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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 3
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Research Article

Metabolism of minaprine in human and animal hepatocytes and liver microsomes—prediction of metabolism in vivo

E. Lacarelle INSERM U 278, Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385, Marseille, Cedex 5, France
,
F. Marre INSERM U 278, Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385, Marseille, Cedex 5, France
,
A. Durand Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques, CHU Timone, 13385, Marseille, Cedex, 5, France
,
H. Davi Sanofi Recherche, 371 Rue du Professeur Joseph Blayac, 234082, Montpellier, Cedex 5, France
&
R. Rahmani INSERM U 278, Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385, Marseille, Cedex 5, France
Pages 317-329 | Received 14 Feb 1990, Accepted 18 Sep 1990, Published online: 22 Sep 2008

Citations (13)

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M. K. BAYLISS. (1999) Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man. Xenobiotica 29:3, pages 253-268.
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F. Salmon & W. Kohl. (1996) Use of fresh and cryopreserved hepatocytes to study the metabolism of pesticides in food-producing animals and rats. Xenobiotica 26:8, pages 803-811.
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M. Spatzenegger & W. Jaeger. (1995) Clinical Importance of Hepatic Cytochrome P450 in Drug Metabolism. Drug Metabolism Reviews 27:3, pages 397-417.
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G. W. Sandker, R. M. E. Vos, L. P. C. Delbressine, M. J. H. Slooff, D. K. F. Meijer & G. M. M. Groothuis. (1994) Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: Analysis of interspecies variability and comparison with metabolism in vivo. Xenobiotica 24:2, pages 143-155.
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K. Lee, Y. Vandenberghe, M. Herin, R. Cavalier, D. Beck, A. Li, N. Verbeke, M. Lesne & J. Roba. (1994) Comparative metabolism of SC-42867 and SC-51089, two PGE2 antagonists, in rat and human hepatocyte cultures. Xenobiotica 24:1, pages 25-36.
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B. Vallès, Ph. Coassolo, G. de Sousa, C. Aubert & R. Rahmani. (1993) In vitro hepatic biotransformation of moclobemide (Ro 11-1163) in man and rat. Xenobiotica 23:10, pages 1101-1111.
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Articles from other publishers (7)

C. Delescluse, N. Ledirac, G. de Sousa, M. Pralavorio, D. Botta-Fridlund, Y. Letreut & R. Rahmani. (1997) Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types. Toxicology in Vitro 11:5, pages 443-450.
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P. Olinga, D.K.F. Meijer, M.J.H. Slooff & G.M.M. Groothuis. (1997) Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. Toxicology in Vitro 12:1, pages 77-100.
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ANDRÉ GUILLOUZO. 1997. In Vitro Methods in Pharmaceutical Research. In Vitro Methods in Pharmaceutical Research 411 431 .
G. de Sousa, N. Florence, B. Vallès, P. Coassolo & R. Rahmani. (1995) Relationships betweenin vitro andin vivo biotransformation of drugs in humans and animals: pharmaco-toxicological consequences. Cell Biology and Toxicology 11:3-4, pages 147-153.
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André Guillouzo, Fabrice Morel, Olivier Fardel & Bernard Meunier. (1993) Use of human hepatocyte cultures for drug metabolism studies. Toxicology 82:1-3, pages 209-219.
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Dennis A. Smith & Barry C. Jones. (1992) Speculations on the Substrate Structure-Activity Relationship (SSAR) of cytochrome P450 enzymes. Biochemical Pharmacology 44:11, pages 2089-2098.
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G. de Sousa, M. Dou, D. Barbe, B. Lacarelle, M. Placidi & R. Rahmani. (1991) Freshly isolated or cryopreserved human hepatocytes in primary culture: Influence of drug metabolism on hepatotoxicity. Toxicology in Vitro 5:5-6, pages 483-486.
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