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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 7
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Original Article

Metabolism of illudin S, a toxic principle of Lampteromyces japonicus, by rat liver. I. Isolation and identification of cyclopropane ring-cleavage metabolites

K. Tanaka National Research Institute of Police Science, 6, Sanban-cho, Chiyoda-ku, Tokyo, 102, Japan
,
T. Inoue National Research Institute of Police Science, 6, Sanban-cho, Chiyoda-ku, Tokyo, 102, Japan
,
S. Kadota Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama, 930-01, Japan
&
T. Kikuchi Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama, 930-01, Japan
Pages 671-681 | Received 14 Sep 1989, Accepted 02 Mar 1990, Published online: 27 Aug 2009

Citations (15)

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Jun Abe, Hirohisa Nagahori, Hirokazu Tarui, Yoshitaka Tomigahara & Naohiko Isobe. (2018) Metabolism of metofluthrin in rats: I. Identification of metabolites. Xenobiotica 48:2, pages 157-169.
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K. Tanaka, T. Inoue, Y. Tezuka & T. Kikuchi. (1996) Metabolism of illudin S, a toxic substance of Lampteromyces japonicus: urinary excretion of mercapturic acids in rat. Xenobiotica 26:3, pages 347-354.
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K. Tanaka, T. Inoue, M. Kanai & T. Kikuchi. (1994) Metabolism of illudin S, a toxic substance of Lampteromyces japonicus. IV. Urinary excretion of an illudin S metabolite in rat. Xenobiotica 24:12, pages 1237-1243.
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K. Tanaka, T. Inoue, S. Kadota & T. Kikuchi. (1992) Metabolism by rat liver cytosol of illudin S, a toxic substance of Lampteromyces japonicus. II. Characterization of illudin S-metabolizing enzyme. Xenobiotica 22:1, pages 33-39.
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Articles from other publishers (11)

Seulah Lee, Jae Sik Yu, Seoung Rak Lee & Ki Hyun Kim. (2022) Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis. Natural Product Reports 39:3, pages 512-559.
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Philipp Le, Matthew B. Nodwell, Jürgen Eirich & Stephan A. Sieber. (2019) A Chemical Proteomic Analysis of Illudin‐Interacting Proteins. Chemistry – A European Journal 25:54, pages 12644-12651.
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Kathryn E. Pietsch, Paul M. van Midwoud, Peter W. Villalta & Shana J. Sturla. (2012) Quantification of Acylfulvene– and Illudin S–DNA Adducts in Cells with Variable Bioactivation Capacities. Chemical Research in Toxicology 26:1, pages 146-155.
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Marina Tanasova & Shana J. Sturla. (2012) Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents. Chemical Reviews 112:6, pages 3578-3610.
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Xiaodan Liu & Shana J. Sturla. (2009) Profiling patterns of glutathione reductase inhibition by the natural product illudin S and its acylfulvene analogues. Molecular BioSystems 5:9, pages 1013.
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Ryan A. Dick & Thomas W. Kensler. (2004) The Catalytic and Kinetic Mechanisms of NADPH-dependent Alkenal/one Oxidoreductase. Journal of Biological Chemistry 279:17, pages 17269-17277.
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Ryan A. Dick, Xiang Yu & Thomas W. Kensler. (2004) NADPH Alkenal/One Oxidoreductase Activity Determines Sensitivity of Cancer Cells to the Chemotherapeutic Alkylating Agent Irofulven. Clinical Cancer Research 10:4, pages 1492-1499.
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Nicolaas G.J Jaspers, Anja Raams, Michael J Kelner, Jessica M.Y Ng, Yukiko M Yamashita, Shiunichi Takeda, Trevor C McMorris & Jan H.J Hoeijmakers. (2002) Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair 1:12, pages 1027-1038.
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Trevor C. McMorris, Anissa N. Elayadi, Jian Yu & Michael J. Kelner. (1999) Metabolism of antitumor acylfulvene by rat liver cytosol. Biochemical Pharmacology 57:1, pages 83-88.
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K. Tanaka, S. Miyasaka & T. Inoue. (2016) Histopathological effects of Illudin S, a toxic substance of poisonous mushroom, in rat. Human & Experimental Toxicology 15:4, pages 289-293.
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Michael J. Kelner, Trevor C. McMorris, Leita Estes, Mary Rutherford, Mark Montoya, Jill Goldstein, Kyra Samson, Robin Starr & Raymond Taetle. (1994) Characterization of illudin S sensitivity in DNA repair-deficient chinese hamster cells. Biochemical Pharmacology 48:2, pages 403-409.
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