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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 11
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Original Article

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

A. R. Boobis Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
D. Sesardic Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK; Division of Bacteriology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Herts, EN6 6QG, UK
,
B. P. Murray Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
R. J. Edwards Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
A. M. Singleton Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
K. J. Rich Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
S. Murray Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
,
R. De La Torre Department of Pharmacology, Institut Municipal D'Investigaciö Mèdica, 08003, Barcelona, Spain
,
J. Segura Department of Pharmacology, Institut Municipal D'Investigaciö Mèdica, 08003, Barcelona, Spain
,
O. Pelkonen Department of Pharmacology, Institut Municipal D'Investigaciö Mèdica, 08003, Barcelona, Spain
,
M. Pasanen Department of Pharmacology and Toxicology, University of Oulu, SF-90220, Oulu, Finland
,
S. Kobayashi Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK; Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142, Japan
,
T. Zhi-guang Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK; Department of Pharmacology, Chongqing University of Medical Sciences, Chongqing, 630041, People's Republic of China
&
D. S. Davies Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 ONN, UK
 show all
Pages 1139-1161 | Received 05 Mar 1990, Accepted 15 May 1990, Published online: 27 Aug 2009

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Sophia Yui Kau Fong & Zhong Zuo. (2014) Species difference in the inhibitory potentials of non-steroidal anti-inflammatory drugs on the hepatic sulfation and glucuronidation of bioactive flavonoids: differential observations among common inhibition parameters. Xenobiotica 44:5, pages 417-431.
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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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Shufeng Zhou, Philip Kestell & James W. Paxton. (2002) PREDICTING PHARMACOKINETICS AND DRUG INTERACTIONS IN PATIENTS FROM IN VITRO AND IN VIVO MODELS: THE EXPERIENCE WITH 5,6-DIMETHYLXANTHENONE-4-ACETIC ACID (DMXAA), AN ANTI-CANCER DRUG ELIMINATED MAINLY BY CONJUGATION. Drug Metabolism Reviews 34:4, pages 751-790.
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SK. Bezek, M. Kukan, W. F. Pool & T. F. Woolf. (1996) The effect of cytochromes P4501A induction and inhibition on the disposition of the cognition activator tacrine in rat hepatic preparations. Xenobiotica 26:9, pages 935-946.
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Y. Fujimak, H. Hakusui & Y. Yamazoe. (1996) Nefiracetam hydroxylation by rat liver microsomes and expressed human cytochrome P450s. Xenobiotica 26:8, pages 821-830.
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R. W. Nims, P. R. Sinclair, J. F. Sinclair, K. H. Dragnev, C. R. Jones, D. W. Mellini, P. E. Thomas & R. A. Lubet. (1993) Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes. Xenobiotica 23:12, pages 1411-1426.
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F. Berthou, B. Guillois, C. Riche, Y. Dreano, E. Jacqz-Aigrain & P. H. Beaune. (1992) Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 22:6, pages 671-680.
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