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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 9
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Research Article

Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile—isolation of 12 new cyclosporine metabolites

U. Christians Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
,
S. Strohmeyer Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
,
R. Kownatzkij Zentrum Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
,
H.-M. Schiebel Institut für Organische Chemie, Technische Universität, Braunschweig, Germany
,
J. Bleck Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Hannover, Germany
,
J. Greipel Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
,
K. Kohlhaw Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
,
R. Schottmann Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
&
K.-F R. Sewing Institut für Allgemeine Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany
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Pages 1185-1198 | Received 28 Feb 1990, Accepted 16 Jan 1991, Published online: 22 Sep 2008

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Frank J. Belas & Ian A. Blair. (2001) MASS SPECTROMETRY IN PHARMACEUTICAL ANALYSIS*. Journal of Liposome Research 11:4, pages 309-342.
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U. Christians, S. Strohmeyer, R. Kownatzki, H.-M. Schiebel, J. Bleck, K. Kohlhaw, R. Schottmann & K.-F. R. Sewing. (1991) Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes. Xenobiotica 21:9, pages 1199-1210.
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Articles from other publishers (21)

Niels Bjerre Holm, Maria Deryabina, Carsten Boye Knudsen & Christian Janfelt. (2022) Tissue distribution and metabolic profiling of cyclosporine (CsA) in mouse and rat investigated by DESI and MALDI mass spectrometry imaging (MSI) of whole-body and single organ cryo-sections. Analytical and Bioanalytical Chemistry 414:24, pages 7167-7177.
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Xuerong Yang, Qi Li, Yuanyuan He, Yulian Zhu, Rou Yang, Xiaoshi Zhu, Xi Zheng, Wei Xiong & Yong Yang. (2022) Individualized medication based on pharmacogenomics and treatment progress in children with IgAV nephritis. Frontiers in Pharmacology 13.
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C. S. Brian Chia. (2021) A Review on the Metabolism of 25 Peptide Drugs. International Journal of Peptide Research and Therapeutics 27:2, pages 1397-1418.
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Malgorzata Szultka-Mlynska & Boguslaw Buszewski. (2019) Electrochemical oxidation of selected immunosuppressants and identification of their oxidation products by means of liquid chromatography and tandem mass spectrometry (EC-HPLC-MS/MS). Journal of Pharmaceutical and Biomedical Analysis 176, pages 112799.
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Maria Shipkova & Henar Valbuena. (2016) Liquid chromatography tandem mass spectrometry for therapeutic drug monitoring of immunosuppressive drugs: Achievements, lessons and open issues. TrAC Trends in Analytical Chemistry 84, pages 23-33.
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Andreas Becker, Oliver von Richter, Andreas Kovar, Holger Scheible, Jan J. van Lier & Andreas Johne. (2015) Metabolism and disposition of the αv-integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans. The Journal of Clinical Pharmacology 55:7, pages 815-824.
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Noël Knops, Elena Levtchenko, Bert van den Heuvel & Dirk Kuypers. (2013) From gut to kidney: Transporting and metabolizing calcineurin-inhibitors in solid organ transplantation. International Journal of Pharmaceutics 452:1-2, pages 14-35.
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Fatemeh Akhlaghi, Miroslav Dostalek, Pål Falck, Anisha E Mendonza, Rune Amundsen, Reginald Y Gohh & Anders Åsberg. (2012) The Concentration of Cyclosporine Metabolites Is Significantly Lower in Kidney Transplant Recipients With Diabetes Mellitus. Therapeutic Drug Monitoring 34:1, pages 38-45.
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W. Qiu, X. H. Jiang, C. X. Liu, Y. Ju & J. X. Jin. (2009) Effect of berberine on the pharmacokinetics of substrates of CYP3A and P‐gp. Phytotherapy Research 23:11, pages 1553-1558.
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Jhy-Wen Wu, Lie-Chwen Lin, Shih-Chieh Hung, Chi-Hung Lin, Chin-Wen Chi & Tung-Hu Tsai. (2008) Hepatobiliary Excretion of Silibinin in Normal and Liver Cirrhotic Rats. Drug Metabolism and Disposition 36:3, pages 589-596.
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K. Lehle, G.I. Kirchner, L. Rupprecht, M. Gruber, D.E. Birnbaum, F.-X. Schmid & J.G. Preuner. (2007) A Prospective Cross-Over Study Comparing the Pharmacokinetics of Cyclosporine A and Its Metabolites After Oral Versus Short-Time Intravenous Cyclosporine A Administration in Pre–Heart Transplant Patients. Transplantation Proceedings 39:10, pages 3323-3328.
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Yang Dai, Kazunori Iwanaga, Yvonne S. Lin, Mary F. Hebert, Connie L. Davis, Weili Huang, Evan D. Kharasch & Kenneth E. Thummel. (2004) In vitro metabolism of cyclosporine A by human kidney CYP3A5. Biochemical Pharmacology 68:9, pages 1889-1902.
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Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE. Drug Metabolism and Disposition 31:7, pages 815-832.
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Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, Scott R. Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective. The Journal of Clinical Pharmacology 43:5, pages 443-469.
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Steffen Bauer, Elke Störmer, Andreas Johne, Hagen Krüger, Klemens Budde, Hans-Hellmut Neumayer, Ivar Roots & Ingrid Mai. (2003) Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients. British Journal of Clinical Pharmacology 55:2, pages 203-211.
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Christian P Strassburg, Ayse Barut, Petra Obermayer-Straub, Qing Li, Nghia Nguyen, Robert H Tukey & Michael P Manns. (2001) Identification of cyclosporine A and tacrolimus glucuronidation in human liver and the gastrointestinal tract by a differentially expressed UDP-glucuronosyltransferase: UGT2B7. Journal of Hepatology 34:6, pages 865-872.
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Janice Simpson, Qingling Zhang, Panfilo Ozaeta & Hoda Aboleneen. (1998) A Specific Method for the Measurement of Cyclosporin A in Human Whole Blood by Liquid Chromatography-Tandem Mass Spectrometry. Therapeutic Drug Monitoring 20:3, pages 294-300.
Crossref
I. A. Blair. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 41 84 .
Klaus Eckart. (2005) Mass spectrometry of cyclic peptides. Mass Spectrometry Reviews 13:1, pages 23-55.
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I. ALI SHAH, P.H. WHITING, G. OMAR, A.D. ORMEROD & M.D. BURKE. (1993) The effects of retinoids and terbinafine on the human hepatic microsomal metabolism of cyclosporin. British Journal of Dermatology 129:4, pages 395-398.
Crossref
U. Christians & K.-F. Sewing. (1993) Cyclosporin metabolism in transplant patients. Pharmacology & Therapeutics 57:2-3, pages 291-345.
Crossref

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