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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 5
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Original Article

Metabolism of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-pretreated rats: Stimulation and stereochemical effects by induction of cytochromes P450IIE1, P450IIB and P450IA

E. Elovaaraf Institute of Occupational Health, Topeliuksenkatu 41 A a, SF-00250, Helsinki, Finland
,
K. Engström Institute of Occupational Health, Topeliuksenkatu 41 A a, SF-00250, Helsinki, Finland
,
T. Nakajima Department of Hygiene, Shinshu University, School of Medicine, Matsumoto, 390, Japan
,
S. S. Parkii Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892, USA
,
H. V. Gelboin Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, Maryland, 20892, USA
&
H. Vainioj Institute of Occupational Health, Topeliuksenkatu 41 A a, SF-00250, Helsinki, Finland
Pages 651-661 | Received 15 Jul 1990, Accepted 08 Dec 1990, Published online: 27 Aug 2009

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Christopher R. Kirman, Richard A. Albertini & Michael L. Gargas. (2010) 1,3-Butadiene: III. Assessing carcinogenic modes of action. Critical Reviews in Toxicology 40:sup1, pages 74-92.
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Pavel Vodicka, Mikko Koskinen, Alessio Naccarati, Barbara Oesch-Bartlomowicz, Ludmila Vodickova, Kari Hemminki & Franz Oesch. (2006) Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity. Drug Metabolism Reviews 38:4, pages 805-853.
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M. E. Meek, R. Beauchamp, G. Long, D. Moir, L. Turner & M. Walker. (2002) CHLOROFORM: EXPOSURE ESTIMATION, HAZARD CHARACTERIZATION, AND EXPOSURE-RESPONSE ANALYSIS. Journal of Toxicology and Environmental Health, Part B 5:3, pages 283-334.
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Agneta Löf & Gunnar Johanson. (1998) Toxicokinetics of Organic Solvents: A Review of Modifying Factors. Critical Reviews in Toxicology 28:6, pages 571-650.
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D. L. MORGAN, J. F. MAHLER, R. E. WILSON, M. P. MOORMAN, H. C. PRICE$suffix/text()$suffix/text() & K. R. PATRICK. (1997) Effects of various pretreatments on the hepatotoxicity of inhaled styrene in the B6C3F1 mouse. Xenobiotica 27:4, pages 401-411.
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MelindaG. Gadberry, DennisB. DeNicola & GaryP. Carlson. (1996) PNEUMOTOXICITY AND HEPATOTOXICITY OF STYRENE AND STYRENE OXIDE. Journal of Toxicology and Environmental Health 48:3, pages 273-294.
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Susan Jenkins Sumner & Timothy R. Fennell. (1994) Review of the Metabolic Fate of Styrene. Critical Reviews in Toxicology 24:sup1, pages S11-S33.
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Articles from other publishers (13)

Eivor Elovaara, Jouni Mikkola, Helene Stockmann-Juvala, Leena Luukkanen, Helena Keski-Hynnilä, Risto Kostiainen, Markku Pasanen, Olavi Pelkonen & Harri Vainio. (2006) Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver. Archives of Toxicology 81:3, pages 169-182.
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Yukiko Minamiyama, Susumu Imaoka, Shigekazu Takemura, Shigeru Okada, Masayasu Inoue & Yoshihiko Funae. (2001) Escape from tolerance of organic nitrate by induction of cytochrome P450. Free Radical Biology and Medicine 31:11, pages 1498-1508.
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David A. Morgott. 2003. Patty's Toxicology. Patty's Toxicology.
Bjarte Mortensen, Peter O. Osvoll, Torill Woldbæk, Kolbjørn Zahlsen, Lngvar Eide & Odd G. Nilsen. (2009) In vitro Screening for Metabolic Interactions among Frequently Occurring Binary Mixtures of Volatile Organic Chemicals in Norwegian Occupational Atmosphere . Pharmacology & Toxicology 83:2, pages 49-56.
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Bjarte Mortensen & Odd G. Nilsen. (2009) Optimization and Application of the Head Space Liver S9 Equilibration Technique for Metabolic Studies of Organic Solvents. Pharmacology & Toxicology 82:3, pages 142-146.
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Bernard F. Gibbs & Catherine N. Mulligan. (1997) Styrene Toxicity: An Ecotoxicological Assessment. Ecotoxicology and Environmental Safety 38:3, pages 181-194.
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Susan C.J Sumner, Russell C Cattley, Bahman Asgharian, Derek B Janszen & Timothy R Fennell. (1997) Evaluation of the metabolism and hepatotoxicity of styrene in F344 rats, B6C3F1 mice, and CD-1 mice following single and repeated inhalation exposures1These data were presented in part at the 1995 Society of Toxicolgy meetings in Baltimore, MD.1. Chemico-Biological Interactions 106:1, pages 47-65.
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Kazuo Aoki, Wenyuan Zhao, Junichi Misumi, Takato Yasui & Masanobu Kudo. (2006) Changes in 2,5‐Hexanedione Concentration in the Sciatic Nerve, Serum and Urine of Rats Induced by Combined Administration of 2,5‐Hexanedione with Acetone or Methyl Ethyl Ketone. Journal of Occupational Health 38:1, pages 30-35.
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Teresa Coccini, Amalia Di Nucci, Marcello Tonini, Luciano Maestri, Lucio G. Costa, Maddalena Liuzzi & Luigi Manzo. (1996) Effects of ethanol administration on cerebral non-protein sulfhydryl content in rats exposed to styrene vapour. Toxicology 106:1-3, pages 115-122.
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A. M. Warhurst & C. A. Fewson. (2008) Microbial metabolism and biotransformations of styrene. Journal of Applied Bacteriology 77:6, pages 597-606.
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Johannes G. Filser, Ursula Schwegler, György A. Csanády, Helmut Greim, Paul E. Kreuzer & Winfried Kessler. (1993) Species-specific pharmacokinetics of styrene in rat and mouse. Archives of Toxicology 67:8, pages 517-530.
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Anne Smith-Kielland & Åse Ripel. (1993) Toluene metabolism in isolated rat hepatocytes: effects of in vivo pretreatment with acetone and phenobarbital. Archives of Toxicology 67:2, pages 107-112.
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Thomas Primiano, Sang Geon Kim & Raymond F. Novak. (1992) Differences between rats and rabbits in hepatic cytosolic glutathione S-transferase expression in response to nitrogen heterocycle and other inducers. Toxicology and Applied Pharmacology 113:1, pages 64-73.
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