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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 5
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Original Article

The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration I. Disposition and metabolic profiling

T. K. Gerding Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands; Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands
,
B. F. H. Drenth Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
,
H. J. Roosenstein Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
,
R. A. De Zeeuw Department of Toxicology, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
,
P. G. Tepper Department of Medicinal Chemistry, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
&
A. S. Horn Department of Medicinal Chemistry, State University, A. Deusinglaan 2, 9713 AW, Groningen, The Netherlands
Pages 515-524 | Received 16 Jan 1989, Accepted 28 Dec 1989, Published online: 27 Aug 2009

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Paul Tuite & Jennifer Riss. (2003) Recent developments in the pharmacological treatment of Parkinson’s disease. Expert Opinion on Investigational Drugs 12:8, pages 1335-1352.
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J. P. Mason, J. Caldwell & L. G. Dring. (1995) Metabolism of [propyl-3H]-8-hydroxy-2-(N,N-di-n-propylamino)tetralin in rat. Xenobiotica 25:1, pages 71-80.
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P. J. Swart, G. M. Bronner, A. P. Bruins, K. Ensing, P. G. Tepper & R. A. De Zeeuw. (1993) HPLC-UV Atmospheric Pressure Ionization Mass Spectrometry Determination of the Dopamine D2 Agonist N-0923 and Its Major Metabolites After Oxidative Metabolism by Rat-, Monkey-, and Human Liver Microsomes. Toxicology Methods 3:4, pages 279-290.
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T. K. Gerding, B. F. H. Drenth, R. A. De Zeeuw, P. G. Tepper & A. S. Horn. (1990) The metabolic fate of the dopamine agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin in rats after intravenous and oral administration II. Isolation and identification of metabolites. Xenobiotica 20:5, pages 525-536.
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Articles from other publishers (14)

Donald A. McAfee, Jonathan Hadgraft & Majella E. Lane. (2014) Rotigotine: The first new chemical entity for transdermal drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 88:3, pages 586-593.
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Izaak den Daas, Peter De Boer, Pieter G Tepper, Hans Rollema & Alan S Horn. (1991) Orally Active Carbamate Prodrugs of the Selective Dopamine Agonist N-0437: In-vivo Activities in the 6-OHDA Turning Model and In-vitro Activities. Journal of Pharmacy and Pharmacology 43:1, pages 11-16.
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Tove Johansson, Lars Weidolf & Ulrik Jurva. (2007) Mimicry of phase I drug metabolism – novel methods for metabolite characterization and synthesis. Rapid Communications in Mass Spectrometry 21:14, pages 2323-2331.
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Akhmad Kharis Nugroho, Gailing Li, Arne Grossklaus, Meindert Danhof & Joke A. Bouwstra. (2004) Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skin in vitro. Journal of Controlled Release 96:1, pages 159-167.
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Lloyd W Sumner, Pedro Mendes & Richard A Dixon. (2003) Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry 62:6, pages 817-836.
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Ulrik Jurva, H�kan V. Wikstr�m & Andries P. Bruins. (2000) In vitro mimicry of metabolic oxidation reactions by electrochemistry/mass spectrometry. Rapid Communications in Mass Spectrometry 14:6, pages 529-533.
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Peter Stjernlöf, Chiu-Hong Lin, Clas Sonesson, Kjell Svensson & Martin W. Smith. (1997) (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists. Bioorganic & Medicinal Chemistry Letters 7:21, pages 2759-2764.
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F Claudi, GM Cingolani, G Giorgioni, M Cardellini, F Amenta & C Polidori. (1995) New 2-pyridylethylamines with dopaminergic activity: Synthesis and radioligand-binding evaluation. European Journal of Medicinal Chemistry 30:5, pages 415-421.
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Denise R. Lowe Walters, William R. McConnell & Eugenio A. Cefali. (1994) Pharmacokinetic Study of (S)‐(−)‐2‐(N‐Propyl‐N‐(2‐thienylethyl)amino)‐5‐hydroxytetralin Infusion in Cynomolgus Monkeys. Journal of Pharmaceutical Sciences 83:5, pages 758-760.
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Paul A. Zavitsanos, Waheed Siddiqui & Michael Curtis. (2005) A high resolution gas chromatographic/mass spectrometric method for the determination of N‐0923 in human and monkey plasma. Rapid Communications in Mass Spectrometry 7:12, pages 1145-1149.
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P.J. Swart & R.A. De Zeeuw. (1993) Pharmacokinetics of the Dopamine D2 Agonist S(-)-2-(M-Propyl-M-2-thienylethylamino)-5-hydroxytetralin in Freely Moving Rats. Journal of Pharmaceutical Sciences 82:2, pages 200-203.
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Håkan Wikström. 1992. 185 216 .
P. J. Swart, F. G. A. Jansman, B. F. H. Drenth, R. A. de Zeeuw, D. Dijkstra & A. S. Horn. (2009) Impact of Structural Differences on the in Vitro Glucuronidation Kinetics of Potentially Dopaminergic Hydroxy‐2‐Aminotetralins and Naphthoxazines Using Rat and Human Liver Microsomes . Pharmacology & Toxicology 68:3, pages 215-219.
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Johanna M. Jansen, Izaak den Daas, Hans Rollema, Pieter J. Swart, Pieter G. Tepper, Jan B. de Vries & Alan S. Horn. (1991) Pharmacological profile of non-hydroxylated and ether derivatives of the potent D2-selective agonist N-0437. Naunyn-Schmiedeberg's Archives of Pharmacology 343:2, pages 134-142.
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