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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 1
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Original Article

Metabolism of low-dose paracetamol in patients with chronic neurological disease

G. B. Steventon School of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
,
M. T. E. Heafield Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
,
R. H. Waring School of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK
,
A. C. Williams Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
,
S. Sturman Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
&
M. Green Department of Neurology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
Pages 117-122 | Received 24 Apr 1989, Accepted 18 Aug 1989, Published online: 27 Aug 2009

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JanetK. Kern, BruceD. Grannemann, MadhukarH. Trivedi & JamesB. Adams. (2007) Sulfhydryl-Reactive Metals in Autism. Journal of Toxicology and Environmental Health, Part A 70:8, pages 715-721.
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JanetK. Kern & AnneM. Jones. (2006) Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism. Journal of Toxicology and Environmental Health, Part B 9:6, pages 485-499.
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L. Peters, G. B. Steventon, S. Green, S. Sturman, R. H. Waring & A. C. Williams. (1994) D-Penicillamine metabolism in neurodegenerative diseases: An in vivo/in vitro sulphydryl methylation study. Xenobiotica 24:10, pages 1013-1020.
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H. Bradley, R. H. Waring, P. Emery & V. Arthur. (1991) Metabolism of low-dose paracetamol in patients with rheumatoid arthritis. Xenobiotica 21:5, pages 689-693.
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Articles from other publishers (18)

Natália Marto, Judit Morello, Alexandra M. M. Antunes, Sofia Azeredo, Emília C. Monteiro & Sofia A. Pereira. (2021) A simple method to measure sulfonation in man using paracetamol as probe drug. Scientific Reports 11:1.
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Nurashikin Abd Azis, Illyas Md Isa, Norhayati Hashim, Mohamad Syahrizal Ahmad, Siti Nur Akmar Mohd Yazid, Mohamad Idris Saidin, Suyanta M.Si, Rahadian Zainul, Alizar Ulianas, Mawardi Mawardi & Siriboon Mukdasai. (2020) Synergistic Effect of Zinc/aluminium-layered Double Hydroxide-clopyralid Carbon Nanotubes Paste Electrode in the Electrochemical Response of Dopamine, Acetaminophen, and Bisphenol A. International Journal of Electrochemical Science 15:9, pages 9088-9107.
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Janet Kern, Boyd Haley, David Geier, Lisa Sykes, Paul King & Mark Geier. (2013) Thimerosal Exposure and the Role of Sulfation Chemistry and Thiol Availability in Autism. International Journal of Environmental Research and Public Health 10:8, pages 3771-3800.
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T. Andrew ClaytonDavid Baker, John C. LindonJeremy R. Everett & Jeremy K. Nicholson. (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proceedings of the National Academy of Sciences 106:34, pages 14728-14733.
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Soohyun Lee, Paul A. Dawson, Amitha K. Hewavitharana, P. Nicholas Shaw & Daniel Markovich. (2006) Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. Hepatology 43:6, pages 1241-1247.
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Paul Anthony Dawson, Sarah Elizabeth Steane & Daniel Markovich. (2004) Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Behavioural Brain Research 154:2, pages 457-463.
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G.B. Steventon, RH. Waring & A.C. Williams. (2003) An Investigation into the Inter-Relationships of Sulphur Xeno- Biotransformation Pathways in Parkinson's and Motor Neurone Diseases. Drug Metabolism and Drug Interactions 19:4.
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Kerstin Naidu Sjöswärd, Martin Josefsson, Johan Ahlner, Rolf G.G. Andersson & Birgitta Schmekel. (2003) Metabolism of Salbutamol Differs between Asthmatic Patients and Healthy Volunteers. Pharmacology & Toxicology 92:1, pages 27-32.
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G.B. Steventon, S. Sturman, R.H. Waring & A.C. Williams. (2001) A Review of Xenobiotic Metabolism Enzymes in Parkinson's Disease and Motor Neuron Disease. Drug Metabolism and Drug Interactions 18:2.
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Antonino Alberti, Patrizia Pirrone, Maurizio Elia, Rosemary H Waring & Corrado Romano. (1999) Sulphation deficit in “low-functioning” autistic children: a pilot study. Biological Psychiatry 46:3, pages 420-424.
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Haderslev, Sonne, Poulsen & Loft. (2002) Paracetamol metabolism in patients with ulcerative colitis. British Journal of Clinical Pharmacology 46:5, pages 513-516.
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Lynn AdamsSusan Conn. (2016) Nutrition and Its Relationship to Autism. Focus on Autism and Other Developmental Disabilities 12:1, pages 53-58.
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G.B. Steventon, S.C. Mitchell & R.H. Waring. (1996) Human Metabolism of Paracetamol (Acetaminophen) at Different Dose Levels. Drug Metabolism and Drug Interactions 13:2.
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J.M. Ngong & R.H. Waring. (1994) ORCADIAN RHYTHMS OF PARACETAMOL METABOLISM IN HEALTHY SUBJECTS; A PRELIMINARY REPORT. Drug Metabolism and Drug Interactions 11:4, pages 317-330.
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Mervyn H. Davies, Josephine M. Ngong, Mehmet Yucesoy, Subrat K. Acharya, Charles O. Mills, Judith B. Weaver, Rosemary H. Waring & Elwyn Elias. (1994) The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy?. Journal of Hepatology 21:6, pages 1127-1134.
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A. C. Williams, G. B. Steventon, S. Sturman & R. H. Waring. (1991) Hereditary variation of liver enzymes involved with detoxification and neurodegenerative disease. Journal of Inherited Metabolic Disease 14:4, pages 431-435.
Crossref
Adrian Williams. (1991) Ecogenetics, xenobiotic biochemistry and neurological disease. Journal of Neurology 238:4, pages 187-190.
Crossref
A. C. Williams, G. B. Steventon, S. Sturman & R. H. Waring. 1991. Journal of Inherited Metabolic Disease. Journal of Inherited Metabolic Disease 431 435 .

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