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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 3
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Research Article

Metabolism of pravastatin sodium in isolated rat hepatocytes. II. Structure elucidation of the metabolites by n.m.r. spectroscopy

T. Nakamura Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
,
K. Yoda Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
,
H. Kuwano Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
,
K. Miyaguchi Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
,
S. Muramatsu Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
,
H. Takahagi Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
&
T. Kinoshita Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd., 2-58, Hiromachi 1-Chome, Shinagawa-ku, Tokyo, 140, Japan
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Pages 277-293 | Received 16 Jan 1990, Accepted 09 Nov 1990, Published online: 22 Sep 2008

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S. Muramatsu, K. Miyaguchi, H. Iwabuchi, Y. Matsushita, T. Nakamura, T. Kinoshita, M. Tanaka & H. Takahagi. (1992) Metabolism of pravastatin sodium in isolated rat hepatocytes. I. Glutathione conjugate formation reaction. Xenobiotica 22:5, pages 487-498.
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Articles from other publishers (5)

Abdullah A. Al-Badr & Gamal A.E. Mostafa. 2014. 433 513 .
Angela Wehr. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 6 .
Raju Subramanian, Xiaojun Fang & Thomayant Prueksaritanont. (2002) Structural Characterization of in Vivo Rat Glutathione Adducts and a Hydroxylated Metabolite of Simvastatin Hydroxy Acid. Drug Metabolism and Disposition 30:3, pages 225-230.
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G.E. Stokker. (1994) Synthesis of the 3′(S)-hydroxy derivative of simvastatin. Bioorganic & Medicinal Chemistry Letters 4:14, pages 1767-1770.
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T. Komai, K. Kawai, T. Tokui, Y. Tokui, C. Kuroiwa, E. Shigehara & M. Tanaka. (1992) Disposition and metabolism of pravastatin sodium in rats, dogs and monkeys. European Journal of Drug Metabolism and Pharmacokinetics 17:2, pages 103-113.
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