Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
20
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Disposition and metabolism of acetylcholinesterase reactivators 2PAM-I, TMB4 and R665 in rats submitted to organophosphate poisoning

, , , , , , , & show all
Pages 583-595 | Received 15 May 1990, Accepted 23 Nov 1990, Published online: 27 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Victor A. Voicu, Andrei Valentin Medvedovici, Koichi Sakurada, Hikoto Ohta, Flavian Ștefan Rădulescu & Dalia Simona Miron. (2016) The forgotten or underestimated relevance of biopharmaceutical-based assessments for the oral absorption studies of oxime reactivators. Expert Opinion on Drug Metabolism & Toxicology 12:7, pages 743-752.
Read now

Articles from other publishers (15)

Jana Zdarova Karasova, Jiri Kassa, Vendula Hepnarova, Jaroslav Pejchal, Lucie Junova, Rudolf Andrys, David Malinak, Petr Bzonek, Zuzana Kohoutova & Kamil Musilek. (2022) Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870. Food and Chemical Toxicology 167, pages 113236.
Crossref
Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, Gordana Mendaš, Vedran Micek, Nikolina Maček Hrvat, Maja Katalinić, Anissa Braïki, Ludovic Jean, Pierre-Yves Renard, Vesna Gabelica Marković & Zrinka Kovarik. (2020) Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. ACS Chemical Neuroscience 11:7, pages 1072-1084.
Crossref
Sabine Reimann, Tobias Schneider, Pia Welker, Falko Neumann, Kai Licha, Gundula Schulze-Tanzil, Wolfgang Wagermaier, Peter Fratzl & Rainer Haag. (2017) Dendritic polyglycerol anions for the selective targeting of native and inflamed articular cartilage. Journal of Materials Chemistry B 5:24, pages 4754-4767.
Crossref
Teresa R. Sterner, Christopher D. Ruark, Tammie R. Covington, Kyung O. Yu & Jeffery M. Gearhart. (2013) A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data. Archives of Toxicology 87:4, pages 661-680.
Crossref
Harald John, Michael Eddleston, R. Eddie Clutton, Franz Worek & Horst Thiermann. (2012) Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig. Drug Testing and Analysis 4:3-4, pages 169-178.
Crossref
Harald John & Marc-Michael Blum. (2012) Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM). Drug Testing and Analysis 4:3-4, pages 179-193.
Crossref
Elisabeth Miot-Noirault, François Gouin, Aurélien Vidal, Maryse Rapp, Jean Maublant, Serge Askienazy, Jean-Michel Chezal, Dominique Heymann, Françoise Redini & Nicole Moins. (2009) First Preclinical Imaging of Primary Cartilage Neoplasm and Its Local Recurrence Using 99m Tc-NTP 15-5 Radiotracer . Journal of Nuclear Medicine 50:9, pages 1541-1547.
Crossref
Mange Ram Yadav, Vijay P. Pawar, Sejal M. Marvaniya, Parmeshwari K. Halen, Rajani Giridhar & Anil K. Mishra. (2008) Site specific chemical delivery of NSAIDs to inflamed joints: Synthesis, biological activity and γ-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites. Bioorganic & Medicinal Chemistry 16:21, pages 9443-9449.
Crossref
Elisabeth Miot-Noirault, Aurélien Vidal, Philippe Pastoureau, Jacques Bonafous, Agnès Chomel, Laurent Sarry, Laurent Audin, Jean-Claude Madelmont & Nicole Moins. (2007) Early detection and monitoring of cartilage alteration in the experimental meniscectomised guinea pig model of osteoarthritis by 99mTc-NTP 15-5 scintigraphy. European Journal of Nuclear Medicine and Molecular Imaging 34:8, pages 1280-1290.
Crossref
R P ChilcottC H Dalton, I Hill, C M Davison, K L Blohm, E D Clarkson & M G Hamilton. (2016) In vivo skin absorption and distribution of the nerve agent VX (O–ethyl–S–[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig. Human & Experimental Toxicology 24:7, pages 347-352.
Crossref
Maryse Rapp, Isabelle Giraud, Jean-Claude Maurizis & Jean-Claude Madelmont. (2003) Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma. Bioorganic & Medicinal Chemistry 11:23, pages 5007-5012.
Crossref
Peter Eyer. (2003) The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning. Toxicological Reviews 22:3, pages 165-190.
Crossref
Colette Nicolas, Michel Verny, Isabelle Giraud, Monique Ollier, Maryse Rapp, Jean-Claude Maurizis & Jean-Claude Madelmont. (1999) New Quaternary Ammonium Oxicam Derivatives Targeted toward Cartilage:  Synthesis, Pharmacokinetic Studies, and Antiinflammatory Potency. Journal of Medicinal Chemistry 42:25, pages 5235-5240.
Crossref
P. Cassiede, J. Amedee, L. Vuillemin, F. Rouais, R. Bareille, L. Bordenave, B. Basse-Cathalinat, M.F. Harmand & D. Ducassou. (1993) Radioimmunodetection of rat and rabbit cartilage using a monoclonal antibody specific to link proteins. Nuclear Medicine and Biology 20:7, pages 849-855.
Crossref
J.C. Maurizis, M. Ollier, C. Nicolas, J.C. Madelmont, H. Garrigue & A. Veyre. (1992) In vitro binding of oxime acetylcholinesterase reactivators to proteoglycans synthesized by cultured chondrocytes and fibroblasts. Biochemical Pharmacology 44:10, pages 1927-1933.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.