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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 10
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Research Article

1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat

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Pages 1035-1042 | Received 04 Oct 1989, Accepted 23 Apr 1990, Published online: 22 Sep 2008

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Makoto Take, Michiharu Matsumoto, Tetsuya Takeuchi, Mitsuru Haresaku, Hitomi Kondo, Hideki Senoh, Yumi Umeda, Takeji Takamura-Enya & Shoji Fukushima. (2014) Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure. Journal of Environmental Science and Health, Part A 49:12, pages 1341-1348.
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P. Kestell & S.C. Mitchell. (1996) The Toxicity of Sulfonium Compounds. Sulfur reports 17:2, pages 159-176.
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Aleksandrs Odinecs, Stefano Maso, Giampaolo Nicoletto, Livia Secondin & Andrea Trevisan. (1995) Mechanism of Sex-Related Differences in Nephrotoxicity of 1,2-Dichloropropane in Rats. Renal Failure 17:5, pages 517-524.
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Ronald T. H. van Welie, Rob G. J. M. van Dijck, Nico P. E. Vermeulen & Nico J. van Sittert. (1992) Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals. Critical Reviews in Toxicology 22:5-6, pages 271-306.
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Ryoya Takizawa, Sahoko Ichihara, Cai Zong, Kazuo Kinoshita, Toshihiro Sakurai, Akihiko Ikegami, Nathan Mise & Gaku Ichihara. (2021) 1,2-Dichloropropane induces γ-H2AX expression in human cholangiocytes only in the presence of macrophages. Toxicology Letters 349, pages 134-144.
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Xiao Zhang, Cai Zong, Lingyi Zhang, Edwin Garner, Shigeyuki Sugie, Chinyen Huang, Wenting Wu, Jie Chang, Toshihiro Sakurai, Masashi Kato, Sahoko Ichihara, Shinji Kumagai & Gaku Ichihara. (2018) Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes. Toxicological Sciences 162:2, pages 559-569.
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Makoto Take, Tetsuya Takeuchi, Shigeyuki Hirai, Kenji Takanobu, Michiharu Matsumoto, Shoji Fukushima & Jun Kanno. (2017) Distribution of 1,2-dichloropropane in blood and other tissues of rats after oral administration. The Journal of Toxicological Sciences 42:2, pages 121-128.
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Yu Toyoda, Tappei Takada & Hiroshi Suzuki. (2017) Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma. Oxidative Medicine and Cellular Longevity 2017, pages 1-9.
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Yukie Yanagiba, Tetsuya Suzuki, Megumi Suda, Rieko Hojo, Frank J Gonzalez, Tamie Nakajima & Rui-Sheng Wang. (2016) Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage. Toxicology and Industrial Health 32:9, pages 1589-1597.
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Yu Toyoda, Tappei Takada & Hiroshi Suzuki. (2016) Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis. Scientific Reports 6:1.
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Lingyi Zhang, Cai Zong, Sahoko Ichihara, Hisao Naito, Shinya Toyokuni, Shinji Kumagai & Gaku Ichihara. (2015) A trial to find appropriate animal models of dichloropropane‐induced cholangiocarcinoma based on the hepatic distribution of glutathione S‐transferases. Journal of Occupational Health 57:6, pages 548-554.
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Toshio Kawai, Koji Mitsuyoshi & Masayuki Ikeda. (2015) Promising biological monitoring for occupational 1,2‐Dichloropropane exposure by urinalysis for unmetabolized solvent. Journal of Occupational Health 57:2, pages 197-199.
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Kevin H. Kensler, Stephen L. Slocum, Dionysios V. Chartoumpekis, Patrick M. Dolan, Natalie M. Johnson, Zoran Ilic, Dana R. Crawford, Stewart Sell, John D. Groopman, Thomas W. Kensler & Patricia A. Egner. (2014) Genetic or Pharmacologic Activation of Nrf2 Signaling Fails to Protect Against Aflatoxin Genotoxicity in Hypersensitive GSTA3 Knockout Mice. Toxicological Sciences 139:2, pages 293-300.
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Andrea Trevisan, Paola Meneghetti, Stefano Maso & Ornella Troso. (2016) In-Vitro Mechanisms of 1,2-Dichloropropane Nephrotoxicity using the Renal Cortical Slice Model. Human & Experimental Toxicology 12:2, pages 117-121.
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Andrea Trevisan, Paola Meneghetti, Stefano Maso, Livia Secondin & Giampaolo Nicoletto. (1992) Sex- and age-related nephrotoxicity due to 1,2-dichloropropane in vitro. Archives of Toxicology 66:9, pages 641-645.
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Thomas A. Baillie. (1992) Advances in the application of mass spectrometry to studies of drug metabolism, pharmacokinetics and toxicology. International Journal of Mass Spectrometry and Ion Processes 118-119, pages 289-314.
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A. L. Burlingame, T. A. Baillie & D. H. Russell. (2002) Mass spectrometry. Analytical Chemistry 64:12, pages 467-502.
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Charles Timchalk, Mark D. Dryzga, Fred A. Smith & Michael J. Bartels. (1991) Disposition and metabolism of [14C]1,2-dichloropropane following oral and inhalation exposure in Fischer 344 rats. Toxicology 68:3, pages 291-306.
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