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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 1
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Original Article

Cytochrome P-450 spin state and leakiness of the monooxygenase pathway

J. Blanck Department of Biocatalysis and Heme Catalysis, Central Institute of Molecular Biology, Academy of Sciences of the GDR, 1115, Berlin, Robert-Roessle-Strasse 10GDR
,
O. Ristau Department of Biocatalysis and Heme Catalysis, Central Institute of Molecular Biology, Academy of Sciences of the GDR, 1115, Berlin, Robert-Roessle-Strasse 10GDR
,
A. A. Zhukov Department of Biochemistry, Medico-Biological Faculty, 2nd Moscow Medical Institute, 117437, Moscow, USSR
,
A. I. Archakov Department of Biochemistry, Medico-Biological Faculty, 2nd Moscow Medical Institute, 117437, Moscow, USSR
,
H. Rein Department of Biocatalysis and Heme Catalysis, Central Institute of Molecular Biology, Academy of Sciences of the GDR, 1115, Berlin, Robert-Roessle-Strasse 10GDR
&
K. Ruckpaul Department of Biocatalysis and Heme Catalysis, Central Institute of Molecular Biology, Academy of Sciences of the GDR, 1115, Berlin, Robert-Roessle-Strasse 10GDR
Pages 121-135 | Received 31 Jan 1990, Accepted 04 Jul 1990, Published online: 27 Aug 2009

