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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 11
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Original Article

Design of toxicokinetic studies

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Pages 1187-1199 | Received 07 Oct 1989, Accepted 23 Apr 1990, Published online: 27 Aug 2009

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Read on this site (10)

Rakesh Dixit, Jim Riviere, Kannan Krishnan & Melvin Andersen. (2003) Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment. Journal of Toxicology and Environmental Health, Part B 6:1, pages 1-40.
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D. K. Walker, K. C. Beaumont, P. Comby, K. M. Evans, J. I. Gedge, R. C. Halliday, S. J. Roffey & P. A. Wright. (2001) Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog. Xenobiotica 31:8-9, pages 651-664.
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D. A. SMITH. (1997) Pharmacokinetics and pharmacodynamics in toxicology. Xenobiotica 27:5, pages 513-525.
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M. J. Humphrey. (1996) Application of Metabolism and Pharmacokinetic Studies to the Drug Discovery Process. Drug Metabolism Reviews 28:3, pages 473-489.
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Y. Tanaka, H. Shimojyo, T. Hata, M. Hashimoto & H. Noguchi. (1994) Toxicokinetics of zenarestat, an aldose reductase inhibitor in animals and man. Xenobiotica 24:5, pages 461-471.
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D. A. Smith, H. S. Rasmussen, D. A. Stopher & D. K. Walker. (1992) Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man. Xenobiotica 22:6, pages 709-719.
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D. A. Smith, K. Beaumont, N. J. Cussans, M. J. Humphrey, S. G. Jezequel, D. J. Rance, D. A. Stopher & D. K. Walker. (1992) Bioanalytical data in decision making: Discovery and development. Xenobiotica 22:9-10, pages 1195-1205.
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Ferhat Özen & Gökhan Eraslan. (2022) Toxicokinetic of cyphenothrin in rabbits. Environmental Science and Pollution Research 29:21, pages 31541-31550.
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Eun-Jeong Choi, Go-Wun Choi, Seung-Jeong Yang, Yong-Bok Lee & Hea-Young Cho. (2018) Pharmacokinetic Profile of Kaurenoic Acid after Oral Administration of Araliae Continentalis Radix Extract Powder to Humans. Pharmaceutics 10:4, pages 253.
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Jianghong Fan & Inés A.M. de Lannoy. (2014) Pharmacokinetics. Biochemical Pharmacology 87:1, pages 93-120.
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Jos G.M. Bessems & Liesbeth Geraets. (2013) Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach. Regulatory Toxicology and Pharmacology 67:3, pages 325-334.
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Alexander V. LyubimovRoger N. Hayes. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Claude Charuel. 2011. Pharmaceutical Toxicology in Practice. Pharmaceutical Toxicology in Practice 83 107 .
Clarence N. Ahlem, Theodore M. Page, Dominick L. Auci, Michael R. Kennedy, Katia Mangano, Ferdinando Nicoletti, Yu Ge, Yujin Huang, Steven K. White, Sonia Villegas, Douglas Conrad, Angela Wang, Christopher L. Reading & James M. Frincke. (2011) Novel components of the human metabolome: The identification, characterization and anti-inflammatory activity of two 5-androstene tetrols. Steroids 76:1-2, pages 145-155.
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Peter L. BonatePeter L. Bonate. 2011. Pharmacokinetic-Pharmacodynamic Modeling and Simulation. Pharmacokinetic-Pharmacodynamic Modeling and Simulation 303 358 .
Hong Mei & Richard Morrison. 2009. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition. Using Mass Spectrometry for Drug Metabolism Studies, Second Edition 59 98 .
J English. 2006. Toxicological Testing Handbook. Toxicological Testing Handbook 79 107 .
Rakesh Dixit. 2006. Biological Concepts and Techniques in Toxicology. Biological Concepts and Techniques in Toxicology 117 160 .
D. K. Walker. (2004) The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development. British Journal of Clinical Pharmacology 58:6, pages 601-608.
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. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 175 188 .
D A Beatty & W W Piegorsch. (2016) Optimal statistical design for toxicokinetic studies. Statistical Methods in Medical Research 6:4, pages 359-376.
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Harry Mager & Gernot Göller. (1997) Comments on the Statistical Analysis of Toxicokinetic Studies. Drug Information Journal 31:2, pages 551-562.
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Mitchell N. Cayen. (2016) Considerations in the Design of Toxicokinetic Programs. Toxicologic Pathology 23:2, pages 148-157.
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Peter G. Welling. (2016) Differences Between Pharmacokinetics and Toxicokinetics. Toxicologic Pathology 23:2, pages 143-147.
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Dennis A. Smith. (1994) Design of drugs through a consideration of drug metabolism and pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 19:3, pages 193-199.
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Alastair Monro. (1994) Drug toxicokinetics: scope and limitations that arise from species differences in pharmacodynamic and carcinogenic responses. Journal of Pharmacokinetics and Biopharmaceutics 22:1, pages 41-57.
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Per Sjöberg. (2016) Toxicokinetics in Preclinical Safety Assessment—Views of the Swedish Medical Products Agency. Drug Information Journal 28:1, pages 151-157.
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David Case. (2016) Toxicokinetics: Some Definitions. Drug Information Journal 28:1, pages 145-149.
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C. Charuel. 1994. Use of Mechanistic Information in Risk Assessment. Use of Mechanistic Information in Risk Assessment 242 249 .
Tomoo Funaki, Hideko Onodera, Kotaro Ogawa, Shigeyasu Ichihara, Hideo Fukazawa & Isami Kuruma. (1993) Simultaneous determination of a new anticancer drug galocitabine and its metabolites in blood by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 11:4-5, pages 379-384.
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D. A. Smith. (1993) Integration of animal pharmacokinetic and pharmacodynamic data in drug safety assessment. European Journal of Drug Metabolism and Pharmacokinetics 18:1, pages 31-39.
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Heinz Nau. 1993. Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants. Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants 121 136 .
N.W. Spurling & P.F. Carey. (2016) Dose Selection for Toxicity Studies: A Protocol for Determining the Maximum Repeatable Dose. Human & Experimental Toxicology 11:6, pages 449-457.
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