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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 8
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Original Article

Mechanism of formation of 6-amino-5-(N-methylformylamino)-1-methyluracil and 3,7-dimethyluric acid from theobromine in the rat in vitro: involvement of cytochrome P-450 and a cellular thiol

A. Lelo Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, 5042, Australia
,
D. J. Birkett Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, 5042, Australia
&
J. O. Miners Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, 5042, Australia
Pages 823-833 | Received 05 Apr 1988, Accepted 21 Apr 1990, Published online: 27 Aug 2009

Citations (5)

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F. Berthou, B. Guillois, C. Riche, Y. Dreano, E. Jacqz-Aigrain & P. H. Beaune. (1992) Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes. Xenobiotica 22:6, pages 671-680.
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Articles from other publishers (4)

Simonetta Camandola, Natalie Plick & Mark P. Mattson. (2018) Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease. Neurochemical Research 44:1, pages 214-227.
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Bertil B. FredholmMaurice J. Arnaud. 2011. Methylxanthines. Methylxanthines 33 91 .
Simon Gates & John O. Miners. (2001) Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. British Journal of Clinical Pharmacology 47:3, pages 299-305.
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John O. Miners & Donald J. Birkett. (1996) The use of caffeine as a metabolic probe for human drug metabolizing enzymes. General Pharmacology: The Vascular System 27:2, pages 245-249.
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