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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
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Original Article

Sex difference in the stereoselective metabolism of a new dihydropyridine calcium channel blocker, in rat studies in vivo and in vitro

F. Takayama Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., 9-3 2-chome Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
K. Saito Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., 9-3 2-chome Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
Y. Ishii Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., 9-3 2-chome Shimomeguro, Meguro-ku, Tokyo, 153, Japan
,
K. Shiratori Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., 9-3 2-chome Shimomeguro, Meguro-ku, Tokyo, 153, Japan
&
M. Ohtawa Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., 9-3 2-chome Shimomeguro, Meguro-ku, Tokyo, 153, Japan
Pages 557-568 | Received 26 Mar 1990, Accepted 23 Jul 1990, Published online: 27 Aug 2009

Citations (5)

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Read on this site (1)

H. KOBAYASHI*S. KOBAYASHI. (1998) Absorption, distribution, metabolism and excretion of 14C-labelled enantiomers of the calcium channel blocker benidipine after oral administration to rat. Xenobiotica 28:2, pages 179-197.
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Articles from other publishers (4)

Nobuo Inotsume & Masahiro Nakano. (2002) Stereoselective determination and pharmacokinetics of dihydropyridines: an updated review. Journal of Biochemical and Biophysical Methods 54:1-3, pages 255-274.
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Yuichi Hattori & Morio Kanno. (2007) Pharmacology and Therapeutic Potential of Lemildipine, a Highly Vasculoselective Dihydropyridine Derivative with Slow Onset and Long Duration of Action. Cardiovascular Drug Reviews 14:4, pages 317-333.
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Takashi Sakamoto, Yumi Ohtake, Motofumi Itoh, Shigeru Tabata, Takeo Kuriki & Kazuo Uno. (2005) Determination of felodipine enantiomers using chiral stationary phase liquid chromatography and gas chromatography/mass spectrometry, and the study of their pharmacokinetic profiles in human and dog. Biomedical Chromatography 7:2, pages 99-103.
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M. Ohtawa & N. Uchiyama. (1992) Sex difference in metabolism of simvastatin by rat hepatic microsomes. European Journal of Drug Metabolism and Pharmacokinetics 17:3, pages 175-181.
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