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Xenobiotica
the fate of foreign compounds in biological systems
Volume 20, 1990 - Issue 2
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Research Article

Identification of glucose conjugates as major urinary metabolites of cannabidiol in the dog

E. Samara Department of Pharmacy, The Hebrew University of Jerusalem, PO Box 12065, Jerusalem, 91120, Israel
,
M. Bialer Department of Pharmacy, The Hebrew University of Jerusalem, PO Box 12065, Jerusalem, 91120, Israel
&
D. J. Harvey University Department of Pharmacology, South Parks Road, Oxford, OX1 3QT, UK
Pages 177-183 | Received 03 May 1989, Accepted 05 Sep 1989, Published online: 22 Sep 2008

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Sunil Sarda, Chris Page, Kathryn Pickup, Timothy Schulz-Utermoehl & Ian Wilson. (2012) Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry. Xenobiotica 42:2, pages 179-194.
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H. Major, J. Castro-Perez, J. K. Nicholson & I. D. Wilson. (2003) Detection of mono- and di-hexoses as metabolites of 4-bromoaniline using HPLC-TOF-MS/MS. Xenobiotica 33:8, pages 855-869.
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G. L. LARSEN. (1998) Intermediary metabolism of pentachloronitrobenzene in the control and germfree rat and rat with cannulated bile ducts. Xenobiotica 28:10, pages 973-984.
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Articles from other publishers (14)

Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury & Xiaochun Zhu. (2020) Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver. Drug Metabolism and Disposition 48:10, pages 934-943.
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Patricia Golombek, Marco Müller, Ines Barthlott, Constanze Sproll & Dirk W. Lachenmeier. (2020) Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature. Toxics 8:2, pages 41.
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Erik A. Levinsohn & Kevin P. Hill. (2020) Clinical uses of cannabis and cannabinoids in the United States. Journal of the Neurological Sciences 411, pages 116717.
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Simona Pisanti, Anna Maria Malfitano, Elena Ciaglia, Anna Lamberti, Roberta Ranieri, Gaia Cuomo, Mario Abate, Giorgio Faggiana, Maria Chiara Proto, Donatella Fiore, Chiara Laezza & Maurizio Bifulco. (2017) Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacology & Therapeutics 175, pages 133-150.
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M. Mecha, A. Feliú, F.J. Carrillo-Salinas & C. Guaza. 2017. Handbook of Cannabis and Related Pathologies. Handbook of Cannabis and Related Pathologies 893 904 .
István UjváryLumír Hanuš. (2016) Human Metabolites of Cannabidiol: A Review on Their Formation, Biological Activity, and Relevance in Therapy. Cannabis and Cannabinoid Research 1:1, pages 90-101.
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Teresa Iuvone, Giuseppe Esposito, Daniele De Filippis, Caterina Scuderi & Luca Steardo. (2009) Cannabidiol: A Promising Drug for Neurodegenerative Disorders?. CNS Neuroscience & Therapeutics 15:1, pages 65-75.
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Bernard Testa & Stefanie D. Krämer. (2008) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 5:11, pages 2171-2336.
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David J. Harvey. 1999. Marihuana and Medicine. Marihuana and Medicine 91 103 .
D.J. Harvey, E. Samara & R. Mechoulam. (1991) Comparative metabolism of cannabidiol in dog, rat and man. Pharmacology Biochemistry and Behavior 40:3, pages 523-532.
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E. Samara, M. Bialer & D. J. Harvey. (1991) Metabolism of cannabidiol by the rat. European Journal of Drug Metabolism and Pharmacokinetics 16:4, pages 305-313.
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William H. Soine, Phyllis J. Soine & Terry M. England. (1991) Barbital N-glucoside is not detected as a urinary excretion product of barbital in humans. Journal of Pharmaceutical and Biomedical Analysis 9:9, pages 747-752.
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D.J. Harvey, E. Samara & R. Mechoulam. (1991) Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography—mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 562:1-2, pages 299-322.
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Emil Samara, Meir Bialer & David J. Harvey. (2006) Pharmacokinetics of urinary metabolites of cannabidiol in the dog. Biopharmaceutics & Drug Disposition 11:9, pages 785-795.
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