Cultured on Micro-space Cell Culture Plates. Drug Metabolism and Pharmacokinetics 28:3, pages 265-268.
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David S. NewcombeDavid S. Newcombe. 2013. Gout. Gout 291 385 .
Kaoru Kobayashi, Eri Kajiwara, Masayuki Ishikawa, Hidenobu Oka & Kan Chiba. (2012) Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes. Biopharmaceutics & Drug Disposition 33:8, pages 466-473.
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HO JUNG SHIN, MICHIO TAKEDA, ATSUSHI ENOMOTO, MASAAKI FUJIMURA, HIROKI MIYAZAKI, NAOHIKO ANZAI & HITOSHI ENDOU. (2011) Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. Nephrology 16:2, pages 156-162.
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Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitsu Imai, Yasuhiro Katoh, Naoki Inui, Kazuhiko Takeuchi, Takashi Ishizaki, Shizuo Yamada, Kyoichi Ohashi, Noriyuki Namiki & Hiroshi Watanabe. (2010) Benzbromarone Pharmacokinetics and Pharmacodynamics in Différent Cytochrome P450 2C9 Genotypes. Drug Metabolism and Pharmacokinetics 25:6, pages 605-610.
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Matthew G. McDonald & Allan E. Rettie. (2007) Sequential Metabolism and Bioactivation of the Hepatotoxin Benzbromarone: Formation of Glutathione Adducts From a Catechol Intermediate. Chemical Research in Toxicology 20:12, pages 1833-1842.
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I. A. Blair. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 41 84 .
Emilio Gelpi. (1992) Trends in biochemical and biomedical applications of mass spectrometry. International Journal of Mass Spectrometry and Ion Processes 118-119, pages 683-721.
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Emilio Gelpi. 1992. Advances in Mass Spectrometry. Advances in Mass Spectrometry 683 721 .
P.J. Arnold, R. Guserle, V. Luckow, R. Hemmer & H. Grote. (1991) Liquid chromatography-mass spectrometry in metabolic research. Journal of Chromatography A 554:1-2, pages 267-280.
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I. Walter-Sack, J. X. de Vries, A. Ittensohn & E. Weber. (1990) Rapid and slow benzbromarone elimination phenotypes in man: benzbromarone and metabolite profiles. European Journal of Clinical Pharmacology 39:6, pages 577-581.
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I. Walter-Sack, U. Gresser, M. Adjan, I. Kamilli, A. Ittensohn, J. X. de Vries, E. Weber & N. Zöllner. (1990) Variation of benzbromarone elimination in man — a population study. European Journal of Clinical Pharmacology 39:2, pages 173-176.
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