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Humaira Aziz Sawal, Kashif Asghar, Matthias Bureik & Nasir Jalal. (2017) Bystander signaling via oxidative metabolism. OncoTargets and Therapy 10, pages 3925-3940.
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B. Sid, J. Verrax & P. B. Calderon. (2013) Role of oxidative stress in the pathogenesis of alcohol-induced liver disease. Free Radical Research 47:11, pages 894-904.
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Harshica Fernando, Jessica A. O. Rumfeldt, Nadezhda Y. Davydova, James R. Halpert & Dmitri R. Davydov. (2011) Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity. Xenobiotica 41:4, pages 281-289.
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Peter Hlavica. (2002) N-OXIDATIVE TRANSFORMATION OF FREE AND N-SUBSTITUTED AMINE FUNCTIONS BY CYTOCHROME P450 AS MEANS OF BIOACTIVATION AND DETOXICATION. Drug Metabolism Reviews 34:3, pages 451-477.
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David F. V. Lewis & John M. Pratt. (1998) The P450 Catalytic Cycle and Oxygenation Mechanism. Drug Metabolism Reviews 30:4, pages 739-786.
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Peter Hlavica. (1994) Regulatory Mechanisms in the Activation of Nitrogenous Compounds by Mammalian Cytochrome P-450 Isozymes. Drug Metabolism Reviews 26:1-2, pages 325-348.
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Lisa K. Morlock, Dominique Böttcher & Uwe T. Bornscheuer. (2017) Simultaneous detection of NADPH consumption and H2O2 production using the Ampliflu™ Red assay for screening of P450 activities and uncoupling. Applied Microbiology and Biotechnology 102:2, pages 985-994.
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A.I. Cederbaum. 2017. Liver Pathophysiology. Liver Pathophysiology 401 419 .
M. Tarocchi & A. Galli. 2017. Liver Pathophysiology. Liver Pathophysiology 279 287 .
Arthur I. Cederbaum. (2015) Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications. Redox Biology 4, pages 60-73.
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Francesco De Matteis, David P. Ballou, Minor J. Coon, Ronald W. Estabrook & Donovan C. Haines. (2012) Peroxidase-like activity of uncoupled cytochrome P450. Biochemical Pharmacology 84:3, pages 374-382.
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Arthur I. Cederbaum, Lili Yang, Xiaodong Wang & Defeng Wu. (2012) CYP2E1 Sensitizes the Liver to LPS- and TNF α -Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases . International Journal of Hepatology 2012, pages 1-19.
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Roberto Gambino, Giovanni MussoMaurizio Cassader. (2011) Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities. Antioxidants & Redox Signaling 15:5, pages 1325-1365.
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Aparajita Dey & S. Mathan Kumar. (2011) Cytochrome P450 2E1 and hyperglycemia-induced liver injury. Cell Biology and Toxicology 27:4, pages 285-310.
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Elena V. Sineva & Dmitri R. Davydov. (2010) Cytochrome P450 from Photobacterium profundum SS9, a Piezophilic Bacterium, Exhibits a Tightened Control of Water Access to the Active Site . Biochemistry 49:50, pages 10636-10646.
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Yongke Lu & Arthur I. Cederbaum. (2009) CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes & Nutrition 5:2, pages 149-167.
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Arthur I. Cederbaum, Yongke Lu & Defeng Wu. (2009) Role of oxidative stress in alcohol-induced liver injury. Archives of Toxicology 83:6, pages 519-548.
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Yongke Lu & Arthur I. Cederbaum. (2008) CYP2E1 and oxidative liver injury by alcohol. Free Radical Biology and Medicine 44:5, pages 723-738.
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Arthur I. Cederbaum. 2008. Advances in Bioactivation Research. Advances in Bioactivation Research 1 36 .
Ilia G. Denisov, Yelena V. Grinkova, Mark A. McLean & Stephen G. Sligar. (2007) The One-electron Autoxidation of Human Cytochrome P450 3A4. Journal of Biological Chemistry 282:37, pages 26865-26873.
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Harshica Fernando, Dmitri R. Davydov, Christopher C. Chin & James R. Halpert. (2007) Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Archives of Biochemistry and Biophysics 460:1, pages 129-140.
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Francesco De Matteis, Gwyn A. Lord, Chang Kee Lim & Nicoletta Pons. (2006) Bilirubin degradation by uncoupled cytochrome P450. Comparison with a chemical oxidation system and characterization of the products by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 20:8, pages 1209-1217.
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Dmitri R. Davydov, Alexandra E. Botchkareva, Nadezhda E. Davydova & James R. Halpert. (2005) Resolution of Two Substrate-Binding Sites in an Engineered Cytochrome P450eryF Bearing a Fluorescent Probe. Biophysical Journal 89:1, pages 418-432.
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Christiane Jung, Sergey A Kozin, Bernard Canny, Jean-Claude Chervin & Gaston Hui Bon Hoa. (2003) Compressibility and uncoupling of cytochrome P450cam: high pressure FTIR and activity studies. Biochemical and Biophysical Research Communications 312:1, pages 197-203.
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James R Reed & Paul F Hollenberg. (2003) Examining the mechanism of stimulation of cytochrome P450 by cytochrome b5: the effect of cytochrome b5 on the interaction between cytochrome P450 2B4 and P450 reductase. Journal of Inorganic Biochemistry 97:3, pages 265-275.
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Nicoletta Pons, Sandra Pipino & Francesco De Matteis. (2003) Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Biochemical Pharmacology 66:3, pages 405-414.
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James R. Reed & Paul F. Hollenberg. (2003) Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5. Journal of Inorganic Biochemistry 93:3-4, pages 152-160.
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Francesco De Matteis, Sally J. Dawson, Nicoletta Pons & Sandra Pipino. (2002) Bilirubin and uroporphyrinogen oxidation by induced cytochrome P4501A and cytochrome P4502B. Biochemical Pharmacology 63:4, pages 615-624.
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Peter Hlavica & David F. V. Lewis. (2008) Allosteric phenomena in cytochrome P450‐catalyzed monooxygenations. European Journal of Biochemistry 268:18, pages 4817-4832.
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David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450 164 210 .
David F.V. Lewis & Peter Hlavica. (2000) Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1460:2-3, pages 353-374.
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Wolfgang Klinger. 1995. Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Molecular Aspects of Oxidative Drug Metabolizing Enzymes 515 532 .
M. Ingelman-Sundberg, A. Zhukov, S. Mkrtchian & E. Eliasson. 1994. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research. Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research 195 211 .
H. Kappus. 1993. Cytochrome P450. Cytochrome P450 145 154 .
H. Rein & C. Jung. 1993. Cytochrome P450. Cytochrome P450 105 122 .
H. Rein, O. Ristau, J. Blanck & K. Ruckpaul. 1992. Free Radicals and the Liver. Free Radicals and the Liver 29 35 .

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