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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 9
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Original Article

One-electron reduction of mitomycin c by rat liver: Role of cytochrome P-450 and NADPH-cytochrome P-450 reductase

R. M. Vromans Department of Pharmacochemistry (Molecular Toxicology), Free University, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands; Glaxo B.V., Nieuwegein, The Netherlands
,
R. van de Straat Department of Pharmacochemistry (Molecular Toxicology), Free University, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands; Procter & Gamble European Technical Center, Strombeek-Bever, Belgium
,
M. Groeneveld Department of Pharmacochemistry (Molecular Toxicology), Free University, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands
&
N. P. E. Vermeulen Department of Pharmacochemistry (Molecular Toxicology), Free University, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands
Pages 967-978 | Received 31 May 1989, Accepted 20 Dec 1989, Published online: 27 Aug 2009

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Haydar Çelik & Emel Arinç. (2013) Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4. Xenobiotica 43:3, pages 263-275.
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Marc Maliepaard, Nico J. De Mol, Lambert H.M. Janssen, Arnold r. Goeptar, Johan M. Te Koppele, Nico P.E. Vermeulen, Willem Verboom & David N. Reinhoudt. (1995) Reduction of Antitumour Mitosenes in Non-Aqueous and Aqueous Environment. An Electron Spin Resonance and Cyclic Voltammetry Study. Free Radical Research 22:2, pages 109-121.
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Arnold R. Goeptar, Heleen Scheerens & Nico P. E. Vermeulen. (1995) Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 25:1, pages 25-65.
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Articles from other publishers (13)

Laurent Gate & Kenneth D. Tew. 2011. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures 61 85 .
Yun Wang, Joshua P. Gray, Vladimir Mishin, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2010) Distinct Roles of Cytochrome P 450 Reductase in Mitomycin c Redox Cycling and Cytotoxicity . Molecular Cancer Therapeutics 9:6, pages 1852-1863.
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Octávia Monteiro Gil, Nuno Guerreiro Oliveira, António Sebastião Rodrigues, António Laires, Teresa Cruz Ferreira, Edward Limbert & José Rueff. (2002) Possible transient adaptive response to mitomycin C in peripheral lymphocytes from thyroid cancer patients after iodine‐131 therapy. International Journal of Cancer 102:6, pages 556-561.
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Koji Furuno, Tatsuya Suetsugu, Kimi Shimomichi, Yasuto Tsuruta & Narumi Sugihara. (1998) Lipid Peroxidation Induced by Adriamycin in Linolenic Acid-Loaded Cultured Hepatocytes. Pharmacology & Toxicology 83:4, pages 176-182.
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Rui Ferreira, Fátima Candeias, Fátima Simões, José Nascimento & J. Cruz Morais. (1997) Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar Rat. Journal of Ethnopharmacology 58:1, pages 21-30.
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Alexander E. MacCubbin, Anuradha Mudipalli, Srikanth S. Nadadur, Noreen Ersing & Hira L. Gurtoo. (1997) Mutations induced in a shuttle vector plasmid exposed to monofunctionally activated mitomycin C. Environmental and Molecular Mutagenesis 29:2, pages 143-151.
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Helen M. Barham & Ian J. Stratford. (1996) Enzymology of the reduction of the novel fused pyrazine mono-N-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase. Biochemical Pharmacology 51:6, pages 829-837.
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Arnold R. Goeptar, Johan M. te Koppele, Hansruedi R. Glatt, Ed J. Groot, Albrecht Seidel, Martine Barrenscheen, Catherine Wölfel, Johannes Doehmer & Nico P.E. Vermeulen. (1995) The cytotoxicity of mitomycin C and Adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes. Chemico-Biological Interactions 97:2, pages 149-168.
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Song J. Li, E.Hazel Rodgers & M.Helen Grant. (1995) The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents. Chemico-Biological Interactions 97:2, pages 101-118.
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Osamu Hirai, Youichi Miyamae, Yuko Hattori, Miyuki Takashima, Atsushi Miyamoto, Kazuyo Zaizen & Yasuhiro Mine. (1994) Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent. Mutation Research Letters 324:1-2, pages 43-50.
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Jeffrey Cummings, Lucy Allan & John F. Smyth. (1994) Encapsulation of mitomycin C in albumin microspheres markedly alters pharmacokinetics, drug quinone reduction in tumour tissue and antitumour activity. Biochemical Pharmacology 47:8, pages 1345-1356.
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Arnold R. Goeptar, Johan M. Te Koppele, Etienne P.A. Neve & Nico P.E. Vermeulen. (1992) Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate. Chemico-Biological Interactions 83:3, pages 249-269.
Crossref
Arnold R. Goeptar, Johan M. te Koppele, Jan M.S. van Maanen, Clema E.M. Zoetemelk & Nico P.E. Vermeulen. (1992) One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450. Biochemical Pharmacology 43:2, pages 343-352.
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