Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 19, 1989 - Issue 12
Submit an article Journal homepage
12
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Teratogenicity of phenylhydantoins in an in vitro system: Molecular orbital-generated quantitative structure-toxicity relationships

L. P. Brown University of Surrey, Department of Biochemistry, Molecular Toxicology Group, Guildford, Surrey, GU2 5XH, UK
,
D. F. V. Lewis University of Surrey, Department of Biochemistry, Molecular Toxicology Group, Guildford, Surrey, GU2 5XH, UK
,
O. P. Flint ICI plc, Pharmaceuticals Division, Safety of Medicines Department, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
,
T. C. Orton ICI plc, Pharmaceuticals Division, Safety of Medicines Department, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
&
G. G. Gibson University of Surrey, Department of Biochemistry, Molecular Toxicology Group, Guildford, Surrey, GU2 5XH, UK
Pages 1471-1481 | Received 21 Jul 1988, Accepted 16 Aug 1989, Published online: 30 Sep 2009

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Corwin Hansen, Bruce R. Telzer & Litai Zhang. (1995) Comparative QSAR in Toxicology: Examples from Teratology and Cancer Chemotherapy of Aniline Mustards. Critical Reviews in Toxicology 25:1, pages 67-89.
Read now
D. F. V. Lewis, C. Ioannides & D. V. Parke. (1994) Interaction of a series of nitriles with the alcohol-inducible isoform of P450: Computer analysis of structure—activity relationships. Xenobiotica 24:5, pages 401-408.
Read now

Articles from other publishers (10)

Dali Wang, Yue Gu, Min Zheng, Wei Zhang, Zhifen Lin & Ying Liu. (2017) A Mechanism-based QSTR Model for Acute to Chronic Toxicity Extrapolation: A Case Study of Antibiotics on Luminous Bacteria. Scientific Reports 7:1.
Crossref
Bhavesh K. Ahir & Margaret K. Pratten. (2016) The impact of caffeine on connexin expression in the embryonic chick cardiomyocyte micromass culture system. Journal of Applied Toxicology 36:7, pages 903-913.
Crossref
Mark T. D. Cronin & Andrew P. Worth. (2008) (Q)SARs for Predicting Effects Relating to Reproductive Toxicity. QSAR & Combinatorial Science 27:1, pages 91-100.
Crossref
David F. V. Lewis. (2003) Quantitative structure–activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s. InflammoPharmacology 11:1, pages 43-73.
Crossref
Mark T. D. Cronin & John C. Dearden. (2006) QSAR in Toxicology. 3. Prediction of Chronic Toxicities. Quantitative Structure-Activity Relationships 14:4, pages 329-334.
Crossref
Oliver P. Flint. (1993) In vitro tests for teratogens: Desirable endpoints, test batteries and current status of the micromass teratogen test. Reproductive Toxicology 7, pages 103-111.
Crossref
James E. Ridings, David T. Manallack, Martin R. Saunders, John A. Baldwin & David J. Livingstone. (1992) Multivariate quantitative structure-toxicity relationships in a series of dopamine mimetics. Toxicology 76:3, pages 209-217.
Crossref
David F. V. Lewis. 1992. Reviews in Computational Chemistry. Reviews in Computational Chemistry 173 222 .
Michael Balls, Michael Garle & Richard Clothier. 1991. Animals and Alternatives in Toxicology. Animals and Alternatives in Toxicology 313 339 .
Oliver P. Flint. (2020) In Vitro Toxicity Testing: Purpose, Validation and Strategy . Alternatives to Laboratory Animals 18:1_part_1, pages 11-18.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.