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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 7
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Original Article

Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine

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Pages 727-738 | Received 23 Oct 1989, Accepted 10 Jan 1990, Published online: 27 Aug 2009

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Read on this site (4)

Ursula Breyer‐Pfaff. (2004) The Metabolic Fate of Amitriptyline, Nortriptyline and Amitriptylinoxide in Man. Drug Metabolism Reviews 36:3-4, pages 723-746.
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H. Luo, E. M. Hawes, G. McKay, E. D. Korchinski & K. K. Midha. (1995) N+ -Glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs. Xenobiotica 25:3, pages 291-301.
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H. Luo, E. M. Hawes, G. McKay, E. D. Korchinski & K. K. Midha. (1991) N+-Glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans. Xenobiotica 21:10, pages 1281-1288.
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Articles from other publishers (17)

Yue Pan. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 278 302 .
Xin Zhou, Chang Chen, Fangrong Zhang, Yang Zhang, Yuling Feng, Hui Ouyang, Yong Xu & Hongliang Jiang. (2016) Metabolism and bioactivation of the tricyclic antidepressant amitriptyline in human liver microsomes and human urine. Bioanalysis 8:13, pages 1365-1381.
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Emma-Claire ElliottSophie L. ReganJames L. MaggsElizabeth R. BowkettLaura J. ParryDominic P. WilliamsB. Kevin ParkAndrew V. Stachulski. (2012) Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. Journal of Medicinal Chemistry 55:22, pages 9773-9784.
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Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong & Xiaoyan Chen. (2012) Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N + -Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9 . Drug Metabolism and Disposition 40:3, pages 556-567.
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Henriette Kold Uldam, Martin Juhl, Henrik Pedersen & Lars Dalgaard. (2011) Biosynthesis and Identification of an N -Oxide/ N -Glucuronide Metabolite and First Synthesis of an N-O -Glucuronide Metabolite of Lu AA21004 . Drug Metabolism and Disposition 39:12, pages 2264-2274.
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Dorothee Fischer & Ursula Breyer-Pfaff. (1995) Comparison of Procedures for Measuring the Quaternary N -Glucuronides of Amitriptyline and Diphenhydramine in Human Urine with and without Hydrolysis . Journal of Pharmacy and Pharmacology 47:6, pages 534-538.
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Nuggehally R. Srinivas & Ramesh Mullangi. (2011) An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerations. Biomedical Chromatography 25:1-2, pages 65-81.
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Eva M. Lenz, Michael Spear, C. Drake, Christopher R.J. Pollard, Michelle Ward, Timothy Schulz-Utermoehl & Mike Harrison. (2010) Characterisation and identification of the human N+-glucuronide metabolite of cediranib. Journal of Pharmaceutical and Biomedical Analysis 53:3, pages 526-536.
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Ming-rong QIAN & Su ZENG. (2006) Biosynthesis of imipramine glucuronide and characterization of imipramine glucuronidation catalyzed by recombinant UGT1A41. Acta Pharmacologica Sinica 27:5, pages 623-628.
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Verawan Uchaipichat, Leanne K. Winner, Peter I. Mackenzie, David J. Elliot, J Andrew Williams & John O. Miners. (2006) Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation . British Journal of Clinical Pharmacology 61:4, pages 427-439.
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I Kowalczyk, E.M Hawes & G McKay. (2000) Stability and enzymatic hydrolysis of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine-implications for analysis. Journal of Pharmaceutical and Biomedical Analysis 22:5, pages 803-811.
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Xing-Fang Li, Chung-Sheng Liu, Pieter Roos, Eugene B. Hansen, Carl E. Cerniglia & Norman J. Dovichi. (1998) Nonaqueous capillary electrophoretic separation and thermo-optical absorbance detection of five tricyclic antidepressants and metabolism of amitriptyline byCunninghamella elegans. Electrophoresis 19:18, pages 3178-3182.
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Robert L Hagan, James M Ramos Jr & Peyton M Jacob III. (1997) Increasing urinary cotinine concentrations at elevated temperatures: the role of conjugated metabolites. Journal of Pharmaceutical and Biomedical Analysis 16:2, pages 191-197.
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B. Lu, M. Koimur & D. Westerlund. (1997) Separation of phenolic compounds and corresponding glucuronides by coupled-column micellar reversed-phase liquid chromatography. Chromatographia 46:1-2, pages 72-78.
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D. Fischer & U. Breyer-Pfaff. (1997) Variability of diphenhydramine N-glucuronidation in healthy subjects. European Journal of Drug Metabolism and Pharmacokinetics 22:2, pages 151-154.
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Keizo Sato, Takeshi Kumazawa & Yoshinao Katsumata. (1994) On-line high-performance liquid chromatography-fast atom bombardment mass spectrometry in forensic analysis. Journal of Chromatography A 674:1-2, pages 127-145.
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B. Becher, W. Fischer, Z. Taneri, E. Scholz, W. E. Müller & U. Breyer-Pfaff. (1992) Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy. Psychopharmacology 106:3, pages 303-310.
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