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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 6
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Original Article

Metabolic studies on pentachlorophenol (PCP) in rats

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Pages 573-582 | Received 04 Oct 1989, Accepted 30 Dec 1989, Published online: 27 Aug 2009

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M. Dubois, Y. Grosse, J. P. Thome, P. Kremers & A. Pfohl-Leszkowicz. (1997) Metabolic activation and DNA-adducts detection as biomarkers of chlorinated pesticide exposures. Biomarkers 2:1, pages 17-24.
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Po-Hsiung Lin, Suramya Waidyanatha & Stephen M. Rappaport. (1996) Investigation of liver binding of pentachlorophenol based upon measurement of protein adducts. Biomarkers 1:4, pages 232-243.
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Articles from other publishers (34)

Ruicheng Qi, Guoqiang Xiao, Jingjing Miao, Yueyao Zhou, Zeyuan Li, Zhiheng He, Ning Zhang, Aimin Song & Luqing Pan. (2023) Study on the toxic effects of sodium pentachlorophenol (PCP–Na) on razor clam (Sinonovacula constricta). Marine Environmental Research 183, pages 105845.
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Xiao-Meng Du, Bo Zhao, Qi Yang, Jia-Si Wang, Feng-Yang Xie, Hong-Yi Yu, Yue LiYu-Xin Ma & Wen-Juan Ruan. (2020) Dual-emissive dye@MOF composite for ratiometric detection and discrimination of two isomers of tetrachlorobenzenediol. New Journal of Chemistry 44:47, pages 20871-20877.
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Li Mao, Chun-Hua Huang, Jie Shao, Li Qin, Dan Xu, Bo Shao & Ben-Zhan Zhu. (2020) An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine. Free Radical Biology and Medicine 147, pages 150-158.
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Ivana Klopčič & Marija Sollner Dolenc. (2018) Chemicals and Drugs Forming Reactive Quinone and Quinone Imine Metabolites. Chemical Research in Toxicology 32:1, pages 1-34.
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Zixuan Liu, Wenjing Dong, Bingwei Yang, Lu Peng, Xiaomin Xia, Lanxiang Pu, Na Zhang, Erqun Song & Yang Song. (2018) Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis. Chemical Research in Toxicology 31:11, pages 1230-1239.
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Kai Yang, Zhi-Wei Fu, Yun-Feng Cao, Sai-Nan Li, Zuo Du, Xiao-Yu Sun, Yong-Zhe Liu, Kun Yang & Zhong-Ze Fang. (2018) New insights for risks of chlorophenols (CPs) exposure: Inhibition of UDP-glucuronosyltransferases (UGTs). Chemosphere 206, pages 9-16.
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Hsiu-Min Chen, Yu-Hsuan Lee & Ying-Jan Wang. (2015) ROS-Triggered Signaling Pathways Involved in the Cytotoxicity and Tumor Promotion Effects of Pentachlorophenol and Tetrachlorohydroquinone. Chemical Research in Toxicology 28:3, pages 339-350.
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Demei Xu, Lihua Hu, Xiaomin Xia, Jianbo Song, Lingrui Li, Erqun Song & Yang Song. (2014) Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid. Environmental Toxicology and Pharmacology 37:3, pages 1212-1220.
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Hui Dong, Demei Xu, Lihua Hu, Lingrui Li, Erqun Song & Yang Song. (2014) Evaluation of N-acetyl-cysteine against tetrachlorobenzoquinone-induced genotoxicity and oxidative stress in HepG2 cells. Food and Chemical Toxicology 64, pages 291-297.
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Etinosa O. Igbinosa, Emmanuel E. Odjadjare, Vincent N. Chigor, Isoken H. Igbinosa, Alexander O. Emoghene, Fredrick O. Ekhaise, Nicholas O. Igiehon & Omoruyi G. Idemudia. (2013) Toxicological Profile of Chlorophenols and Their Derivatives in the Environment: The Public Health Perspective. The Scientific World Journal 2013, pages 1-11.
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Darol E. Dodd, Linda J. Pluta, Mark A. Sochaski, Deborah A. Banas & Russell S. Thomas. (2012) Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats. Journal of Toxicology 2012, pages 1-10.
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Ben-Zhan Zhu, Jun-Ge Zhu, Rui-Mei Fan & Li Mao. 2011. 1 43 .
Yanjun Fang, Xianjun Gao, Jinmiao Zha, Baoan Ning, Xiaoli Li, Zhixian Gao & Fuhuan Chao. (2010) Identification of differential hepatic proteins in rare minnow (Gobiocypris rarus) exposed to pentachlorophenol (PCP) by proteomic analysis. Toxicology Letters 199:1, pages 69-79.
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Jaromir Michałowicz. (2010) Pentachlorophenol and its derivatives induce oxidative damage and morphological changes in human lymphocytes (in vitro). Archives of Toxicology 84:5, pages 379-387.
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Jaromir Michałowicz & Ireneusz Majsterek. (2010) Chlorophenols, chlorocatechols and chloroguaiacols induce DNA base oxidation in human lymphocytes (in vitro). Toxicology 268:3, pages 171-175.
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Jaromir Michałowicz & Paulina Sicińska. (2009) Chlorophenols and chlorocatechols induce apoptosis in human lymphocytes (in vitro). Toxicology Letters 191:2-3, pages 246-252.
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Ben-Zhan Zhu & Guo-Qiang Shan. (2009) Potential Mechanism for Pentachlorophenol-Induced Carcinogenicity: A Novel Mechanism for Metal-Independent Production of Hydroxyl Radicals. Chemical Research in Toxicology 22:6, pages 969-977.
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Jaume Folch, Marc Yeste-Velasco, Daniel Alvira, Aureli Vázquez de la Torre, Meritxell Bordas, Marta López, Francesc X. Sureda, Victor Rimbau, Antoni Camins & Mercè Pallàs. (2009) Evaluation of pathways involved in pentachlorophenol-induced apoptosis in rat neurons. NeuroToxicology 30:3, pages 451-458.
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Ying-Jan Wang, Ming-Chen Yang & Ming-Hsiung Pan. (2008) Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage. Food and Chemical Toxicology 46:12, pages 3739-3748.
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Hayrettin Ozan Gulcan, Yungang Liu & Michael W. Duffel. (2008) Pentachlorophenol and Other Chlorinated Phenols Are Substrates for Human Hydroxysteroid Sulfotransferase hSULT2A1. Chemical Research in Toxicology 21:8, pages 1503-1508.
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Richard A. Manderville & Annie Pfohl-Leszkowicz. 2006. 85 138 .
Anja Schreer, Cheryl Tinson, James P. Sherry & Kristin Schirmer. (2005) Application of Alamar blue/5-carboxyfluorescein diacetate acetoxymethyl ester as a noninvasive cell viability assay in primary hepatocytes from rainbow trout. Analytical Biochemistry 344:1, pages 76-85.
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William E Pepelko, David W Gaylor & Debdas Mukerjee. (2016) Comparative toxic potency ranking of chlorophenols. Toxicology and Industrial Health 21:3-4, pages 93-111.
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Yu‐Ping Lin, Ben‐Zhan Zhu, Ming‐Chen Yang, Balz Frei, Ming‐Hsiung Pan, Jen‐Kun Lin & Ying‐Jan Wang. (2004) Bcl‐2 overexpression inhibits tetrachlorohydroquinone‐induced apoptosis in NIH3T3 cells: A possible mechanism for tumor promotion. Molecular Carcinogenesis 40:1, pages 24-33.
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Wen‐Ching Chang, Jiiang‐Huei Jeng, Chi‐Chang Shieh, Yi‐Chang Tsai, Yuan‐Soon Ho, How‐Ran Guo, Hsin‐I Liu, Ching‐Chang Lee, Sheng‐Yow Ho & Ying‐Jan Wang. (2003) Skin tumor–promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD‐1 Mice. Molecular Carcinogenesis 36:4, pages 161-170.
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Ying-Jan Wang, Ching-Chang Lee, Wen-Ching Chang, Hung-Bin Liou & Yuan-Soon Ho. (2001) Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone. Toxicology Letters 122:2, pages 157-169.
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Chin-Hsiang Tsai, Po-Hsiung Lin, Suramya Waidyanatha & Stephen M Rappaport. (2001) Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver. Chemico-Biological Interactions 134:1, pages 55-71.
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Y.-J Wang, Y.-S Ho, J.-H Jeng, H.-J Su & C.-C Lee. (2000) Different cell death mechanisms and gene expression in human cells induced by pentachlorophenol and its major metabolite, tetrachlorohydroquinone. Chemico-Biological Interactions 128:3, pages 173-188.
Crossref
Ronald Eisler. 2000. Handbook of Chemical Risk Assessment. Handbook of Chemical Risk Assessment.
Irene Witte, Ben-Zhan Zhu, Aloys Lueken, Dino Magnani, Helge Stossberg & Mordechai Chevion. (2000) Protection by desferrioxamine and other hydroxamic acids against tetrachlorohydroquinone-induced cyto- and genotoxicity in human fibroblasts. Free Radical Biology and Medicine 28:5, pages 693-700.
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Po-Hsiung Lin, Suramya Waidyanatha, Gary M. Pollack & Stephen M. Rappaport. (1997) Dosimetry of Chlorinated Quinone Metabolites of Pentachlorophenol in the Livers of Rats and Mice Based upon Measurement of Protein Adducts. Toxicology and Applied Pharmacology 145:2, pages 399-408.
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Ying-Jan Wang, Yuan-Soon Ho, Shen-Way Chu, Heng-Jung Lien, Ting-Hsiu Liu & Jen-Kun Lin. (1997) Induction of glutathione depletion, p53 protein accumulation and cellular transformation by tetrachlorohydroquinone, a toxic metabolite of pentachlorophenol. Chemico-Biological Interactions 105:1, pages 1-16.
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Tomoyuki Ohe, Tadahiko Mashino & Masaaki Hirobe. (1995) Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1. Tetrahedron Letters 36:42, pages 7681-7684.
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J.K. Huwe. (1992) Artifact formation during gas chromatographic—mass spectrometric analysis of a methylsulfinyl-containing metabolite. Journal of Chromatography B: Biomedical Sciences and Applications 575:2, pages 287-288.
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